Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HER2 --- MMP-2 | (2S,3S)-5-(2-(4-aminobutylamino)-2-oxoethyl)-N-hydroxy-2-(3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 7-(1,2-Dimethyl-propenyl)-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-(3-((4-(trifluoromethyl)benzamido)methyl)phenoxy)phenoxy)propanoic acid | Drug Info |
| JAK2 --- CD135 | (16E)-11-(2-(Pyrrolidin-1-yl)ethoxy)-14-(2,2,2-trifluoroethyl)-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]-heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene | Drug Info |
| Erbeta --- ER | 1-(4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-2-isopropoxypropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-3-chloro-2-fluorophenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 4-methoxy-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-3-yl-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-fluorobiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(4-(pyridin-4-yl)phenyl)acetamido)thiophene-2-carboxylate | Drug Info |
| Erbeta --- ER | 4,4'-(2-phenylethene-1,1-diyl)diphenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-methoxy-3-(3-methoxy-4-(3-(4-phenoxyphenoxy)propoxy)phenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 5-bromo-N-(3-chloro-2-(4-propylpiperazin-1-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | 3-(5-hydroxybenzo[d]oxazol-2-yl)benzene-1,2-diol | Drug Info |
| PPAR gamma --- PPAR delta | FARGLITAZAR | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(4-(1H-imidazol-1-yl)phenyl)acetamido)thiophene-2-carboxylate | Drug Info |
| Erbeta --- ER | SID14733222 | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylamino)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-(3-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 2-(5-chloro-2-(4-methoxyphenoxy)pyridin-4-ylamino)-N-methylbenzamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-(N-Isopropyl-N-methyl)benzamide)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| Erbeta --- ER | (R)-2-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)-2-phenyl-1H-indol-3-yl)-N-(4-(4-hydroxyphenyl)butan-2-yl)acetamide | Drug Info |
| JNK1 --- JNK3 | 4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid | Drug Info |
| PR --- mRNA of AR | rac-3-(3-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | broussonin A | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-dichlorophenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| PR --- mRNA of AR | 1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzene | Drug Info |
| Erbeta --- ER | 3-(5-bromo-6-hydroxynaphthalen-2-yl)benzo[d]isoxazol-6-ol | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[2,5-Dioxo-1-(3-phenyl-propyl)-piperidin-4-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester | Drug Info |
| PR --- mRNA of AR | 4-[1-(4-Fluorophenyl)-1H-indazol-5-yl]-N-(2-methylpropyl)-3-(trifluoromethyl)benzenesulfonamide | Drug Info |
| Erbeta --- ER | 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| MEP --- Cathepsin B | 2-(p-tolyl(3-(trifluoromethyl)phenyl)methylene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | (2-Cyclopentyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MEP --- Cathepsin B | 2-tert-Butyloxycarbonylamino-6,7-methylenedioxy-1-(4-methoxyphenyl)-2H-isoquinolin-3-one | Drug Info |
| PR --- mRNA of AR | 5-Bromo-4-methoxy-2-(2,6,6-trimethyl-4-methylene-cyclohex-2-enylmethyl)-phenol | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-ol | Drug Info |
| Erbeta --- ER | 2-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-1-phenyl-ethanone | Drug Info |
| Met --- VEGFR | (S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 3,8-dihydroxy-1,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide | Drug Info |
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