Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 6-[(4-Chloro-phenyl)-imidazol-1-yl-methyl]-4-phenyl-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sulfonylamino)-propionic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(3-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| MMP3 --- MMP8 | [7-((S)-2-Amino-propionylamino)-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| Ftase --- FPTase | N-Furan-2-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP3 --- MMP8 | 2-[4-(Benzoylamino-methyl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 1-Methyl-1H-pyrazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-methyl-amide | Drug Info |
| MMP9 --- MMP3 | 2-(2-Mercapto-acetyl)-nonanoic acid ((S)-3-methyl-1-phenethylcarbamoyl-butyl)-amide | Drug Info |
| VEGFR2 --- CSrc | 2-((4-(4-methyl-1-piperazinyl)phenyl)-amino)-6-(2,4,6-trichlorophenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]-benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 2-(3-Fluoro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- AKT | (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl){6-[(3S,4R)-4-(4-fluorophenyl)tetrahydrofuran-3-ylamino]-pyrazin-2-yl}methanone | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-chloro-4-((4-ethylpiperazin-1-yl)methyl)benzamide | Drug Info |
| Ftase --- FPTase | H-SMGLPCVVM-OH | Drug Info |
| mTOR --- DNPK1 | 3-(imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| VEGFR2 --- CSrc | (6-Chloro-benzofuran-7-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | (+)4-(2-{4-[4-chloro-1-propyl-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate | Drug Info |
| mTOR --- PI3K gamma | Methyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| VEGFR2 --- CSrc | 6-(3-(methoxy)phenyl)-2-((4-(4-methyl-1-piperazinyl)phenyl)amino)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| mTOR --- PI3K gamma | (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- FGFR1 | CHEMBL1762529 | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3,5-Difluoro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide | Drug Info |
| VEGFR2 --- FGFR1 | 1-[2-Chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo [3,2-d]pyrimidin-4-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea | Drug Info |
| Ftase --- FPTase | N-sec-Butyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | 19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide | Drug Info |
| NET --- SERT | 2-Methyl-1-(8-methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-1-one | Drug Info |
| VEGFR2 --- TEK | 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Ethylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| NET --- SERT | 3-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarbonyloxy]propyl 4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxylate | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-methylthiophenyl)aminocarbonylamino)-phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-methoxy-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(7-chloro-4-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-{3-ethyl-19-methyl-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(4-methoxyphenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-3-(4-methylpiperazin-1-yl)prop-1-en-1-yl]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(3-(4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl)phenyl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-[1,2,4]triazol-1-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(3-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]urea | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-3-yl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpiperazin-1-yl)methyl)thiophen-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-azido-N-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethyl)-2,3,5,6-tetrafluorobenzamide | Drug Info |
| Ftase --- FPTase | 1-[2-(4-Cyano-phenyl)-2-hydroxy-2-(3-methyl-3H-imidazol-4-yl)-ethyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| CAII --- CAI | 4-Chloro-6-trifluoromethanesulfonylamino-benzene-1,3-disulfonic acid diamide | Drug Info |
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