Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46185 | Target Info | |||
| Target Name | Muscarinic acetylcholine receptor M2 (CHRM2) | ||||
| Synonyms |
M2 receptor; CHRM2
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| Target Type | Successful Target | ||||
| Gene Name | CHRM2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 83 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Carbachol
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|
Approved | Compound Info | ||
| Synonyms |
Carbach; Carbacholin; Carbacholine; Carbacholinum; Carbacholum; Carbacol; Carbacolina; Carbacolo; Carbamiotin; Carbamoylcholine; Carbastat; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Coletyl; Doryl; Jestryl; Karbachol; Lentin; Lentine; Miostat; Moryl; Rilentol; Vasoperif; CARBACHOL CHLORIDE; Carbachol hydrochloride; Carbacholine chloride; Carbacholini chloridum; Carbacholinium chloratum; Carbacholum chloratum; Carbacolo [DCIT]; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamoylcholine chloride; Carbamylcholine chloride; Choline carbamate chloride; Choline chloride carbamate; Choline chlorine carbamate; Isopto Carbachol; Karbachol [Czech]; Karbamoylcholin chlorid; Karbamoylcholin chlorid [Czech]; Lentine [French]; Mistura C; C 4382; TL 457; C-1770; Carbacholum [INN-Latin]; Carbacol [INN-Spanish]; Carbamic acid, ester with choline chloride; Carbamoylcholine-hydrochloride; Carbastat (TN); Carboptic (TN); Choline chloride, carbamate; Doryl (VAN); Doryl (pharmaceutical); Gamma-Carbamoyl choline chloride; Isopto Carbachol (TN); Miostat (TN); Carbachol [INN:BAN:JAN]; Choline, chloride carbamate(ester); Choline, chloride, carbamate; P. V. Carbachol; Carbachol (JAN/USP/INN); Choline, chloride, carbamate, hydrochloride; Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride; Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1); (2-Carbamoyloxy-ethyl)-trimethyl-ammonium; (2-Carbamoyloxy-ethyl)-trimethyl-ammonium(Carbachol); (2-Carbamoyloxyethyl)trimethylammonium chloride; (2-Hydroxyethyl)trimethyl ammonium chloride carbamate; (2-Hydroxyethyl)trimethylammonium chloride carbamate; (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride; 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride; 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride; 2-carbamoyloxyethyl(trimethyl)azanium chloride
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| Activity |
EC50 = 61000 nM
|
[1] | |||
| Compound Name |
Pilocarpine
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Approved | Compound Info | ||
| Synonyms |
Adsorbocarpine; Almocarpine; Epicar; Isopilocarpine; Isoptocarpine; Miocarpine; Ocusert; Pilagan; Pilocarpin; Pilocarpol; Pilokarpin; Pilokarpol; Pilostat; Salagen; Spersacarpine; Syncarpine; Amistura P; Isopto carpine; Minims Pilocarpine; Ocusert pilo; Pilocarpine HCl; Pilocarpine chloride; Pilocarpine nitrate; Ocusert P 20;Beta-Pilocarpine hydrochloride; Diocarpine (TN); Isopto Carpine (TN); Mi-Pilo; Miocarpine (TN); Ocu-Carpine; Ocusert Pilo-40; Ocusert pilo-20; Pilocarpine (TN); Pilopine HS (TN); Piloptic-1; Piloptic-2; Piloptic-3; Piloptic-4; Piloptic-6; Salagen (TN); Scheinpharm (TN); Timpilo (TN); Ocusert Pilo-20 (TN); Ocusert pilo-20 (TN); P.V. Carpine Liquifilm; Pilocarpine (JAN/USP); Pilocarpine [USAN:BAN:JAN]; Piloptic-1/2; Pilocarpine Mononitrate, (3S-cis)-Isomer; Pilocarpine, Monohydrochloride, (3S-cis)-Isomer; Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone; (+)-Pilocarpine; (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one; (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone; 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one; 3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone; 3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one; 3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone; 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
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| Activity |
EC50 = 63000 nM
|
[2] | |||
| Compound Name |
AZD7687
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Phase 1 | Compound Info | ||
| Synonyms |
AZD7687; 1166827-44-6; CHEMBL2178944; CHEMBL2178953; AZD-7687; AZD 7687; UNII-6QTJ9P2NYT; 6QTJ9P2NYT; SCHEMBL2252415; SCHEMBL5532381; SCHEMBL2252417; GTPL7827; SCHEMBL2255196; DTXSID60655297; YXFNPRHZMOGREC-SHTZXODSSA-N; 3466AH; ZINC43206395; BDBM50399684; BDBM50399710; AZD 7687;AZD-7687; ZINC101581684; AKOS030526281; CS-1026; NCGC00378858-01; HY-15497; KB-144428; W-5990; {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid; {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid
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| Activity |
IC50 = 80500 nM
|
[3] | |||
| Compound Name |
PD-151832
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Discontinued in Phase 1/2 | Compound Info | ||
| Synonyms |
