Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | 2-(2-(4-Methoxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-cycloheptyl ester | Drug Info |
| Src --- VEGFR | CHEMBL216105 | Drug Info |
| HDAC1 --- HD6 | 3-(4-(((2-(1H-indol-2-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (3-Chloro-4-fluoro-phenyl)-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-methylcarbamoyl-cyclopentyl ester | Drug Info |
| VEGFR1 --- FGFR1 | 7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,5-b]pyridin-5(4H)-one | Drug Info |
| HDAC1 --- HD6 | (R)-3-(3-(1-(1-ethylpiperidin-3-yl)-4,5-dimethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(bis(1-methylethyl)amino)-2-butynamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(2,3-dimethylphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- AuroraA | 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile | Drug Info |
| HDAC1 --- HD6 | 2-Phenoxyethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N4-(3-(6-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-4-yloxy)phenyl)pyrimidine-4,6-diamine | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-7-(2-{2-[(1E)-1,5-Dimethylhexen-1-yl]-5-methyloxazol-4-yl}ethoxy)-2-[(2E,4E)-hexadienoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| VEGFR2 --- CD135 | N-{4-[3-amino-1-(2-hydroxyethyl)-1H-indazol-4-yl]phenyl}-N'-(3-methylphenyl)urea | Drug Info |
| HDAC1 --- HD6 | (2E, 4E)-9-Benzo[1,3]dioxol-5-yl-nona-2,4-dienoic acid hydroxylamine | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid 2-(morpholine-1-yl)ethyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-difluorophenoxy)propanoic acid | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-4-(1H-indol-3-yl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-5-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| EGFR3 --- VEGFR1 | (1H-Indol-5-yl)-[2-(4-morpholin-4-ylmethyl-phenyl)-thieno[3,2-b]pyridin-7-yl]-amine | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,5-diisopropoxycinnamyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid amide | Drug Info |
| HDAC1 --- HDAC2 | 6-Phenyl-hexanoic acid hydroxyamide | Drug Info |
| Erbeta --- ER | SID56320859 | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(3-((5-chloro-1,3-dimethyl-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(4-((2-(dimethylamino)ethyl)(methyl)carbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| HDAC1 --- HDAC2 | diethyl(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzylamino)methylphosphonate | Drug Info |
| Erbeta --- ER | 10a,11-Dihydro-10-oxa-5-aza-benzo[b]fluorene-2,8-diol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)naphthalen-1-yl)-2-propoxypropanoic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| HDAC1 --- HDAC2 | 3-Methyl-benzofuran-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | CHEMBL187673 | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-benzyloxy-3-[(4-trifluoromethylbenzoylamino)methyl]benzyl}butyric acid | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-(2-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) | Drug Info |
| Erbeta --- ER | 2-(6-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(prop-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-bromophenyl)-4-methylbenzamide | Drug Info |
| HDAC1 --- HDAC4 | N1-(2-(hydroxycarbamoyl)phenyl)-N8-phenyloctanediamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-(4-hydroxyphenyl)-5-methylquinazoline-4(3H)-thione | Drug Info |
| Erbeta --- ER | 5,7-dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinethione | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2,3-dimethyl-4-(2-((tetrahydrofuran-2-yl)methoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)phenoxy)acetic acid | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-3-cyclopentylpropanamide | Drug Info |
| HER2 --- MMP-2 | (1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 1-(3-fluoro-4-hydroxyphenyl)-2-methyl-1H-indole-3-carbaldehyde oxime | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(5-(carboxymethoxy)-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)-5-chlorobenzoic acid | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-4-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| JAK2 --- STK1 | SID103904508 | Drug Info |
| Erbeta --- ER | 7-(2-bromovinyl)-2-(2-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
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