Target Validation Information
Target ID T99799
Target Name Cholinesterase
Target Type
Successful
Drug Potency against Target (-)-Phenserine Drug Info IC50 = 1560 nM
4-chlorophenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 10500 nM [529548]
3-methoxyphenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 710 nM [529548]
Isosorbide-2-(benzylcarbamate)-5-benzoate Drug Info IC50 = 4.3 nM [529716]
Cyclopentyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 3190 nM [529548]
P-tolyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 2850 nM [529548]
Isosorbide-2-benzylcarbamate-5-cyclopentanoate Drug Info IC50 = 6 nM [529716]
N-tert-Butyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 10600 nM [530749]
Isosorbide-2-(benzylcarbamate)-5-mononitrate Drug Info IC50 = 3.6 nM [529716]
(3-bromophenyl)(10H-phenothiazin-10-yl)methanone Drug Info Ki = 600 nM [528978]
N-n-octyl-7-methoxytacrine hydrochloride Drug Info IC50 = 120 nM [531150]
Isosorbide-2-(methylcarbamate)-5-mononitrate Drug Info IC50 = 5100 nM [529716]
N-n-pentyl-7-methoxytacrine hydrochloride Drug Info IC50 = 16000 nM [531150]
Isosorbide-2-(methylcarbamate)-5-benzoate Drug Info IC50 = 669 nM [529716]
3-(2-Diethylamino-propionamino)-rutaecarpine Drug Info IC50 = 2848 nM [530639]
Isosorbide-2-(butylcarbamate)-5-mononitrate Drug Info IC50 = 894 nM [529716]
N-Cyclopentyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 2990 nM [530749]
(4-bromophenyl)(10H-phenothiazin-10-yl)methanone Drug Info Ki = 1300 nM [528978]
Naphthalen-1-yl(10H-phenothiazin-10-yl)methanone Drug Info Ki = 88 nM [528978]
(10H-phenothiazin-10-yl)(m-tolyl)methanone Drug Info Ki = 1900 nM [528978]
3-(2-N-Pyrrolyl-propionamino)-rutaecarpine Drug Info IC50 = 844.5 nM [530639]
N-Cyclohexyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 2810 nM [530749]
Isosorbide-2-(cyclohexylcarbamate)-5-mononitrate Drug Info IC50 = 2500 nM [529716]
M-tolyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 1690 nM [529548]
2-biphenyl-4-yl-1-phenothiazin-10-yl-ethanone Drug Info Ki = 1700 nM [528978]
N-Phenyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 310 nM [530749]
N,N-Diisopropyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 180 nM [530749]
Tert-butyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 4300 nM [529548]
Isosorbide-2-benzylcarbamate-5-nicotinate Drug Info IC50 = 57 nM [529716]
Isosorbide-2-(butylcarbamate)-5-benzoate Drug Info IC50 = 72 nM [529716]
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one Drug Info IC50 = 150 nM [528456]
N-Neopentyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 2660 nM [530749]
9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide Drug Info IC50 = 4160 nM [530920]
N-o-Tolyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 710 nM [530749]
1-(10H-phenothiazin-10-yl)-3-phenylbutan-1-one Drug Info Ki = 1700 nM [528978]
N-Isopropyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 3410 nM [530749]
N,N-Dipropyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 430 nM [530749]
6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 2700 nM [528415]
N,N-Dimethyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 9200 nM [530749]
4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate Drug Info IC50 = 3520 nM [528979]
Isosorbide-2-benzylcarbamate-5-pentanoate Drug Info IC50 = 700 nM [529716]
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one Drug Info IC50 = 100 nM [528456]
1-(10H-phenothiazin-10-yl)-3-phenylpropan-1-one Drug Info Ki = 6200 nM [528978]
(10H-phenothiazin-10-yl)(p-tolyl)methanone Drug Info Ki = 2500 nM [528978]
1,2-di(10H-phenothiazin-10-yl)ethane-1,2-dione Drug Info Ki = 220 nM [528978]
(1'H-Phenothiazin-1'-yl)(piperidin-1-yl)methanone Drug Info Ki = 1560 nM [530749]
