Target Validation Information
Target ID T13201
Target Name Carbonic anhydrase I
Target Type
Successful
Drug Potency against Target N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide Drug Info Ki = 40 nM
BENZOLAMIDE Drug Info Ki = 15 nM [1]
3-(4-sulfamoylphenyl)propanoic acid Drug Info Ki = 6690 nM [1]
GALLICACID Drug Info Ki = 3200 nM [2]
Phenoxyarsonous acid Drug Info Ki = 31.7 nM [3]
5-Chlorosalicylic Acid Drug Info Ki = 4160 nM [4]
4,6-Dinitro salicylic acid Drug Info Ki = 14850 nM [4]
4-azidobenzenesulfonamide Drug Info Ki = 3900 nM [5]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 164 nM [1]
PHENOL Drug Info Ki = 10200 nM [6]
P-Coumaric Acid Drug Info Ki = 1070 nM [2]
PARABEN Drug Info Ki = 920 nM [2]
4-(Methylhydrazino)-3-pyridinesulfonamide Drug Info Ki = 5620 nM [7]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide Drug Info Ki = 10000 nM [8]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide Drug Info Ki = 74 nM [9]
4-isothiocyanatobenzenesulfonamide Drug Info Ki = 5000 nM [10]
Phenyl Boronic acid Drug Info Ki = 58.6 nM [3]
CHLORIDE Drug Info Ki = 6 nM [3]
NSC-654077 Drug Info Ki = 4350 nM [11]
SALICYLATE Drug Info Ki = 9900 nM [12]
Syringic Acid Drug Info Ki = 4150 nM [2]
4-bromophenylboronic acid Drug Info Ki = 11700 nM [13]
IODIDE Drug Info Ki = 0.3 nM [3]
4-nitrophenyl phosphate Drug Info IC50 = 330 nM [14]
SULFATE Drug Info Ki = 63 nM [3]
SULFAMIDE Drug Info Ki = 0.31 nM [3]
4-Amino-3-iodo-benzenesulfonamide Drug Info Ki = 6000 nM [1]
Azide Drug Info Ki = 1200 nM [15]
Octyl sulfamate Drug Info Ki = 3.5 nM [16]
4-methylstyrylboronic acid Drug Info Ki = 12100 nM [13]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide Drug Info Ki = 36 nM [17]
2-Acetylamino-indan-5-sulfonic acid hydrate Drug Info Ki = 89 nM [17]
2-Amino-indan-5-sulfonic acid Drug Info Ki = 43 nM [17]
4-Amino-3-chloro-benzenesulfonamide Drug Info Ki = 9800 nM [1]
N-(pentafluorophenyl)sulfamide Drug Info Ki = 34 nM [18]
1-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 880 nM [19]
N-(4-Sulfamoyl-phenyl)-butyramide Drug Info Ki = 19300 nM [20]
2-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 600 nM [19]
SACCHARIN Drug Info Ki = 18540 nM [21]
2-nonylamido-5-sulfonamidoindane Drug Info Ki = 5330 nM [19]
2-propylamido-5-sulfonamidoindane Drug Info Ki = 825 nM [19]
Prop-2-ynyl 4-sulfamoylbenzoate Drug Info Ki = 4000 nM [22]
Pentanoic acid (4-sulfamoyl-phenyl)-amide Drug Info Ki = 17650 nM [20]
4-butylphenylboronic acid Drug Info Ki = 7900 nM [13]
4-methylphenyl-difluoromethanesulfonamide Drug Info Ki = 952 nM [23]
Phenethylboronic acid Drug Info Ki = 11400 nM [13]
Biphenyl-4-ylboronic acid Drug Info Ki = 3700 nM [13]
Styrylboronic acid Drug Info Ki = 12500 nM [13]
4-(Quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 10320 nM [7]
2,4-Disulfamyltrifluoromethylaniline Drug Info Ki = 5800 nM [1]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide Drug Info Ki = 9160 nM [7]
4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info Ki = 8400 nM [21]
2-butylamido-5-sulfonamidoindane Drug Info Ki = 875 nM [19]
2-acetamido-5-sulfonamidoindane Drug Info Ki = 2510 nM [19]
4-Hydrazino-benzenesulfonamide Drug Info Ki = 3900 nM [24]
3-Chloro-4-hydrazino-benzenesulfonamide Drug Info Ki = 2800 nM [24]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide Drug Info Ki = 10300 nM [7]
N-(4-Sulfamoyl-phenyl)-propionamide Drug Info Ki = 19700 nM [20]
4-Methoxy-3-pyridinesulfonamide Drug Info Ki = 7340 nM [7]
Sulfamic acid 4-sulfamoyloxy-butyl ester Drug Info Ki = 31 nM [25]
4-nitrophenyl-difluoromethanesulfonamide Drug Info Ki = 1130 nM [23]
PHENYLMETHANESULFONAMIDE Drug Info Ki = 1250 nM [23]
N-(4-Sulfamoyl-phenyl)-benzamide Drug Info Ki = 3300 nM [20]
Sulfamic acid 6-sulfamoyloxy-hexyl ester Drug Info Ki = 136 nM [25]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide Drug Info Ki = 68 nM [26]
