Target Validation Information
TTD ID	T14912
Target Name	Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Type of Target	Clinical trial
Drug Potency against Target	ALTENUSIN	Drug Info	IC50 = 4147.65 nM	[2]
	AMENTOFLAVONE	Drug Info	IC50 = 1634.07 nM	[2]
	BITHIONOL	Drug Info	IC50 = 1898.89 nM	[2]
	GNF-PF-1591	Drug Info	IC50 = 19733.2 nM	[2]
	GNF-PF-3955	Drug Info	IC50 = 3567.91 nM	[2]
	GNF-PF-5134	Drug Info	IC50 = 9187.06 nM	[2]
	MORIN	Drug Info	IC50 = 2988.26 nM	[2]
	NSC-180246	Drug Info	IC50 = 3944.08 nM	[2]
	NSC-66209	Drug Info	IC50 = 5376.77 nM	[2]
	QEDIIRNIARHLAQVGDSMDR	Drug Info	IC50 = 52 nM	[1]
	ROSMARINIC ACID	Drug Info	IC50 = 2025.72 nM	[2]
	Sch-45752	Drug Info	IC50 = 1491.9 nM	[2]
	SULFURETIN	Drug Info	IC50 = 1534.63 nM	[2]
	TW-37	Drug Info	IC50 = 1030 nM	[1]
References
REF 1	Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.
REF 2	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.

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