Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 4-(2-{4-[(3-Benzo[1,3]dioxol-5-yl-propyl)-methyl-amino]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-8-dimethylaminomethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| PR --- mRNA of AR | 3-[(4-methoxyphenyl)phenylmethyl]indole | Drug Info |
| Erbeta --- ER | [6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(3-piperidin-1-yl-propyl)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | 4-acetyl-1-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-2-carboxamide | Drug Info |
| PR --- mRNA of AR | 8-Chloro-6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-isopropyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 4-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-2,15-dioxo-4-phenyl-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
| Erbeta --- ER | (2S,3R)-7-Hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(4-chloro-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-acetylamino-phenyl ester | Drug Info |
| Erbeta --- ER | 9a-benzyl-6-methyl-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one | Drug Info |
| MMP13 --- MMP9 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-2-propylpentanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzhydryl-amide | Drug Info |
| Erbeta --- ER | CHEMBL2135534 | Drug Info |
| MMP2 --- HER2 | (1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| S5AR --- SRD5A2 | 4-[2-(6-{[Bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethylbenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP2 --- MMP1 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phenoxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-formamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-bromo-phenyl)-amide | Drug Info |
| Erbeta --- mRNA of AR | SID4243681 | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-(4-phenyl-piperazin-1-yl)-hex-4-ynoic acid | Drug Info |
| S5AR --- SRD5A2 | 3-(1-Methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1Hpyrrole-2,5-dione | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-methoxy-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-chloro-phenyl)-amide | Drug Info |
| Ftase --- FPTase | 4-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester | Drug Info |
| MMP2 --- MMP13 | N-benzyl-1-(4-(1-cyclopropyl-4-(hydroxycarbamoyl)piperidin-4-ylsulfonyl)phenyl)-N-methylpiperidine-4-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-2-(tetrahydro-2H-pyran-4-yl)acetamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-ethoxy-phenyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2,5-dimethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbaldehyde | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(3,4-dimethylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-[1,4]diazepan-1-yl)-propoxy]-quinoline-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| PDGFR --- Src | 8-Methyl-2-(pyridin-4-ylamino)-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Ftase --- FPTase | 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| MMP2 --- MMP3 | 2-{4-[3'-(2-dimethylamino-ethoxy)-2-methyl-biphenyl-4-yl]-piperidine-1-sulfonyl}-N-hydroxy-2-methyl-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | [4-Anthracen-9-yl-1-(3H-imidazol-4-ylmethyl)-1H-pyrrol-3-yl]-p-tolyl-methanone | Drug Info |
| MMP2 --- MMP3 | (R)-2-[(S)-10-Amino-1-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-decylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID534102 | Drug Info |
| Ftase --- FPTase | (S)-2-[(2'-Methyl-5-pyrimidin-5-ylethynyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-2-(3-biphenyl-4-yl-propyl)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-succinamide | Drug Info |
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