PD-142505 (racemate); (-)-(R)-(Z)-3-[3-(3-Methoxyphenyl)-2-propynyloxyimino]-1-azabicyclo[2.2.1]heptane
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL489576; BDBM50263936
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476990; BDBM50263413; 2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL518747; BDBM50263371
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490597; BDBM50263889; 1-(1''-Benzyl-[1,4'']bipiperidinyl-4-yl)-5-chloro-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490598; BDBM50263890; 4-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521914; BDBM50263893
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477821; SCHEMBL5476466; BDBM50263372; 1-[1''-(2-Chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478034; BDBM50263411; 1-[1''-(2-Nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2-Methoxyphenyl)-N,N,N-trimethylmethanaminium iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095774; DTXSID70503457; BDBM50246747; NSC167787; NSC-167787
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL523657; BDBM50263837; 5-Chloro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL491818; BDBM50263937
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL491208; BDBM50263886; 2-[4-(5-Chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-[1,4'']bipiperidinyl-1''-ylmethyl]-benzonitrile
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490797; BDBM50263892; 6-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[(1-Methylpiperidin-3-yl)oxymethyl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070061; BDBM50246703
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| Activity |
EC50 = 50000 nM
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[5] | |||
| Compound Name |
3-(3-Methoxyphenyl)prop-2-ynyl-trimethylazanium;formate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092769; BDBM50246714
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| Activity |
Ki = 50000 nM
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[5] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL515489; BDBM50263410; 5-Chloro-1-[1''-(2-chloro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
8-Hydroxy-2-(dimethylamino)-1,2,3,4-tetrahydronaphthalene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146953; SCHEMBL8891132; BDBM50246626; 7-(dimethylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
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| Activity |
Ki ~ 50000 nM
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[5] | |||
| Compound Name |
6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL522451; BDBM50263891; 5-Fluoro-1-[1''-(2-methyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
Tbpb
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Investigative | Compound Info | ||
| Synonyms |
1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; CHEMBL522460; GTPL3258; SCHEMBL5473311; BCP13406; TBPB, >=98% (HPLC); BDBM50263887; ZINC40423557; AKOS026750197; CS-3517; NCGC00390669-01; DA-41854; HY-14562; QC-11734; FT-0746315; Y6339; A14205; BRD-K86989957-001-01-7; Q27088942; 1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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| Activity |
EC50 ~ 50000 nM
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[6] | |||
| Compound Name |
Spiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL290715; SCHEMBL9666430; CTK2F0555; DTXSID60577945; BDBM50005849; spiro[4-azabicyclo[2.2.2]octane-2,4''-[1,3]dioxolane]; spiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane]
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| Activity |
Ki = 50000 nM
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[7] | |||
| Compound Name |
3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478662; SCHEMBL5486679; BDBM50263370; 1-(1''-(2-(trifluoromethyl)benzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-[1''-(2-Trifluoromethyl-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL514689; BDBM50263412; 5-Chloro-1-[1''-(2-nitro-benzyl)-[1,4'']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-2-(1-methyl-3-indolyl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294649; N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-2-(1-methylindol-3-yl)-2-oxoacetamide; NCGC00024919-01; Tocris-0988; Biomol-NT_000140; BPBio1_000200; SCHEMBL7379450; ZINC1534160; BDBM50213344; NCGC00024919-02; (R)-RS-56812; Q7277679; BRD-K20714604-001-01-5; BRD-K20714604-003-01-1; (r)-N-(quinuclidin-3-yl)-2-(1-methyl-1 h-indol-3-yl)-2-oxo-acetamide
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| Activity |
Ki = 50118.72 nM
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[8] | |||
| Compound Name |
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-1-methyl-alpha-oxo-3-indoleacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL298612; SCHEMBL7386983; BDBM50213343; N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2-(1-methylindol-3-yl)-2-oxoacetamide
