Target Information
Target General Infomation | |||||
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Target ID |
T39013
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Former ID |
TTDR00409
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Target Name |
Vanilloid receptor
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Target Type |
Research
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Disease | Cough [ICD9: 786.2; ICD10: R05] | ||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Target Validation |
T39013
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Inhibitor | 1,3-dibenzyl urea | Drug Info | [529279] | ||
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide | Drug Info | [527001] | |||
6'-Iodononivamide | Drug Info | [531210] | |||
A-795614 | Drug Info | [529652] | |||
AMG-628 | Drug Info | [528915] | |||
ATC-120 | Drug Info | [530533] | |||
CAPSAZEPINE | Drug Info | [528825] | |||
IODORESINIFERATOXIN | Drug Info | [529209] | |||
JNJ-17203212 | Drug Info | [528825] | |||
MK-056 | Drug Info | [530533] | |||
N-(4-tert-butylphenyl)-4-(pyridin-2-yl)benzamide | Drug Info | [528334] | |||
Pyrrolidin-1-yl-thiourea | Drug Info | [527001] | |||
SC-0030 | Drug Info | [530533] | |||
References | |||||
Ref 527001 | Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. | ||||
Ref 528334 | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. Epub 2006 Jul 25.From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. | ||||
Ref 528825 | J Med Chem. 2007 May 31;50(11):2589-96. Epub 2007 May 10.The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. | ||||
Ref 528915 | J Med Chem. 2007 Jul 26;50(15):3528-39. Epub 2007 Jun 22.Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. | ||||
Ref 529209 | J Med Chem. 2008 Jan 10;51(1):57-67. Epub 2007 Dec 12.Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. | ||||
Ref 529279 | Eur J Med Chem. 2009 Jan;44(1):432-6. Epub 2007 Dec 28.Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. | ||||
Ref 529652 | Bioorg Med Chem. 2008 Sep 15;16(18):8516-25. Epub 2008 Aug 7.Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. |
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