Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-styrylpicolinamide | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzoic acid | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(2-ethyl-4-(3-(2-(pyridin-2-yl)-4-(trifluoromethyl)phenoxy)butoxy)phenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-benzofuran-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-Ethoxy-3-[4-methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | N2-(-4-aminocyclohexyl)-9-cyclopentyl-N8-(2-fluorophenyl)-9H-purine-2,8-diamine | Drug Info |
| Erbeta --- ER | 4-{6-[Bis-(2-ethoxy-ethyl)-amino]-4-phenyl-pyridin-2-yl}-2-methyl-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{[4-({butyl[2-chloro-4'-(trifluoromethyl)-3-biphenylyl]amino}sulfonyl)-2,3-dimethylphenyl]oxy}propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 4-((3aR,4S,9bS)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-4-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 5-(4-(3-(4-(4-fluoro-3-methylphenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | 4-amino-5-cyano-6-ethoxy-N-(4-(methylsulfonyl)benzyl)picolinamide | Drug Info |
| Erbeta --- ER | 4-{5-(4-hydroxy-phenyl)-4-methyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-furan-2-yl}-phenol | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-chlorophenyl)-2-bromothiazole-5-carboxamide | Drug Info |
| Erbeta --- ER | (4-(4-(4-chlorobenzoyl)piperazin-1-yl)phenyl)(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)methanone | Drug Info |
| JNK1 --- JNK3 | N-(2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-(4-hydroxy-2-methoxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-7-(1H-pyrazol-4-yl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(3-(piperidin-1-yl)propyl)phenyl)methanone | Drug Info |
| JNK3 --- MAPK | (S)-N*2*-Isopropyl-N*1*-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-3-phenyl-propane-1,2-diamine | Drug Info |
| Erbeta --- ER | (5S,6S)-6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalen-2-ol | Drug Info |
| MEP --- Cathepsin B | 4'-dimethylamino-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| Erbeta --- ER | 1,1,1-trifluoro-3,4-bis(4-hydroxyphenyl)butan-2-one | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(toluene-4-sulfonylamino)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-propoxy-benzyl}-butyric acid | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-3-methylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| MEP --- Cathepsin B | 2-((3,5-bis(trifluoromethyl)phenyl)(p-tolyl)methylene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | rac-1-chloro-9a-ethyl-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| MEP --- Cathepsin B | SID24801614 | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-hydroxyphenyl)-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-5-methyl-3-oxo-1-(2-oxopropyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-pyridin-2-ylmethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| Met --- VEGFR | 4-(4-(6-benzylpyridazin-3-yl)-2-fluorophenoxy)-6,7-dimethoxyquinoline | Drug Info |
| PR --- mRNA of AR | 1-Ethyl-6,8,8-trimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | Emodin | Drug Info |
| Met --- VEGFR | N-(4-(2-(1,3,4-thiadiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyanophenyl)-1-ethyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| Erbeta --- ER | methyl 4-(4-(2-fluorobenzyloxy)phenyl)-2-amino-7-hydroxy-4H-chromene-3-carboxylate | Drug Info |
| MMP1 --- MMP3 | 4-Amino-1-(4-butoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide | Drug Info |
| PR --- mRNA of AR | 9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 2-Chloro-4-((1R,2R,5R)-5-hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-1-(6-methoxy-1H-benzoimidazol-2-yl)-3-methyl-butyl]-succinamide | Drug Info |
| PR --- mRNA of AR | (+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol | Drug Info |
| Erbeta --- ER | 2-(3-Dimethylamino-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP1 --- MMP3 | 1,3-Bis-(4-methoxy-benzenesulfonyl)-imidazolidine-2-carboxylic acid hydroxyamide | Drug Info |
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