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| Activity |
Ki = 50118.72 nM
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[8] | |||
| Compound Name |
3-(2-Ethyl-2H-1,2,3-triazole-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131095; SCHEMBL12043367; BDBM50038224; L012648; 5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine
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| Activity |
EC50 ~ 51000 nM
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[9] | |||
| Compound Name |
(2R,3S,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092736; BDBM50475676
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| Activity |
Ki = 51286.14 nM
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[10] | |||
| Compound Name |
3-(3-Furyl)quinuclidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL144737; 1-Azabicyclo[2.2.2]octan-3-ol,3-(3-furanyl)-; SCHEMBL7398071; BDBM50036187; 3-(furan-3-yl)-1-azabicyclo[2.2.2]octan-3-ol; 3-Furan-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol; (+/-) 3-(Fur-3-yl)-3-hydroxy-1-azabicyclo[2.2.2]octane
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| Activity |
Ki ~ 53000 nM
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[11] | |||
| Compound Name |
1-Aza-bicyclo[2.2.1]heptan-3-one O-(4-methoxy-but-2-ynyl)-oxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168991; BDBM50280563
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| Activity |
IC50 = 59300 nM
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[12] | |||
| Compound Name |
Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594803
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| Activity |
Ki = 60255.96 nM
|
[13] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL404557
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| Activity |
Ki = 61659.5 nM
|
[14] | |||
| Compound Name |
(S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)-propionic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL115078; N-Myristoyl-Gly-L-Ser-OBzl; BDBM50083651
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| Activity |
Ki = 64565.42 nM
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[15] | |||
| Compound Name |
1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(2-methoxy-phenyl)-prop-2-ynyl]-oxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86150; BDBM50065211
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| Activity |
IC50 = 69300 nM
|
[1] | |||
| Compound Name |
Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595022
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| Activity |
Ki = 72443.6 nM
|
[13] | |||
| Compound Name |
(2R)-2-(Furan-2-yl)pyrrolidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461088; Pyrrolidine, 2-(2-furanyl)-, (2R)-; ZINC3732225; BDBM50412429; AKOS006329719
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| Activity |
Ki = 77624.71 nM
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[16] | |||
| Compound Name |
(2S,3S,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092735; BDBM50475687
Click to Show/Hide
|
||||
| Activity |
Ki = 77624.71 nM
|
[10] | |||
| Compound Name |
(2S,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553241; BDBM50478154
Click to Show/Hide
|
||||
| Activity |
Ki = 77624.71 nM
|
[17] | |||
| Compound Name |
[(2R,6R)-6-Benzhydryl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042551
Click to Show/Hide
|
||||
| Activity |
Ki = 79432.82 nM
|
[18] | |||
| Compound Name |
(2S,3R,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093082; BDBM50475679
Click to Show/Hide
|
||||
| Activity |
Ki = 81283.05 nM
|
[10] | |||
| Compound Name |
(2R,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541424; BDBM50478149
Click to Show/Hide
|
||||
| Activity |
Ki = 81283.05 nM
|
[17] | |||
| Compound Name |
1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(4-methoxy-phenyl)-prop-2-ynyl]-oxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84919; BDBM50065220; L008746
Click to Show/Hide
|
||||
| Activity |
IC50 = 84400 nM
|
[1] | |||
| Compound Name |
(2S,3S,5S)-2-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,3-oxathiolane 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092737; BDBM50475688
Click to Show/Hide
|
||||
| Activity |
Ki = 87096.36 nM
|
[10] | |||
| Compound Name |
[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593864
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[13] | |||
| Compound Name |
(2R,3S,5R)-2-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,3-oxathiolane 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3351105; BDBM50475677
Click to Show/Hide
|
||||
| Activity |
Ki = 89125.09 nM
|
[10] | |||
| Compound Name |
2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391353; BDBM50435313
