Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-(trifluoromethyl)-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-5-(3-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | SID103905195 | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)-5-hydroxybenzo[d]oxazole-7-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-ethoxy-3-(2-methyl-1-((5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethoxy)quinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | CHEMBL1194469 | Drug Info |
| PPAR gamma --- PPAR delta | 2-[4-Methoxy-3-(4-phenoxy-benzylcarbamoyl)-benzyl]-butyric acid | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-(1-Propyl-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(5-(3-(6-benzoylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| JNK1 --- JNK3 | 3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylazetidine-1-carboxamide | Drug Info |
| Erbeta --- ER | N-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine | Drug Info |
| JNK1 --- JNK3 | (S)-N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(1-hydroxypropan-2-ylamino)picolinamide | Drug Info |
| Erbeta --- ER | N(4-nitro-benzimidoyl chloride)Phenylamine | Drug Info |
| JNK1 --- JNK3 | N2-(-4-aminocyclohexyl)-9-cyclopentyl-N8-(2,6-difluorophenyl)-9H-purine-2,8-diamine | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(2-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)ethoxy)phenyl)-2-isopropoxypropanoic acid | Drug Info |
| Erbeta --- ER | 6-[2-(4-Hydroxy-phenyl)-1-methyl-ethyl]-pyridin-3-ol | Drug Info |
| JNK1 --- JNK3 | methyl 4-methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| PR --- mRNA of AR | (R)-3-ethyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-3,4-dihydro-2H-[1,4]oxazino[2,3-f]quinolin-8(7H)-one | Drug Info |
| Erbeta --- ER | 10-ethyl-3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| JNK3 --- MAPK | (S)-3-(4-Fluoro-phenyl)-N*1*-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-propane-1,2-diamine | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(3-fluorophenyl)-3-(3,4,5-trimethoxyphenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[4-(2-Dimethylamino-ethoxy)-phenyl]-3-(3-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | Allicin | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-(6,6-dimethyl-2-methylene-cyclohex-3-enylmethyl)-4-methoxy-phenol | Drug Info |
| Erbeta --- ER | 4-(4-hydroxyphenyl)benzo[b]thiophene-7-carbaldehyde oxime | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-3-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)-1-oxopropan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | 4-[1-(4-Fluorophenyl)-1H-indazol-5-yl]-N-propyl-3-(trifluoromethyl)benzenesulfonamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl) ethoxy]phenoxy}-2-phenylbenzo[b] thiophene | Drug Info |
| MEP --- Cathepsin B | [1-(1-Benzyl-3-tert-butylsulfanyl-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid pyridin-4-ylmethyl ester | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(3-chlorophenyl)-3-(4-fluorophenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-thioureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | 5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile | Drug Info |
| Erbeta --- ER | 3-hydroxy-8-methoxy-4,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | 5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| Erbeta --- ER | (2R,3S)-8-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| PR --- mRNA of AR | (+)-(S)-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | 1-[4-(4-Ethyl-3-methyl-piperazin-1-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[2-(1-Butyl-5,5-dimethyl-2-oxo-pyrrolidin-3-yl)-1-cyclohexylmethyl-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-N,N-dimethyl-benzamide | Drug Info |
| MMP1 --- MMP3 | (S)-2-Cyclohexyl-N*4*-hydroxy-N*1*-[(S)-3-methyl-1-(5-phenyl-1H-imidazol-2-yl)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(bis(4-fluorophenyl)methyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 4-(2-{4-[2-(4-Chloro-phenoxy)-ethylsulfanyl]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP1 --- MMP3 | 1-(4-Butoxy-benzenesulfonyl)-4-(1-methyl-1H-imidazole-4-sulfonylamino)-pyrrolidine-2-carboxylic acid hydroxyamide | Drug Info |
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