Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP13 | 1-(benzo[d]oxazol-2-yl)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-Dimethylenastron | Drug Info |
| Ftase --- FPTase | 15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP13 | N1-ethyl-N4-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-1,4-dicarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 4-methyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP2 --- MMP13 | 1-(4-acetylpiperazin-1-ylsulfonyl)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-trifluoromethyl-biphenyl-4-ylamine | Drug Info |
| Ftase --- FPTase | N-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-benzamide | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-(4-morpholin-4-yl-phenyl)-pent-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| MMP2 --- MMP14 | 1-(benzylsulfonyl)-3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-dimethyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-biphenyl-3-carboxylic acid 13 (FTI-288) | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[1,1';4',1'']terphenyl-4-yl-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-8-fluoro-3-(3-hydroxy-propyl)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid | Drug Info |
| MMP2 --- MMP3 | 2-[4-(3'-ethoxy-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3'-Hydroxyphenyl)-3-benzyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxo-ethyl)-piperidin-4-yl]-ethanone | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-oxo-1-(phenethylamino)propan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3-(pyridin-2-ylmethyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
| Ftase --- FPTase | [2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylcarbamoyl)-ethyl]-phosphonic acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-(3-methoxy-3-oxopropylamino)-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-{(3R,3aR)-3-[3-(4-acetyl-piperazin-1-yl)-propyl]-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl}-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(4-trifluoromethoxy-phenyl)-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP9 | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-phenyl-pentanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(3-hydroxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-isopropyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(trifluoromethyl)biphenyl | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-thiophen-3-ylmethyl-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyramide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(diphenyl(4-(trifluoromethyl)phenyl)methylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | 4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-(N-(5-methylisoxazol-3-yl)sulfamoyl)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-2-chlorobenzamide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 11-(2',6'-Difluoro-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide] | Drug Info |
| Src --- VEGFR | CHEMBL216105 | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-((8-(dimethylamino)napththalen-4-yl)sulfonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR1 --- FGFR1 | 7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,5-b]pyridin-5(4H)-one | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| VEGFR2 --- AuroraA | 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionamide | Drug Info |
| VEGFR2 --- CD135 | N-{4-[3-amino-1-(2-hydroxyethyl)-1H-indazol-4-yl]phenyl}-N'-(3-methylphenyl)urea | Drug Info |
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