Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-diethyl-5-isopropyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 3-(2-chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one | Drug Info |
| MMP13 --- MMP1 | [2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-[4-(2-ethoxy-benzyl)-benzyl]-phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-6-bromo-9a,11a-dimethyl-1-(3-methylbutanoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Erbeta --- ER | rac-6-bromo-9a-ethyl-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,7R)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 1-Benzyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP13 --- MMP1 | (S)-tert-butyl 4-(4-(3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholinosulfonyl)phenoxy)but-2-ynylcarbamate | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid biphenyl-4-ylamide | Drug Info |
| Erbeta --- ER | 12-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-7,12-dihydro-benzo[a]anthracene-3,11-diol | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (R)-3-{(2S,3S)-3-[2-(2,6-Diethyl-phenoxy)-acetylamino]-2-hydroxy-4-phenyl-butyryl}-thiazolidine-4-carboxylic acid tert-butylamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b] thio phene | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-(7-aminohept-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-2-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 2-(3-Ethyl-4-hydroxy-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-methoxy-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-yloxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 4-bromo-2-(4-hydroxyphenyl)quinolin-6-ol | Drug Info |
| MMP13 --- MMP8 | SID842343 | Drug Info |
| FGFR --- Src | 6-(2,6-Dibromo-phenyl)-N*2*-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-(m-tolyloxy)-2-(trifluoromethyl)-4H-chromen-4-one | Drug Info |
| MMP2 --- HER2 | (2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(3-hydroxyphenyl)-2-methyl-6-(piperidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Erbeta --- ER | 2-p-Tolyl-benzo[b]thiophen-6-ol | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-methyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- Mcl1 | SID85285613 | Drug Info |
| MMP2 --- MMP13 | 2-Biphenyl-4-yl-1,1-dioxo-1lambda*6*-isothiazolidine-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-methyl-6-morpholino-3-phenyl-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-2-naphthamide | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(1-morpholinopropan-2-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-(3-fluorobenzyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-1-(4-{2-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-3-mercapto-propan-1-one | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylbenzo[b]thiophene-5-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzo[d][1,3]dioxole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-carbamoyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Bromo-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(2-fluoro-5-trifluoromethyl-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-2-carboxylic acid (3-imidazol-1-yl-propyl)-amide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2-ethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | S-[cyclohexyl(diphenyl)methyl]-L-cysteine | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Bis-(4-nitro-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-(dimethylamino)-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-phenyl-pentyl]-phosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydroxy-prop-1-ynyl}-3''-ethoxy-biphenyl-3-carbonitrile | Drug Info |
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