Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- EGFR3 | (2E)-N-{4-[(4-bromo-2-fluorophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide | Drug Info |
| Ftase --- FPTase | 1-[4-(4,8-Dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- FGFR1 | N*7*-(4-Diethylamino-butyl)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Ftase --- FPTase | N-Isopropyl-N-(1-methyl-1H-pyrazol-4-ylmethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine | Drug Info |
| VEGFR2 --- TEK | 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzonitrile | Drug Info |
| MMP-13 --- NEP | (S)-2-[(S)-3-[((R)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-(3-phenyl-isoxazol-5-ylmethyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionic acid | Drug Info |
| VEGFR2 --- TEK | 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-N,N-dimethyl-2-oxo-acetamide | Drug Info |
| NET --- SERT | 3-(3-Piperidin-4-yl-propyl)-1H-indole | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethoxy)benzamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-carbamoyl-butyric acid | Drug Info |
| NET --- SERT | 8-Methyl-2-(3-phenyl-[1,2,4]oxadiazol-5-yl)-3-p-tolyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| VEGFR2 --- TEK | 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-hexanoyl-piperazine-2-caboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | OSI-632 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-fluoro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-(methylsulfonyl)piperazin-1-yl)methyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 7-Cyclopentyl-6-morpholin-4-ylmethyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-4-yl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | SID124349821 | Drug Info |
| Ftase --- FPTase | N-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-2-mercapto-propionamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(2-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | [4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 3-piperidin-1-yl-propyl ester | Drug Info |
| Ftase --- FPTase | (2S)-2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| Cathepsin K --- MEP | N-{(S)-1-[2-(4-Benzyloxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-4-ethyl-benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-dimethylamino-benzenesulfonamide | Drug Info |
| H3 --- SERT | (2-(3,4-dichlorophenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | SID124349995 | Drug Info |
| PDE --- TNF alpha | 3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | [5-(4-Chloro-phenyl)-oxazol-2-yl]-(5-ethanesulfonyl-2-methoxy-phenyl)-amine | Drug Info |
| H3 --- SERT | (6S,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin-2-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino) quinazolin-7-yl)acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2,2-dimethylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | GW678313X | Drug Info |
| H3 --- SERT | (4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)(1-methyl-1H-pyrrol-2-yl)methanone | Drug Info |
| EGFR3 --- HER2 | 3-((5-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-ylamino)-1H-indazol-1-yl)methyl)benzonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-acetyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | (1H-indazol-3-yl)(2-(pyridin-4-ylmethylamino)phenyl)methanone | Drug Info |
| H3 --- SERT | N-methyl-N-(4-(3-((methylamino)methyl)-4-(4-(methylthio)phenoxy)phenyl)but-3-ynyl)cyclopropanamine | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-Chloro-4-fluorophenyl)amino]-6-quinazolinyl]-4-hydroxy-2-butynamide | Drug Info |
| PI3K gamma --- PI3K delta | 3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl]-phenol | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-bromophenyl)benzamide | Drug Info |
| HD6 --- HDAC2 | (S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid | Drug Info |
| EGFR3 --- HER2 | closantel | Drug Info |
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