Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | (R)-2-{3'-[2-(3-dimethylamino-pyrrolidin-1-yl)-thiazol-4-yl]-biphenyl-yl}-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(6-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(5-fluoroindolin-1-yl)-4-(methylsulfonyl)butan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | 2-[2-(2-Biphenyl-4-yl-acetylamino)-3-mercapto-propionylamino]-5-guanidino-pentanoic acid [2-(4-hydroxy-phenyl)-1-phenethylcarbamoyl-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-2-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | ((S)-3-Methyl-1-{2-[4-(pyridin-4-ylmethoxy)-phenylamino]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(3-(methylsulfonyl)phenylamino)propan-2-yl)propanamide | Drug Info |
| CCKBR --- CCKAR | 1-[(R)-1-(4-Benzoyl-piperidine-1-carbonyl)-3-phenyl-propyl]-3-m-tolyl-urea | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-8-methyl-2-oxo-5-p-tolyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-methoxy-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | {[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-[2-(4-chloro-phenyl)-ethyl]-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | [(3R,5R)-2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid tert-butyl ester | Drug Info |
| CCKBR --- CCKAR | 3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-ureido}-N-(1H-tetrazol-5-yl)-benzamide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5R)-2-oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-Acetylamino-N-[1-[1-({[1-{1-[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-carboxy-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-pentylcarbamoyl]-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-bromobenzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | CCK7 analogue | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(2-aminoacetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)-N-(2-morpholinoethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(2-(1-chloro-7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | (4Z)-6-(3-Furyl)-4-({[5-(4-methylpiperazin-1-yl)pyrazin-2-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK1 --- GSK3 | 8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carboximidic acid butyl ester | Drug Info |
| CDK1 --- GSK3 | 6-(4-Chloro-phenyl)-7-methyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(thiophen-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-{[2-(methylamino)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(Benzo[d]1,3-dioxolylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CDK1 | 8-[(4-Methanesulfonyl-phenylamino)-methylene]-6,8-dihydro-thiazolo[5,4-e]indol-7-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-(methylsulfonyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(5-{3-[3-(2-Fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-2H-pyrazol-3-ylamino)-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2-(7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 8-[1-(4-methanesulfonylmethyl-phenylamino)-meth-(Z)-ylidene]-6,8-dihydro-thiazolo[5,4-e]indol-7-one | Drug Info |
| CDK2 --- CDK1 | GW335962X | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(dimethylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK4 | 4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-methoxy-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 4-(4-(2-amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino)phenol | Drug Info |
| CDK2 --- CDK4 | CHEMBL457888 | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-6-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- Cyclin E | 3-{[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-pyridin-3-ylmethyl-amino}-2-methyl-propionitrile | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((5-(furan-3-yl)thiophen-2-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 2-(5-((2-acetamidothiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(5-methylthiophen-2-yl)benzyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | [6-(4-Amino-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-tert-butyl-amine | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(4-Butyl-benzylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- GSK3 | (Z)-4-(5-(1-(2-imino-4-oxothiazolidin-5-ylidene)ethyl)furan-2-yl)benzenesulfonamide | Drug Info |
| CAII --- CAI | 1-(3-(3-bromophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| CDK4 --- Cyclin E | 5-{5-[3-(4-Methyl-piperazin-1-yl)-ureido]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-thiophene-2-carboxylic acid ethyl ester | Drug Info |
| CAII --- CAI | (2-{[(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| Ckit --- BRaf | 2-((2-(3-(1H-imidazol-1-yl)propylamino)pyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.