2,3-dihydro-1H-indene-5-sulfonamide Drug Info Ki = 215 nM [17]
4-Methylthiopyridine-3-sulfonamide Drug Info Ki = 9030 nM [7]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide Drug Info Ki = 430 nM [20]
4-Benzythiopyridine-3-sulfonamide Drug Info Ki = 9090 nM [7]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 2400 nM [27]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 7010 nM [27]
2-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 3560 nM [19]
1-acetamido-5-sulfonamidoindane Drug Info Ki = 8.5 nM [17]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide Drug Info Ki = 10200 nM [8]
6-(aminomethyl)-2H-chromen-2-one Drug Info Ki = 99 nM [28]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester Drug Info Ki = 16450 nM [25]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide Drug Info Ki = 263 nM [26]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 10320 nM [7]
4-(Carbamolymethylthio)pyridine-3-sulfonamide Drug Info Ki = 9510 nM [7]
5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate Drug Info Ki = 730 nM [29]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide Drug Info Ki = 71 nM [26]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 1890 nM [27]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide Drug Info Ki = 4120 nM [30]
4-(2-Phenylacetamidomethyl)benzenesulfonamide Drug Info Ki = 75 nM [26]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide Drug Info Ki = 61 nM [26]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide Drug Info Ki = 67 nM [26]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide Drug Info Ki = 9800 nM [8]
4-(Cyanomethylthio)pyridine-3-sulfonamide Drug Info Ki = 11710 nM [7]
4-(Allylamino)-3-pyridinesulfonamide Drug Info Ki = 8860 nM [7]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide Drug Info Ki = 61 nM [26]
4-Amino-3-fluoro-benzenesulfonamide Drug Info Ki = 8300 nM [21]
[Cu(CN)2]- Drug Info Ki = 6900 nM [31]
Sodium trithiocarbonate Drug Info Ki = 8700 nM [32]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide Drug Info Ki = 4500 nM [33]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide Drug Info Ki = 109 nM [1]
PHENYLDIFLUOROMETHANESULFONAMIDE Drug Info Ki = 357 nM [23]
4-ethynyl benzene sulfonamide Drug Info Ki = 1080 nM [34]
2-(biphenyl-4-yl)vinylboronic acid Drug Info Ki = 10700 nM [13]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide Drug Info Ki = 48 nM [35]
N-hydroxysulfamide Drug Info Ki = 4050 nM [36]
PARAOXON Drug Info IC50 = 338 nM [14]
[Au(CN)2]- Drug Info Ki = 7700 nM [31]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 9.6 nM [37]
5-amino-1,3,4-thiadiazole-2-sulfonamide Drug Info Ki = 5900 nM [38]
4-(2-Amino-ethyl)-benzenesulfonamide Drug Info Ki = 2100 nM [39]
4-(hydroxymethyl)benzenesulfonamide Drug Info Ki = 55 nM [1]
3-Fluoro-4-hydrazino-benzenesulfonamide Drug Info Ki = 3300 nM [24]
NITRATE Drug Info Ki = 7 nM [3]
Pentane-1,5-diamine Drug Info Ki = 13300 nM [40]
Octane-1,8-diyl disulfamate Drug Info Ki = 378 nM [16]
2-oxo-2H-thiochromene-3-carboxylic acid Drug Info Ki = 12400 nM [28]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 5540 nM [27]
HERNIARIN Drug Info Ki = 5900 nM [28]
Decane-1,10-diyl disulfamate Drug Info Ki = 890 nM [16]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester Drug Info Ki = 1350 nM [25]
Aminobenzolamide derivative Drug Info Ki = 62 nM [41]
HYDROSULFIDE Drug Info Ki = 600 nM [15]
N-1,3,4-thiadiazol-2-ylsulfamide Drug Info Ki = 7420 nM [27]
CYANATE Drug Info Ki = 700 nM [15]
Carzenide Drug Info Ki = 3400 nM [42]
Curcumin Drug Info Ki = 2410 nM [6]
Cynooxide anion Drug Info Ki = 700 nM [43]
Decyl sulfamate Drug Info Ki = 530 nM [16]
4-methoxyphenylboronic acid Drug Info Ki = 10900 nM [13]
4-phenoxyphenylboronic acid Drug Info Ki = 6000 nM [13]
