Target Validation Information
Target ID T64567
Target Name Carbonic anhydrase IX
Target Type
Successful
Drug Potency against Target UMBELLIFERONE Drug Info Ki = 482 nM [1]
1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info Ki = 540 nM [2]
MAFENIDE Drug Info Ki = 103 nM [3]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide Drug Info Ki = 8800 nM [4]
PHENOL Drug Info Ki = 8800 nM [5]
4-(2-Amino-ethyl)-benzenesulfonamide Drug Info Ki = 33 nM [6]
Hexane-1,6-diamine Drug Info Ki = 410 nM [7]
COUMATE Drug Info Ki = 34 nM [8]
P-Coumaric Acid Drug Info Ki = 5330 nM [9]
ELLAGIC ACID Drug Info Ki = 9370 nM [9]
2-oxo-2H-thiochromene-3-carboxylic acid Drug Info Ki = 6200 nM [10]
3-Amino-benzenesulfonamide Drug Info Ki = 238 nM [11]
7-butoxy-2H-chromen-2-one Drug Info Ki = 4900 nM [10]
N1-(2-aminoethyl)ethane-1,2-diamine Drug Info Ki = 10600 nM [7]
4-(Carbamolymethylthio)pyridine-3-sulfonamide Drug Info Ki = 11.8 nM [12]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 5700 nM [10]
6-(hydroxymethyl)-2H-chromen-2-one Drug Info Ki = 8400 nM [10]
2-(benzyloxyamino)-N-hydroxyhexanamide Drug Info Ki = 7600 nM [4]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 181 nM [13]
Prop-2-ynyl 4-sulfamoylbenzoate Drug Info Ki = 104 nM [14]
N-propynyl amidebenzenesulphonide Drug Info Ki = 113 nM [14]
CATECHIN Drug Info Ki = 5030 nM [5]
8-acetyl-7-propoxy-2H-chromen-2-one Drug Info Ki = 56.7 nM [1]
Decyl sulfamate Drug Info Ki = 23.1 nM [15]
1,4-phenylene disulfamate Drug Info Ki = 61.6 nM [16]
Aminobenzolamide derivative Drug Info Ki = 4.6 nM [17]
8-Propionyl-7-propoxy-2H-chromen-2-one Drug Info Ki = 50.2 nM [1]
Syringic Acid Drug Info Ki = 8200 nM [9]
2-propylamido-5-sulfonamidoindane Drug Info Ki = 2320 nM [18]
4-(Allylamino)-3-pyridinesulfonamide Drug Info Ki = 12 nM [12]
2-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 30 nM [18]
N-(4-Sulfamoyl-phenyl)-propionamide Drug Info Ki = 106 nM [19]
2-ethylamido-5-sulfonamidoindane Drug Info Ki = 2015 nM [18]
4,4'-thiodipyridine-3-sulfonamide Drug Info Ki = 47.3 nM [12]
4-(Methylhydrazino)-3-pyridinesulfonamide Drug Info Ki = 15.8 nM [12]
3-(3-Phenyl-ureido)-benzenesulfonamide Drug Info Ki = 14 nM [19]
4-(Cyanomethylthio)pyridine-3-sulfonamide Drug Info Ki = 11.7 nM [12]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide Drug Info Ki = 9500 nM [20]
2-butylamido-5-sulfonamidoindane Drug Info Ki = 3.4 nM [18]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide Drug Info Ki = 175 nM [21]
2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide Drug Info Ki = 7100 nM [4]
4-Methylthiopyridine-3-sulfonamide Drug Info Ki = 47 nM [12]
PHENYLDIFLUOROMETHANESULFONAMIDE Drug Info Ki = 8500 nM [22]
Sulfamic acid 3-sulfamoyloxy-phenyl ester Drug Info Ki = 100 nM [23]
NSC-654077 Drug Info Ki = 653 nM [24]
2-valproylamido-5-sulfonamidoindane Drug Info Ki = 282 nM [18]
2-acetamido-5-sulfonamidoindane Drug Info Ki = 290 nM [18]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide Drug Info Ki = 7.2 nM [12]
1-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 3.5 nM [18]
2-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 33 nM [18]
3-Chloro-4-hydrazino-benzenesulfonamide Drug Info Ki = 149 nM [21]
4-(2-Propynylthio)pyridine-3-sulfonamide Drug Info Ki = 6.3 nM [12]
N-(4-Sulfamoyl-phenyl)-isobutyramide Drug Info Ki = 139 nM [19]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester Drug Info Ki = 525 nM [23]
