Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (S)-9a-ethyl-1-fluoro-6-(trifluoromethyl)-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| JNK1 --- JNK3 | 5-bromo-N-(3-chloro-2-(4-(furan-2-ylmethyl)piperazin-1-yl)phenyl)furan-2-carboxamide | Drug Info |
| VEGFR2 --- TEK | 7-[(3-bromothiophen-2-yl)carbonyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Erbeta --- ER | 4-(2-{4-[Methyl-(3-p-tolyl-propyl)-amino]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| JNK1 --- JNK3 | SID17506592 | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-morpholinophenyl)benzamide | Drug Info |
| Erbeta --- ER | 4-(3-fluoro-4-hydroxyphenyl)-1-naphthaldehyde oxime | Drug Info |
| JNK3 --- MAPK | 6-((S)-3-Benzyl-piperazin-1-yl)-3-naphthalen-1-yl-4-pyridin-4-yl-pyridazine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-methoxyphenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| MEP --- Cathepsin B | 3-[(R)-2-Cyano-2-((S)-2-phenylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| Erbeta --- ER | [4-Chloro-5-hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-yl]-acetonitrile | Drug Info |
| MEP --- Cathepsin B | (S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(1H-indazol-5-yl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| Erbeta --- ER | 4-(1-Butyl-1,7a-dihydro-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | Drug Info |
| MEP --- Cathepsin B | N-[2-(3-Morpholin-4-yl-ureido)-1-naphthalen-2-ylmethyl-2-oxo-ethyl]-2-[(E)-2-(naphthalene-2-sulfonyl)-vinylamino]-4-phenyl-butyramide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(3-chloro-4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Thiomorpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-[3-(2-trifluoromethyl-phenyl)-ureido]-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| VEGFR2 --- VEGFR1 | 3,4-Dichloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| Erbeta --- ER | (2-(4-butylphenyl)-6-hydroxybenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| Met --- VEGFR | 1-(3-fluoro-4-(2-(pyrimidin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| VEGFR2 --- VEGFR1 | 4-tert-Butyl-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| Erbeta --- ER | SID24396502 | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-4-(2-(isoxazol-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-methyl-2-pyrrolidin-1-yl-propoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-methyl-N3-phenylmalonamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| Erbeta --- ER | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-(4-p-tolyloxy-butyl)-succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2-methylphenyl)-2-(4-hydroxyphenyl)propanenitrile | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-[(S)-1-(1H-Benzoimidazol-2-yl)-3-methyl-butyl]-N*4*-hydroxy-2-isobutyl-succinamide | Drug Info |
| Erbeta --- ER | SID4248371 | Drug Info |
| MMP1 --- MMP3 | N-hydroxy-2-[[methyl(phenyl)phosphoryl](2-phenylethyl)amino]acetamide | Drug Info |
| Erbeta --- ER | rac-N-cyclopropyl-N-(2-(2,6-difluorophenyl)-2-hydroxypropyl)-4-hydroxybenzenesulfonamide | Drug Info |
| MMP1 --- MMP9 | 2-biphenyl-4-yl-N-tert-butyl-2-[(3R,6S)-3-mercaptomethyl-6-(4-nitro-benzyl)-2,5-dioxo-piperazin-1-yl]-acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-(4-(2-((3R,4S)-3,4-dimethylpyrrolidin-1-yl)ethoxy)phenyl)-3-(4-hydroxyphenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| MMP1 --- MMP9 | 1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-thiophen-2-yl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-chroman-6-ol | Drug Info |
| MMP13 --- MMP1 | (3S,4R)-4-[4-(2-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-inden-1-one | Drug Info |
| MMP13 --- MMP1 | 2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)pentyl(4-benzylbenzyl)phosphinic acid | Drug Info |
| Erbeta --- ER | 6-isobutyl-4,10-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| MMP13 --- MMP1 | 4-[4-(4-Fluoro-phenylsulfanyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 1-(4-hydroxyphenyl)-1H-indole-3-carbaldehyde oxime | Drug Info |
| MMP13 --- MMP1 | 4-[4-(Pyridin-3-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one | Drug Info |
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