Beta-naphthylboronic acid Drug Info Ki = 6500 nM [13]
3-phenylprop-1-enylboronic acid Drug Info Ki = 8600 nM [13]
Carbamoyl phosphate disodium Drug Info Ki = 9400 nM [44]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 14600 nM [20]
4-(2-Phenylacetamidoethyl)benzenesulfonamide Drug Info Ki = 60 nM [26]
(4-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 273 nM [23]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 1660 nM [27]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide Drug Info Ki = 75 nM [26]
4-(2-Phenylacetamido)benzenesulfonamide Drug Info Ki = 108 nM [26]
2-Hydroxycinnamic acid Drug Info Ki = 3100 nM [6]
CATECHIN Drug Info Ki = 2420 nM [6]
INDISULAM Drug Info Ki = 31 nM [30]
ELLAGIC ACID Drug Info Ki = 2320 nM [2]
Hexane-1,6-diamine Drug Info Ki = 12600 nM [40]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 870 nM [45]
3-bromophenyl-difluoromethanesulfonamide Drug Info Ki = 1095 nM [23]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide Drug Info Ki = 7620 nM [7]
N-propynyl amidebenzenesulphonide Drug Info Ki = 6100 nM [22]
2-valproylamido-5-sulfonamidoindane Drug Info Ki = 4130 nM [19]
1-valproylamido-5-sulfonamidoindane Drug Info Ki = 810 nM [19]
N-(4-cyanophenyl)sulfamide Drug Info Ki = 20 nM [18]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 66 nM [28]
2-ethylamido-5-sulfonamidoindane Drug Info Ki = 3440 nM [19]
COUMARIN Drug Info Ki = 3100 nM [46]
6-Hydroxy-benzothiazole-2-sulfonic acid amide Drug Info Ki = 95 nM [47]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide Drug Info Ki = 6640 nM [7]
4-Ethoxy-3-pyridinesulfonamide Drug Info Ki = 6100 nM [7]
Sulfamic acid 3-sulfamoyloxy-phenyl ester Drug Info Ki = 79 nM [25]
PHENYLSULFAMATE Drug Info Ki = 2.1 nM [23]
(2-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 5200 nM [23]
5-Amino-[1,3,4]thiadiazole-2-thiol Drug Info Ki = 7100 nM [33]
4-Benzenesulfonylamino-benzenesulfonamide Drug Info Ki = 103 nM [20]
Sulfamic acid 7-sulfamoyloxy-heptyl ester Drug Info Ki = 145 nM [25]
1-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 770 nM [19]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide Drug Info Ki = 276 nM [11]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one Drug Info Ki = 510 nM [29]
4-Methanesulfonylamino-benzenesulfonamide Drug Info Ki = 125 nM [20]
BENZENESULFONAMIDE Drug Info Ki = 3300 nM [42]
2,4-dichloro-5-sulfamoylbenzoic acid Drug Info IC50 = 7700 nM [48]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide Drug Info Ki = 3440 nM [30]
COUMATE Drug Info Ki = 3450 nM [49]
FERULIC ACID Drug Info Ki = 2890 nM [2]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 59 nM [28]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 6800 nM [28]
N-[4-(trifluoromethyl)phenyl]sulfamide Drug Info Ki = 8000 nM [18]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid Drug Info Ki = 3720 nM [28]
Benzothiazole-2-sulfonic acid amide Drug Info Ki = 95 nM [50]
6-Amino-benzothiazole-2-sulfonic acid amide Drug Info Ki = 70 nM [51]
4-Amino-3-bromo-benzenesulfonamide Drug Info Ki = 6500 nM [1]
4-(2-Propynylthio)pyridine-3-sulfonamide Drug Info Ki = 8320 nM [7]
3-(3-Phenyl-ureido)-benzenesulfonamide Drug Info Ki = 1500 nM [20]
2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 9300 nM [28]
4-Hydrazino-3-pyridinesulfonamide Drug Info Ki = 7910 nM [7]
4,4'-thiodipyridine-3-sulfonamide Drug Info Ki = 11170 nM [7]
References
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REF 4Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
REF 5Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
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REF 21Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
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REF 24J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties.
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