Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V5HV
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| Former ID |
DIB021042
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| Drug Name |
TFMPP
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| Synonyms |
1-[3-(Trifluoromethyl)phenyl]piperazine; 15532-75-9; 1-(3-(Trifluoromethyl)phenyl)piperazine; 1-(3-Trifluoromethylphenyl)piperazine; N-(3-trifluoromethylphenyl)piperazine; 3-trifluoromethylphenylpiperazine; Legal E [Street Name]; Piperazine, 1-[3-(trifluoromethyl)phenyl]-; UNII-25R3ONU51C; 1-(m-trifluoromethylphenyl)piperazine; 1-(3-Trifluoromethyl-phenyl)-piperazine; EINECS 239-574-4; N-(alpha,alpha,alpha-trifluoro-m-tolyl)piperazine; NSC 128882; N-(alpha,alpha,alpha-Trifluoro-3-tolyl)piperazine; 3-trifluoromethylphenylpiperazine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H13F3N2
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| Canonical SMILES |
C1CN(CCN1)C2=CC=CC(=C2)C(F)(F)F
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| InChI |
1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
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| InChIKey |
KKIMDKMETPPURN-UHFFFAOYSA-N
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| CAS Number |
CAS 15532-75-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
420065, 3136502, 5432187, 8152670, 10509163, 11335998, 11361237, 11363121, 11365683, 11368245, 11371899, 11374618, 11376407, 11462209, 11485242, 11489389, 11490785, 11492904, 11494041, 14773789, 16960152, 24724637, 26756537, 29223395, 44055626, 47440307, 47515359, 47589039, 47662328, 48110493, 49748625, 49831162, 50067841, 50111390, 57322229, 57654712, 58033924, 78282691, 81120314, 85209744, 85261774, 85770679, 85788306, 85789252, 96021246, 103169357, 103858708, 103920681, 104305990, 104668757
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| ChEBI ID |
CHEBI:83536
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 115). | |||
| REF 2 | Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. | |||
| REF 3 | Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. | |||
| REF 4 | Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. | |||
| REF 5 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. | |||
| REF 6 | Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. | |||
| REF 7 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
| REF 8 | Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. | |||
| REF 9 | Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse. 2000 Feb;35(2):144-50. | |||
| REF 10 | Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993 Mar;43(3):313-9. | |||
| REF 11 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. | |||
| REF 12 | Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4. | |||
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