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[19] | |||
| Compound Name |
N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168223; BDBM50474495
Click to Show/Hide
|
||||
| Activity |
Ki = 93325.43 nM
|
[20] | |||
| Compound Name |
[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594802
Click to Show/Hide
|
||||
| Activity |
Ki = 95499.26 nM
|
[13] | |||
| Compound Name |
N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391367; SCHEMBL975152; BDBM50435331; AKOS032990511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441756
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312376; BDBM50426266
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
3-[(1-Methylpyrrolidin-3-yl)methoxymethyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091032; BDBM50246702
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309717
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441760
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391366; SCHEMBL974224; BDBM50435332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441750
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441757
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441752
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312346; BDBM50426242
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441751
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500313; BDBM50256181
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3309715
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Esaprazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Cyclohexyl-2-piperazin-1-yl-acetamide; Exaprazole; N-cyclohexyl-2-piperazin-1-ylacetamide; N-cyclohexyl-2-(piperazin-1-yl)acetamide; N-Cyclohexyl-1-piperazineacetamide; UNII-38QSU0IB5L; 1-Piperazineacetamide, N-cyclohexyl-; Hexaprazol; 38QSU0IB5L; 1-Piperazineacetamide,N-cyclohexyl-; MFCD00865680; hexaprazole; NCGC00160434-01; DSSTox_CID_26147; DSSTox_RID_81379; DSSTox_GSID_46147; Esaprazole [INN]; Esaprazola; Esaprazolum; Esaprazolum [INN-Latin]; Esaprazola [INN-Spanish]; BRN 0785765; Prazol; N-cyclohexyl-2-piperazin-1-ylacetamide dihydrochloride; 5-23-02-00264 (Beilstein Handbook Reference); MLS004754470; SCHEMBL931007; CHEMBL1983100; DTXSID0046147; CTK5C0914; ALBB-013043; Tox21_111808; 7294AE; BDBM50435343; ZINC19737386; AKOS000209735; Tox21_111808_1; MCULE-8782683340; NE28840; N-cyclohexyl-2-(1-piperazinyl)acetamide; NCGC00160434-02; AS-44244; SMR002529465; n-(cyclohexyl-2-piperazin-1-yl)-acetamide; FT-0678584; EN300-68725; AE-641/00334033; AE-641/30178021; SR-01000883686; SR-01000883686-1; 1-piperazineacetamide, N-cyclohexyl-, dihydrochloride; BRD-K92426617-001-01-4; Q27256807; Z234896745
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311547; BDBM50426233
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
N-Isopropyl-1-piperazineacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
n-isopropyl-2-(piperazin-1-yl)acetamide; N-isopropyl-2-piperazin-1-ylacetamide; 2-piperazin-1-yl-N-propan-2-ylacetamide; 2-(piperazin-1-yl)-N-(propan-2-yl)acetamide; CHEMBL2391356; 1-Piperazineacetamide, N-(1-methylethyl)-; N-(methylethyl)-2-piperazinylacetamide; EINECS 254-676-9; NSC379438; SCHEMBL255190; CTK4I2048; KS-00003TBM; DTXSID10192925; N-isopropyl-2-piperazinoacetamide; 2-piperazinyl-N-isopropylacetamide; N-isopropyl-1-piperazine acetamide; piperazinoacetic acid isopropylamide; ALBB-006203; 2503AE; BDBM50435342; MFCD00005969; SBB027314; STK501255; ZINC19942920; AKOS000264275; MCULE-4117297184; NSC-379438; VP70271; N-Isopropyl-1-piperazineacetamide, 95%; TS-02582; 1-Piperazineacetamide,N-(1-methylethyl)-; N-Isopropyl-2-(1-piperazinyl)acetamide #; DB-049493; BB 0259628; FT-0639584; ST45024241; EN300-18601; W-6183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441754; SCHEMBL21541688; (5S)-5-[(dimethylamino)methyl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441758
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279105; BDBM50062158; 1,4-Dimethyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[24] | |||
| Compound Name |
2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391352; BDBM50435314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391382; SCHEMBL974621; BDBM50435316
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391374; BDBM50435324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312347; BDBM50426241
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220553; BDBM50194316; (5R,2''S)-5[1''-methylpyrrolidin-2''-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359597
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441753
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441759
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391368; SCHEMBL976125; BDBM50435329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391357; SCHEMBL1024404; BDBM50435341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441755
