miRNA General Information
miRNA Mature ID hsa-miR-497-5p
miRNA Stemloop AC MI0003138
miRNA Stemloop ID hsa-mir-497
Sequence cagcagcacacugugguuugu
TTD Target(s) Regulated by This miRNA Serine/threonine-protein kinase mTOR (mTOR) Successful Target Target Info [1]
Cyclin-dependent kinase 4 (CDK4) Successful Target Target Info [2]
Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [3]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [4]
Estrogen-related receptor-alpha (ESRRA) Successful Target Target Info [5]
ERK activator kinase 1 (MEK1) Clinical trial Target Target Info [6]
Checkpoint kinase-1 (CHK1) Clinical trial Target Target Info [7]
Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Target Info [8]
Ribosomal protein S6 kinase beta-1 (S6K1) Clinical trial Target Target Info [1]
Wee1-like protein kinase (WEE1) Clinical trial Target Target Info [9]
Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Target Info [10]
Proto-oncogene c-RAF (c-RAF) Clinical trial Target Target Info [11]
Calcium-activated potassium channel KCa3.1 (KCNN4) Clinical trial Target Target Info [12]
Facilitates chromatin transcription complex (FACT) Clinical trial Target Target Info [9]
M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Target Info [2]
G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Target Info [9]
Cyclin D (CCND3) Literature-reported Target Target Info [2]
Eukaryotic initiation factor 4E (EIF4E) Literature-reported Target Target Info [13]
Hepatoma-derived growth factor (HDGF) Literature-reported Target Target Info [9]
Wnt-7a protein (WNT7A) Literature-reported Target Target Info [10]
Angiomotin (AMOT) Literature-reported Target Target Info [14]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [11]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [15]
Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Target Info [16]
Protein(s) Regulated by This miRNA Anillin Regulated Protein [17]
E3 ubiquitin-protein ligase SMURF1 Regulated Protein [18]
F-box/WD repeat-containing protein 1A Regulated Protein [2]
Heat shock 70 kDa protein 4L Regulated Protein [17]
Metastasis-associated in colon cancer protein 1 Regulated Protein [20]
Pre-B-cell leukemia transcription factor 3 Regulated Protein [21]
Twist-related protein 1 Regulated Protein [22]
REF 1 MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1. Oncotarget. 2015 Sep 22;6(28):26457-71.
REF 2 The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One. 2013;8(3):e60155.
REF 3 MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene. 2013 Apr 11;32(15):1910-20.
REF 4 miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Med Oncol. 2012 Mar;29(1):384-91.
REF 5 MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeti... Tumour Biol. 2016 Oct;37(10):13205-13214.
REF 6 MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway. FEBS Lett. 2012 Nov 30;586(23):4165-72.
REF 7 Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma. Med Oncol. 2014 Mar;31(3):844.
REF 8 Tumor-suppressive microRNA-497 targets IKK to regulate NF-B signaling pathway in human prostate cancer cells. Am J Cancer Res. 2015 Apr 15;5(5):1795-804.
REF 9 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 10 The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster. PLoS One. 2014 Feb 10;9(2):e84311.
REF 11 Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res. 2011 Apr 1;17(7):1722-30.
REF 12 miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma. Oncotarget. 2016 Sep 6;7(36):58148-58161.
REF 13 The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. Biochem Biophys Res Commun. 2014 Jun 27;449(2):235-40.
REF 14 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 15 The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Sci Rep. 2017 Jan 18;7:40958.
REF 16 Experimental evidences for hsa-miR-497-5p as a negative regulator of SMAD3 gene expression. Gene. 2016 Jul 25;586(2):216-21.
REF 17 The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.Oncotarget. 2015 Nov 3;6(34):35893-907.
REF 18 MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.Biochem Biophys Res Commun. 2014 Jul 11;449(4):432-7.
REF 19 The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One. 2013;8(3):e60155.
REF 20 Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer.Oncotarget. 2017 Jan 17;8(3):4125-4135.
REF 21 MicroRNA-497 suppresses cell proliferation and induces apoptosis through targeting PBX3 in human multiple myeloma. Am J Cancer Res. 2016 Dec 1;6(12):2880-2889.
REF 22 Twist promotes angiogenesis in pancreatic cancer by targeting miR-497/VEGFA axis.Oncotarget. 2016 May 3;7(18):25801-14.

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