4-methylphenyl-difluoromethanesulfonamide Drug Info Ki = 250 nM [22]
Sulfamic acid 7-sulfamoyloxy-heptyl ester Drug Info Ki = 10.1 nM [23]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide Drug Info Ki = 6900 nM [4]
Sulfamic acid 4-sulfamoyloxy-butyl ester Drug Info Ki = 24 nM [23]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide Drug Info Ki = 7.5 nM [12]
ACETYLSULFANILAMIDE Drug Info Ki = 135 nM [19]
5-Amino-[1,3,4]thiadiazole-2-thiol Drug Info Ki = 9300 nM [20]
4-Hydrazino-3-pyridinesulfonamide Drug Info Ki = 4.9 nM [12]
2-(benzyloxyamino)-N-hydroxyacetamide Drug Info Ki = 6700 nM [4]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 290 nM [16]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide Drug Info Ki = 7.1 nM [25]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide Drug Info Ki = 65 nM [26]
Pentanoic acid (4-sulfamoyl-phenyl)-amide Drug Info Ki = 79 nM [19]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide Drug Info Ki = 18 nM
7-methoxy-8-propionyl-2H-chromen-2-one Drug Info Ki = 37.8 nM [1]
Quinoline-8-sulfonamide Drug Info Ki = 32 nM [16]
4-ethynyl benzene sulfonamide Drug Info Ki = 8.1 nM [27]
N-hydroxysulfamide Drug Info Ki = 865 nM [28]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide Drug Info Ki = 9.1 nM [24]
ETHOXYCOUMARIN Drug Info Ki = 9600 nM [10]
4-(2-Hydroxy-ethyl)-benzenesulfonamide Drug Info Ki = 22 nM [29]
PARABEN Drug Info Ki = 3730 nM [9]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 31 nM [29]
4-Amino-3-fluoro-benzenesulfonamide Drug Info Ki = 245 nM [29]
Decane-1,10-diyl disulfamate Drug Info Ki = 7 nM [15]
Carzenide Drug Info Ki = 26 nM [29]
SPERMINE Drug Info Ki = 13300 nM [7]
2,4-Disulfamyltrifluoromethylaniline Drug Info Ki = 24 nM [29]
6-Hydroxy-benzothiazole-2-sulfonic acid amide Drug Info Ki = 14 nM [29]
PHENYLSULFAMATE Drug Info Ki = 63 nM [22]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate Drug Info Ki = 9400 nM [10]
HYDROSULFIDE Drug Info Ki = 7000 nM [30]
FERULIC ACID Drug Info Ki = 9870 nM [9]
Sulfamic acid 6-sulfamoyloxy-hexyl ester Drug Info Ki = 13.2 nM [23]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester Drug Info Ki = 32.1 nM [23]
Octyl sulfamate Drug Info Ki = 3.5 nM [15]
Octane-1,8-diyl disulfamate Drug Info Ki = 4 nM [15]
HERNIARIN Drug Info Ki = 9800 nM [10]
6-acetyl-7-propoxy-2H-chromen-2-one Drug Info Ki = 7580 nM [1]
7-phenethoxy-2H-chromen-2-one Drug Info Ki = 5800 nM [10]
2-Sulfamoyl-benzoic acid methyl ester Drug Info Ki = 680 nM [21]
4-azidobenzenesulfonamide Drug Info Ki = 105 nM [31]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info Ki = 6.1 nM [32]
Curcumin Drug Info Ki = 4050 nM [5]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 5400 nM [10]
N1-(naphthalen-1-yl)ethane-1,2-diamine Drug Info Ki = 510 nM [7]
(4-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 7730 nM [22]
4-Amino-3-iodo-benzenesulfonamide Drug Info Ki = 285 nM [29]
2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 6500 nM [10]
2-hydrazinylbenzenesulfonamide Drug Info Ki = 176 nM [29]
4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info Ki = 39 nM [29]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide Drug Info Ki = 16 nM [29]
5-amino-1,3,4-thiadiazole-2-sulfonamide Drug Info Ki = 41 nM [33]
PHENYLMETHANESULFONAMIDE Drug Info Ki = 9300 nM [22]
(2-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 9280 nM [22]
COUMARIN Drug Info Ki = 9100 nM [10]
4-nitrophenyl-difluoromethanesulfonamide Drug Info Ki = 2420 nM [22]