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441761
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(2S)-2-(Furan-2-yl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451335; Pyrrolidine, 2-(2-furanyl)-, (2S)-; SCHEMBL6181015; ZINC2582574; BDBM50412428
Click to Show/Hide
|
||||
| Activity |
Ki = 107151.93 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 21 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228144; BDBM50003014
Click to Show/Hide
|
||||
| Activity |
EC50 = 1.29E+12 nM
|
[25] | |||
| Compound Name |
1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403029
Click to Show/Hide
|
||||
| Activity |
Ki = 2.19E+12 nM
|
[26] | |||
| Compound Name |
4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255692
Click to Show/Hide
|
||||
| Activity |
Ki = 4.68E+12 nM
|
[26] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)piperazin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404866
Click to Show/Hide
|
||||
| Activity |
Ki = 5.62E+12 nM
|
[26] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[2-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]ethyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257586
Click to Show/Hide
|
||||
| Activity |
Ki = 2.09E+13 nM
|
[26] | |||
| Compound Name |
Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390842
Click to Show/Hide
|
||||
| Activity |
EC50 = 2.69E+13 nM
|
[25] | |||
| Compound Name |
4-(4-Methylpiperazin-1-yl)-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258161
Click to Show/Hide
|
||||
| Activity |
Ki = 2.82E+13 nM
|
[26] | |||
| Compound Name |
4-(1-Methyl-4-phenylpiperazin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257547
Click to Show/Hide
|
||||
| Activity |
Ki = 3.89E+13 nM
|
[26] | |||
| Compound Name |
4-(4,4-Dimethylpiperazin-4-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436850
Click to Show/Hide
|
||||
| Activity |
Ki = 4.27E+13 nM
|
[26] | |||
| Compound Name |
Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227378; BDBM50003015
Click to Show/Hide
|
||||
| Activity |
EC50 = 6.46E+13 nM
|
[25] | |||
| Compound Name |
(4-Hydroxy-4,4-diphenylbutyl)-[3-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]propyl]-dimethylazanium;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403592
Click to Show/Hide
|
||||
| Activity |
Ki = 8.32E+13 nM
|
[26] | |||
| Compound Name |
1,1-Diphenyl-4-piperazin-1-ylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258385
Click to Show/Hide
|
||||
| Activity |
Ki = 1.38E+14 nM
|
[26] | |||
| Compound Name |
4-[3-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]propyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256923
Click to Show/Hide
|
||||
| Activity |
Ki = 1.82E+14 nM
|
[26] | |||
| Compound Name |
4-[4-(1,1-Dimethylpiperidin-1-ium-4-yl)-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257804
Click to Show/Hide
|
||||
| Activity |
Ki = 2.29E+14 nM
|
[26] | |||
| Compound Name |
4-[4-(1-Methylpiperidin-4-yl)piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257174
Click to Show/Hide
|
||||
| Activity |
Ki = 2.51E+14 nM
|
[26] | |||
| Compound Name |
Diphenidol hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
difenidol hydrochloride; 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride; Diphenidol HCl; Celmidol; Satanolon; Verterge; Ansmin; Cerrosa; Maniol; Yesdol; 1,1-Diphenyl-4-piperidino-1-butanol hydrochloride; SKF 478 hydrochloride; SK&F 478-A; Diphenidol (hydrochloride); UNII-DG355XWQ4T; Diphenidol hydrochloride [USAN]; DG355XWQ4T; MLS000069816; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride; Difenidolin; Cefadol; Mecalmin; Pineroro; SMR000058238; Tenesdol; Wansar; C21H28ClNO; 1,1-DIPHENYL-4-(PIPERIDIN-1-YL)BUTAN-1-OL HCL; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride; Diphenidol hydrochloride (USAN); SKF 478-A; 1,1-diphenyl-4-piperidylbutan-1-ol, chloride; EINECS 221-850-0; NSC 23012; Difenidol, HCl; Cephadol (TN); Prestwick_886; Vontrol (TN); 1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride; alpha,alpha-Diphenyl-1-piperidinebutanol hydrochloride; alpha,alpha-Diphenylpiperidine-1-butanol hydrochloride; 1-Piperidinebutanol, alpha,alpha-diphenyl, hydrochloride; ACMC-209htu; Opera_ID_631; CHEMBL1529; Difenidol Hydrochloride,(S); MLS002222273; SCHEMBL195192; Difenidol hydrochloride (JP17); CTK8B1460; DTXSID10186248; HMS1568D06; BCP13983; HY-A0082; KS-000015TY; NSC23012; SK-478-A; AC-335; ANW-27376; MFCD00151479; NSC-23012; s4292; SBB006449; AKOS007930367; CCG-220252; DS-1389; MCULE-4932461593; AK-64514; BR-64514; ST055883; Diphenidol hydrochloride, >=98% (HPLC); AB0011648; D2062; FT-0667646; SW197007-3; A14244; D01318; S-4785; 1,1-Diphenyl-4-piperidino-1-butanolHydrochloride; 254D895; SR-01000721935; 1-Piperidinebutanol,.alpha.-diphenyl, hydrochloride; 1-Piperidinebutanol,.alpha.-diphenyl-, hydrochloride; J-018780; SR-01000721935-2; Q27276383; Z57257314; 1-(4-Hydroxy-4,4-diphenylbutyl)piperidine Hydrochloride; Butanol,1,1-diphenyl-4-(1-piperidyl)-, hydrochloride; .alpha.,.alpha.-Diphenyl-1-piperidinebutanol hydrochloride
