Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PI3K gamma --- PI3K delta | 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-4-yl-thieno[3,2-d]pyrimidine | Drug Info |
| VEGFR2 --- VEGFR1 | 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidine | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-4-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-bromo-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-morpholinyl)-2-pentynamide | Drug Info |
| PI3K gamma --- PI3K delta | 4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-phenylamine | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-isopropylphenyl)benzamide | Drug Info |
| HD6 --- HDAC4 | N-benzyl-N-methyl-4-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | EGFR_ErbB_2_ErbB_4_Inhibitor | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-(2-hydroxy-6-methoxycarbonyl-benzoyl)-benzoic acid 2-(4-hydroxy-benzyl)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-phenyl)-(7-methyl-4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine | Drug Info |
| HDAC1 --- HD6 | (2E,4E,8E)-9-Benzo[1,3]dioxol-5-yl-nona-2,4,8-trienoic acid hydroxylamine | Drug Info |
| EGFR3 --- HER2 | (R)-7-(4-(1-(4-Fluorophenyl)ethylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-(2-hydroxy-6-methoxycarbonyl-benzoyl)-benzoic acid 3-(4-hydroxy-phenyl)-propyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-4-(2-(quinolin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(1-methyl-5-phenyl-1H-1,2,4-triazol-3-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | SID124350082 | Drug Info |
| PKCA --- NPKC delta | (2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(4,5-diphenylthiazol-2-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | 2-Cyano-3-[4-hydroxy-3-methoxy-5-(naphthalen-2-ylsulfanylmethyl)-phenyl]-acrylamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-2-(3-(4-fluorobenzyl)ureido)-N-(4-phenylthiazol-2-yl)-6-(sulfamoylamino)hexanamide | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(3-bromophenylamino)pyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| PPAR gamma --- PPAR delta | 5-(3-chloro-4-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HDAC1 --- HD6 | 3-(3-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- MCSF | (6,7-Dimethoxy-quinazolin-4-yl)-ethyl-phenyl-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((3-(4-tert-butylphenyl)-1-methyl-1H-pyrazole-5-carboxamido)methyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-3-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| Erbeta --- ER | 1-[4-(4-Cyclohexyl-piperazin-1-yl)-phenyl]-2-(3-hydroxy-phenyl)-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3-(4-benzoylphenoxy)propoxy)-3-chlorophenyl)-2-methoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 1-Methyl-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 1-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-[3-[2-[2-(4-Butylphenyl)-5-isopropyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid | Drug Info |
| HDAC1 --- HDAC2 | N-Hydroxy-4-(3-(3-methoxy-4-(pyridin-2-ylmethoxy)phenyl)-propanamido)benzamide | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(4-(3-methylbenzoyl)piperazin-1-yl)phenyl)methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(4-((4-chlorophenoxy)methyl)-2-(pent-2-ynyloxy)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-(biphenyl-4-yloxy)-2-oxo-octanoic acid ethylamide | Drug Info |
| Erbeta --- ER | [6-Ethynyl-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-((4-(4-Fluorophenoxy)benzamido)methyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC4 | (E)-3-(5-((E)-3-(2,5-Dichlorophenyl)-3-oxoprop-1-enyl)-furan-2-yl)-N-hydroxyacrylamide | Drug Info |
| Erbeta --- ER | 6-(4-Hydroxy-2-methylphenyl)-1-naphthol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-7-(3-(2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)chroman-2-carboxylic acid | Drug Info |
| HER2 --- CD221 | N-(4-(4-amino-1-(1'-(3-methoxypropyl)-1,4'-bipiperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 4,4'-(3,3,3-trifluoropropane-1,2-diyl)diphenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-{3-[(3,4-Bis-trifluoromethyl-benzoyl)-(2-cyclopropyl-3-[1,2,4]oxadiazol-3-yl-phenyl)-amino]-propyl}-phenoxy)-2-methyl-propionic acid | Drug Info |
| HER2 --- MMP-2 | (2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 4-(1-Phenethyl-1,7a-dihydro-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | Drug Info |
| PPAR gamma --- PPAR delta | (E)-2-(2-Methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)butyl)phenoxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(dimethylamino)ethyl)benzamide | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-8-hydroxy-4-(4-hydroxyphenyl)-1,3a,4,9b-tetrahydrocyclopenta[c]chromen-2(3H)-one | Drug Info |
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