Isosorbide-2-benzylcarbamate-5-isonicotinate Drug Info IC50 = 88 nM [529716]
1-(10H-phenothiazin-10-yl)-2-phenylbutan-1-one Drug Info Ki = 400 nM [528978]
Phenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 570 nM [529548]
Isopropyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 18100 nM [529548]
4-[4-(benzyloxy)piperidino]butyl-3-chlorobenzoate Drug Info IC50 = 1350 nM [528979]
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one Drug Info IC50 = 1430 nM [528456]
(4-nitrophenyl)(10H-phenothiazin-10-yl)methanone Drug Info Ki = 820 nM [528978]
Butyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 13400 nM [529548]
1-(10H-phenothiazin-10-yl)-2-phenylethanone Drug Info Ki = 610 nM [528978]
Naphthalen-1-yl 10H-phenothiazine-10-carboxylate Drug Info Ki = 36 nM [529548]
Isosorbide-2-benzylcarbamate-5-acetate Drug Info IC50 = 4100 nM [529716]
3-chlorophenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 570 nM [529548]
1-(10H-phenothiazin-10-yl)-4-phenylbutan-1-one Drug Info Ki = 220 nM [528978]
N-Benzyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 4450 nM [530749]
4-[4-(benzyloxy)piperidino]butyl-4-nitrobenzoate Drug Info IC50 = 5230 nM [528979]
Naphthalen-2-yl(10H-phenothiazin-10-yl)methanone Drug Info Ki = 470 nM [528978]
Naphthalen-2-yl 10H-phenothiazine-10-carboxylate Drug Info Ki = 120 nM [529548]
1-(10H-phenothiazin-10-yl)-2-phenylpropan-1-one Drug Info Ki = 560 nM [528978]
1,4-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 231 nM [530920]
N-Cyclobutyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 10000 nM [530749]
4-[4-(benzyloxy)piperidino]butyl-4-fluorobenzoate Drug Info IC50 = 560 nM [528979]
1,3-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 531 nM [530920]
4-[4-(benzyloxy)piperidino]butyl-3-fluorobenzoate Drug Info IC50 = 1580 nM [528979]
9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide Drug Info IC50 = 2690 nM [530625]
N,N-Diethyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 1050 nM [530749]
4-[4-(benzyloxy)piperidino]butyl benzoate Drug Info IC50 = 1890 nM [528979]
N-n-heptyl-7-methoxytacrine hydrochloride Drug Info IC50 = 40 nM [531150]
N-(Adamant-1-yl)-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 350 nM [530749]
N-p-Tolyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 12100 nM [530749]
Isosorbide-di-(propylcarbamate) Drug Info IC50 = 10400 nM [530646]
(10H-phenothiazin-10-yl)(phenyl)methanone Drug Info Ki = 5800 nM [528978]
AS-1397 Drug Info IC50 = 3370 nM [528564]
9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide Drug Info IC50 = 4180 nM [530625]
5-methyl-cyclosal-d4TMP Drug Info IC50 = 4600 nM [528706]
7-Oxo-7H-dibenzo[de,g]quinoline Drug Info IC50 = 4010 nM [529985]
1-methyl-3-(phenylcarbamoyloxy)pyridinium bromide Drug Info IC50 = 550 nM
Isosorbide-2-(propylcarbamate)-5-mononitrate Drug Info IC50 = 639 nM [529716]
2-Methyl-beta-carboline-2-ium iodide Drug Info IC50 = 540 nM [530824]
N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP Drug Info IC50 = 102 nM [529368]
(24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol Drug Info Ki = 4600 nM [527846]
24-ethylcholest-6-ene-3,5-diol Drug Info Ki = 4200 nM [527846]
3-sal-cyclosal-d4TMP Drug Info IC50 = 2300 nM [528706]
3-isopr-sal-cyclosal-d4TMP Drug Info IC50 = 4700 nM [528706]
3-phenyl-cyclosal-d4TMP Drug Info IC50 = 350 nM [528706]
NSC-23180 Drug Info Ki = 1670 nM [529103]
3-(2-N-Pyrrolyl-acetamino)-rutaecarpine Drug Info IC50 = 696.1 nM [530639]
24-ethyl-cholest-7-ene-3,5,6-triol Drug Info Ki = 2500 nM [527846]
Isosorbide-di-(butylcarbamate) Drug Info IC50 = 1220 nM [530646]
Haloxysterol D Drug Info Ki = 2200 nM [527846]
2-Propyl-beta-carboline-2-ium iodide Drug Info IC50 = 2305 nM [530824]
1,11-bis(pyridinium)-undecane dibromide Drug Info IC50 = 7000 nM [530696]