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| Activity |
Ki = 3.55E+14 nM
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[26] | |||
| Compound Name |
4-[4-(4-Hydroxy-4,4-diphenylbutyl)-4-methylpiperazin-4-ium-1-yl]-1,1-diphenylbutan-1-ol;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402282
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| Activity |
Ki = 4.37E+14 nM
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[26] | |||
| Compound Name |
Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
PD 102807; CHEMBL59898; LSM-1888; SCHEMBL5071655; CTK8G2286; DTXSID20407355; HMS3268M09; HMS3412B04; HMS3676B04; BDBM50071171; AKOS024456739; L000465; SR-01000597510; J-014968; Q7118741; SR-01000597510-1; BRD-A89337244-001-01-1
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| Activity |
Ki = 9.12E+14 nM
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[26] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)piperidin-4-yl]piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403773
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| Activity |
Ki = 1.15E+15 nM
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[26] | |||
| Compound Name |
4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402207
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| Activity |
Ki = 2.75E+15 nM
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[26] | |||
| Compound Name |
4-(1-Methylpiperidin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254586
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| Activity |
Ki = 3.63E+15 nM
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[26] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. J Med Chem. 1998 Jul 2;41(14):2524-36. | ||||
| REF 2 | Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2897-902. | ||||
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| REF 4 | Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42. | ||||
| REF 5 | Structure-Based Design and Discovery of New M 2 Receptor Agonists. J Med Chem. 2017 Nov 22;60(22):9239-9250. | ||||
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| REF 7 | Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. J Med Chem. 1992 May 1;35(9):1541-50. | ||||
| REF 8 | N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg Med Chem Lett. 1995 Aug 17;5(16):1853-6. | ||||
| REF 9 | Bioisosteres of arecoline: 1,2,3,6-tetrahydro-5-pyridyl-substituted and 3-piperidyl-substituted derivatives of tetrazoles and 1,2,3-triazoles. Synthesis and muscarinic activity. J Med Chem. 1994 Nov 25;37(24):4085-99. | ||||
| REF 10 | Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. J Med Chem. 2006 Mar 23;49(6):1925-31. | ||||
| REF 11 | 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. J Med Chem. 1995 Feb 3;38(3):473-87. | ||||
| REF 12 | A rationale for the design and synthesis of m1 selective muscarinic agonists.. Bioorg Med Chem Lett. 1992 Aug;2(8):821-6. | ||||
| REF 13 | Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. Bioorg Med Chem. 2009 Dec 15;17(24):8174-85. | ||||
| REF 14 | Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. Bioorg Med Chem Lett. 2008 Jan 15;18(2):614-8. | ||||
| REF 15 | First fatty acylated dipeptides to affect muscarinic receptor ligand binding. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3363-8. | ||||
| REF 16 | Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. J Med Chem. 2008 Jul 10;51(13):3905-12. | ||||
| REF 17 | Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding. Bioorg Med Chem. 2008 Mar 15;16(6):3049-58. | ||||
| REF 18 | 1,4-dioxane, a suitable scaffold for the development of novel M1 muscarinic receptor antagonists. J Med Chem. 2012 Feb 23;55(4):1783-7. | ||||
| REF 19 | Synthesis and biological evaluation of Esaprazole analogues showing 1 binding and neuroprotective properties in vitro. Bioorg Med Chem. 2013 Jun 1;21(11):3334-47. | ||||
| REF 20 | Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. J Med Chem. 2003 Feb 27;46(5):856-67. | ||||
| REF 21 | Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6481-5. | ||||
| REF 22 | Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. J Med Chem. 2013 Feb 28;56(4):1693-703. | ||||
| REF 23 | Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3255-9. | ||||
| REF 24 | Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity. J Med Chem. 1998 Jan 1;41(1):109-16. | ||||
| REF 25 | Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists. Bioorg Med Chem. 2007 Jan 15;15(2):886-96. | ||||
| REF 26 | Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. | ||||
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