MMI270 Drug Info Ki = 7800 nM [4]
Azide Drug Info Ki = 5000 nM [30]
GALLICACID Drug Info Ki = 6990 nM [9]
7-hydroxy-8-propionyl-2H-chromen-2-one Drug Info Ki = 58.2 nM [1]
4-Amino-3-chloro-benzenesulfonamide Drug Info Ki = 264 nM [29]
N-(pentafluorophenyl)sulfamide Drug Info Ki = 19 nM [34]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 48 nM [10]
4-Amino-3-bromo-benzenesulfonamide Drug Info Ki = 269 nM [29]
2-nonylamido-5-sulfonamidoindane Drug Info Ki = 3.7 nM [18]
1-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 108 nM [18]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide Drug Info Ki = 7.9 nM [12]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid Drug Info Ki = 4100 nM [10]
1-valproylamido-5-sulfonamidoindane Drug Info Ki = 37.5 nM [18]
2-Amino-benzenesulfonamide Drug Info Ki = 33 nM [29]
1-acetamido-5-sulfonamidoindane Drug Info Ki = 193 nM [18]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide Drug Info Ki = 18 nM [19]
6-acetyl-7-methoxy-2H-chromen-2-one Drug Info Ki = 7800 nM [1]
7-propoxy-2H-chromen-2-one Drug Info Ki = 8100 nM [10]
8-acetyl-7-ethoxy-2H-chromen-2-one Drug Info Ki = 70.8 nM [1]
P-TOLUENESULFONAMIDE Drug Info Ki = 460 nM [29]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info Ki = 6.4 nM [32]
8-acetyl-7-(benzyloxy)-2H-chromen-2-one Drug Info Ki = 72.3 nM [1]
8-acetyl-7-methoxy-2H-chromen-2-one Drug Info Ki = 78.3 nM [1]
8-Acetyl-7-hydroxy-2H-chromen-2-one Drug Info Ki = 73 nM [1]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 112 nM [19]
6-Acetyl-7-ethoxy-2H-chromen-2-one Drug Info Ki = 7400 nM [1]
N-(4-Sulfamoyl-phenyl)-butyramide Drug Info Ki = 83 nM [19]
8-acetyl-7-butoxy-2H-chromen-2-one Drug Info Ki = 61.2 nM [1]
3-Fluoro-4-hydrazino-benzenesulfonamide Drug Info Ki = 136 nM [21]
6-Acetyl-7-hydroxy-2H-chromen-2-one Drug Info Ki = 8030 nM [1]
7-ethoxy-8-propionyl-2H-chromen-2-one Drug Info Ki = 46.7 nM [1]
7-hydroxy-6-propionyl-2H-chromen-2-one Drug Info Ki = 8015 nM [1]
4-Hydrazino-benzenesulfonamide Drug Info Ki = 294 nM [29]
2-Hydrazinocarbonyl-benzenesulfonamide Drug Info Ki = 547 nM [21]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 313 nM [12]
SACCHARIN Drug Info Ki = 103 nM [35]
3-bromophenyl-difluoromethanesulfonamide Drug Info Ki = 1495 nM [22]
4-Benzenesulfonylamino-benzenesulfonamide Drug Info Ki = 52 nM [19]
3-((4-aminophenyl)diazenyl)benzenesulfonamide Drug Info Ki = 5.9 nM [32]
(4-sulfamoylphenylethylthioureido)fluorescein Drug Info Ki = 24 nM [24]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester Drug Info Ki = 61.6 nM [23]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide Drug Info Ki = 9200 nM [4]
4-Benzythiopyridine-3-sulfonamide Drug Info Ki = 30.4 nM [12]
4-(Quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 9.1 nM [12]
4-(hydroxymethyl)benzenesulfonamide Drug Info Ki = 21 nM [29]
N-(4-cyanophenyl)sulfamide Drug Info Ki = 45 nM [34]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide Drug Info Ki = 6 nM [32]
BENZOLAMIDE Drug Info Ki = 47 nM [29]
SULFAMATE Drug Info Ki = 9200 nM [36]
SULFAMIDE Drug Info Ki = 9600 nM [36]
BICARBONATE Drug Info Ki = 8600 nM [36]
INDISULAM Drug Info Ki = 24 nM [25]
7-(benzyloxy)-2H-chromen-2-one Drug Info Ki = 4300 nM [10]
Pentane-1,5-diamine Drug Info Ki = 380 nM [7]
6-(aminomethyl)-2H-chromen-2-one Drug Info Ki = 8400 nM [10]
4-Ethoxy-3-pyridinesulfonamide Drug Info Ki = 300 nM [12]