N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP Drug Info IC50 = 192 nM [529368]
N,N'-(1',3'-propylene)-bis-(-)-nor-MEP Drug Info IC50 = 132 nM [529368]
MEPTAZINOL Drug Info IC50 = 15000 nM [529368]
N,N'-(1',4'-butylene)-bis-(-)-nor-MEP Drug Info IC50 = 104 nM [529368]
Isosorbide-2-(ethylcarbamate)-5-mononitrate Drug Info IC50 = 3900 nM [529716]
N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP Drug Info IC50 = 10 nM [529368]
N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP Drug Info IC50 = 100 nM [529368]
4-methoxyphenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 2260 nM [529548]
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine Drug Info IC50 = 7200 nM [528402]
6-chlorotacrine hydrochloride Drug Info IC50 = 916 nM [530301]
9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide Drug Info IC50 = 2220 nM [530625]
CAPROCTAMINE Drug Info IC50 = 11600 nM [529775]
(+/-)-huprineY hydrochloride Drug Info IC50 = 236 nM [528570]
Isosorbide-2-benzylcarbamate-5-triflate Drug Info IC50 = 359 nM [529716]
Bis-cyclosal-d4TMP Drug Info IC50 = 14000 nM [528706]
Isosorbide-2-benzylcarbamate-5-(o-toluate) Drug Info IC50 = 1.2 nM [530632]
6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1600 nM [528415]
2-methoxyphenyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 340 nM [529548]
O-tolyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 390 nM [529548]
Methyl 10H-phenothiazine-10-carboxylate Drug Info Ki = 10200 nM [529548]
HEPTYPHYSOSTIGMINE Drug Info IC50 = 5 nM [528106]
TOLSERINE Drug Info IC50 = 1950 nM [528106]
Iso-OMPA Drug Info IC50 = 733 nM [529716]
3-(2-N-Piperidyl-propionamino)-rutaecarpine Drug Info IC50 = 2112 nM [530639]
VAGANINE D Drug Info IC50 = 10000 nM [526090]
Isosorbide-2-benzyl carbamate Drug Info IC50 = 3700 nM [530632]
3-(dimethylamino)phenyl phenylcarbamate Drug Info IC50 = 18000 nM
Isosorbide-2-benzylcarbamate-5-cyclopropanoate Drug Info IC50 = 334 nM [529716]
1,2-NAPHTHOQUINONE Drug Info Ki = 2290 nM [529103]
1,10-bis(pyridinium)-decane dibromide Drug Info IC50 = 5000 nM [530696]
1,9-bis(pyridinium)-nonane dibromide Drug Info IC50 = 6000 nM [530696]
3,4,5,6-Tetrachloro-[1,2]benzoquinone Drug Info Ki = 3200 nM [527510]
N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine Drug Info IC50 = 13800 nM [530923]
Haloxysterol C Drug Info Ki = 18000 nM [527846]
LAWSARITOL Drug Info Ki = 3700 nM [527846]
XANTHOSTIGMINE Drug Info IC50 = 48 nM [534716]
(-)-Tolserine Drug Info IC50 = 1950 nM
HALOXYSTEROL B Drug Info Ki = 2500 nM [527846]
N,N'-(1',6-hexylene)-bis-(-)-nor-MEP Drug Info IC50 = 119 nM [529368]
N,N'-(1',2'-ethylene)-bis-(-)-nor-MEP Drug Info IC50 = 125 nM [529368]
N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP Drug Info IC50 = 74 nM [529368]
N,N'-(1',8'-octylene)-bis-(-)-nor-MEP Drug Info IC50 = 63 nM [529368]
9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide Drug Info IC50 = 2050 nM [530920]
Morpholino(1'H-phenothiazin-1'-yl)methanone Drug Info Ki = 7100 nM [530749]
N-n-nonyl-7-methoxytacrine hydrochloride Drug Info IC50 = 360 nM [531150]
N,N'-(1',10'-decylene)-bis-(-)-nor-MEP Drug Info IC50 = 17 nM [529368]
3-(2-Diethylamino-acetamino)-rutaecarpine Drug Info IC50 = 17620 nM [530639]
9-Ethyl-2-methyl-beta-carboline-2-ium iodide Drug Info IC50 = 2019 nM [530824]
Isosorbide-2-benzylcarbamate-5-propionate Drug Info IC50 = 980 nM [529716]
6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole Drug Info IC50 = 17400 nM [528415]
3-[3-(benzylmethylamino)propoxy]xanthen-9-one Drug Info IC50 = 8330 nM [528456]
6-methoxy-2-methyl-9H-beta-carbolin-2-ium Drug Info IC50 = 17500 nM [528415]
6-hydroxy-2-methyl-9H-beta-carbolin-2-ium Drug Info IC50 = 8700 nM [528415]
9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide Drug Info IC50 = 5440 nM [530920]