Sodium phenylaminomethanesulfonate Drug Info Ki = 5100 nM [32]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide Drug Info Ki = 7.8 nM [12]
4-Methanesulfonylamino-benzenesulfonamide Drug Info Ki = 113 nM [19]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide Drug Info Ki = 136 nM [19]
N-(4-Sulfamoyl-phenyl)-benzamide Drug Info Ki = 73 nM [19]
Sodium N-methylphenylaminomethanesulfonate Drug Info Ki = 5850 nM [32]
4-(4'-N-Methylphenyl)diazenylbenzenesulfonamide Drug Info Ki = 4.9 nM [32]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide Drug Info Ki = 7.8 nM [25]
4-Methoxy-3-pyridinesulfonamide Drug Info Ki = 5.7 nM [12]
References
REF 1Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
REF 2Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
REF 3J Med Chem. 2010 Apr 8;53(7):2913-26.Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.
REF 4Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates.
REF 5Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
REF 6J Med Chem. 2005 Jul 28;48(15):4834-41.Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
REF 7J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
REF 8Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. Epub 2008 Jul 5.Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
REF 9Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
REF 10J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
REF 11Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
REF 12Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.
REF 13Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72.Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
REF 14J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".
REF 15J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
REF 16Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.
REF 17Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
REF 18J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX.
REF 19Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
REF 20Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.
REF 21J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties.
REF 22Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
REF 23Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
REF 24J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs.
REF 25Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.
REF 26J Med Chem. 2006 Sep 7;49(18):5544-51.Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
REF 27J Med Chem. 2008 Mar 27;51(6):1945-53. Epub 2008 Feb 29.Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.
REF 28Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
REF 29J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
REF 30Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
REF 31Bioorg Med Chem Lett. 2009 Apr 15;19(8):2273-6. Epub 2009 Feb 26.Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
REF 32Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II.
REF 33Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. Epub 2010 Jun 17.Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamideresides in a less utilized binding pocket than most hydrophobic inhibitors.
REF 34Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
REF 35Bioorg Med Chem Lett. 2008 Jan 15;18(2):836-41. Epub 2007 Nov 13.Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potentinhibitors of the tumor-associated isoforms IX and XII.
REF 36Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.