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one Drug Info IC50 = 100 nM [528456]
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one Drug Info IC50 = 80 nM [528456]
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one Drug Info IC50 = 2490 nM [528456]
3-[4-(benzylmethylamino)butoxy]xanthen-9-one Drug Info IC50 = 2650 nM [528456]
9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide Drug Info Ki = 1020 nM [530625]
N-benzyl-2-thiomorpholinopyrimidin-4-amine Drug Info IC50 = 2300 nM [530923]
9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide Drug Info IC50 = 3000 nM [530625]
1,2-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 1110 nM [530920]
Isosorbide-di-(benzylcarbamate) Drug Info IC50 = 400 nM [530646]
N-Methyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 18300 nM [530749]
(-)-Phenethylcymserine Drug Info IC50 = 6 nM
LIPOCRINE Drug Info IC50 = 11 nM [530437]
MEMOQUIN Drug Info IC50 = 1440 nM [530437]
Anthracen-10-yl(10H-phenothiazin-10-yl)methanone Drug Info Ki = 3.5 nM [528978]
(10H-phenothiazin-10-yl)(o-tolyl)methanone Drug Info Ki = 3100 nM [528978]
1,2-indanedione Drug Info Ki = 2630 nM [529103]
ACENAPHTHOQUINONE Drug Info Ki = 2970 nM [529103]
5,6-dinitroacenaphthoquinone Drug Info Ki = 3100 nM [529103]
Phenanthrene-9,10-dione Drug Info Ki = 190 nM [529103]
9-O-[3-(Phenylamino)propyl]-berberine bromide Drug Info IC50 = 1760 nM [530920]
Huprine X Drug Info Ki = 120 nM [528216]
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione Drug Info Ki = 12600 nM [528749]
1,2-bis(2,3-fluorophenyl)ethane-1,2-dione Drug Info Ki = 1270 nM [528766]
BENZOQUINONE Drug Info Ki = 2050 nM [527510]
CHLORANIL Drug Info Ki = 268 nM [527510]
Cyclosal-d4TMP Drug Info IC50 = 770 nM [528706]
Bis-7-tacrine Drug Info IC50 = 10.5 nM [530923]
NOSTOCARBOLINE Drug Info IC50 = 13200 nM [527942]
4-ISOPROPYLPHENSERINE Drug Info IC50 = 240 nM [530692]
(RS)-tacrine(10)-hupyridone Drug Info IC50 = 81.5 nM [529473]
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one Drug Info IC50 = 120 nM [528456]
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one Drug Info IC50 = 800 nM [528456]
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1200 nM [528415]
HALOXYSTEROL A Drug Info Ki = 4500 nM [527846]
CHF-2819 Drug Info IC50 = 1700 nM [527437]
N-n-hexyl-7-methoxytacrine hydrochloride Drug Info IC50 = 1000 nM [531150]
DEMETHYLDEBROMOFLUSTRAMINE B Drug Info IC50 = 260 nM [529633]
(-)-DEBROMOFLUSTRAMINE B Drug Info IC50 = 1370 nM [529633]
References
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 530639Eur J Med Chem. 2010 Apr;45(4):1415-23. Epub 2010 Jan 4.Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 530639Eur J Med Chem. 2010 Apr;45(4):1415-23. Epub 2010 Jan 4.Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 529548J Med Chem. 2008 Jul 24;51(14):4200-12. Epub 2008 Jun 21.Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Ref 528456Bioorg Med Chem. 2007 Jan 1;15(1):575-85. Epub 2006 Sep 27.Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 530920Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. Epub 2010 Apr 27.Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 528978Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 528415Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. Epub 2006 Sep 1.6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.
Ref 530749Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. Epub 2010 Feb 4.Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.
Ref 528979Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Ref 529716J Med Chem. 2008 Oct 23;51(20):6400-9. Epub 2008 Sep 26.Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
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