miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-195-5p | ||||
miRNA Stemloop AC | MI0000489 | ||||
miRNA Stemloop ID | hsa-mir-195 | ||||
Sequence | uagcagcacagaaauauuggc | ||||
TTD Target(s) Regulated by This miRNA | Insulin receptor (INSR) | Successful Target | Target Info | [1] | |
Proto-oncogene c-Ret (RET) | Successful Target | Target Info | [2] | ||
Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | Target Info | [3] | ||
Cyclin-dependent kinase 4 (CDK4) | Successful Target | Target Info | [4] | ||
Cyclin-dependent kinase 6 (CDK6) | Successful Target | Target Info | [5] | ||
Apoptosis regulator Bcl-2 (BCL-2) | Successful Target | Target Info | [6] | ||
Fatty acid synthase (FASN) | Successful Target | Target Info | [7] | ||
Fibroblast growth factor-2 (FGF2) | Successful Target | Target Info | [7] | ||
Vascular endothelial growth factor A (VEGFA) | Successful Target | Target Info | [8] | ||
Checkpoint kinase-1 (CHK1) | Clinical trial Target | Target Info | [9] | ||
Ribosomal protein S6 kinase beta-1 (S6K1) | Clinical trial Target | Target Info | [10] | ||
Wee1-like protein kinase (WEE1) | Clinical trial Target | Target Info | [11] | ||
Apoptosis inhibitor survivin (BIRC5) | Clinical trial Target | Target Info | [12] | ||
Apoptosis regulator Bcl-W (BCL-W) | Clinical trial Target | Target Info | [13] | ||
Beta-secretase 1 (BACE1) | Clinical trial Target | Target Info | [14] | ||
G1/S-specific cyclin-D1 (CCND1) | Clinical trial Target | Target Info | [15] | ||
Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Target Info | [16] | ||
Cyclin-dependent kinase 8 (CDK8) | Clinical trial Target | Target Info | [17] | ||
Arachidonate 12-lipoxygenase (12-LOX) | Literature-reported Target | Target Info | [18] | ||
M-phase inducer phosphatase 1 (MPIP1) | Literature-reported Target | Target Info | [9] | ||
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Literature-reported Target | Target Info | [19] | ||
G1/S-specific cyclin-E1 (CCNE1) | Literature-reported Target | Target Info | [7] | ||
ADP-ribosylation factor-like protein 2 (ARL2) | Literature-reported Target | Target Info | [20] | ||
Cyclin D (CCND3) | Literature-reported Target | Target Info | [21] | ||
High mobility group protein HMG-I/Y (HMGA1) | Literature-reported Target | Target Info | [22] | ||
Methyl cpg binding protein 2 (MECP2) | Clinical trial Target | Target Info | [23] | ||
Wnt-7a protein (WNT7A) | Literature-reported Target | Target Info | [12] | ||
Yes-associated protein 1 (YAP1) | Literature-reported Target | Target Info | [24] | ||
Runt-related transcription factor 2 (RUNX2) | Literature-reported Target | Target Info | [16] | ||
Protein(s) Regulated by This miRNA | Bcl-2-like protein 11 | Regulated Protein | [23] | ||
Beclin 1-associated autophagy-related key regulator | Regulated Protein | [26] | |||
C-C motif chemokine 4 | Regulated Protein | [27] | |||
Calcium-binding protein 39 | Regulated Protein | [28] | |||
Cdc42-interacting protein 4 | Regulated Protein | [18] | |||
Cell division control protein 42 homolog | Regulated Protein | [30] | |||
Cingulin-like protein 1 | Regulated Protein | [18] | |||
E3 SUMO-protein ligase CBX4 | Regulated Protein | [31] | |||
Elastin | Regulated Protein | [32] | |||
F-box/WD repeat-containing protein 1A | Regulated Protein | [33] | |||
Keratin, type II cytoskeletal 7 | Regulated Protein | [34] | |||
Kinesin-like protein KIF21A | Regulated Protein | [18] | |||
Methyl-CpG-binding domain protein 1 | Regulated Protein | [35] | |||
Phosphatase and actin regulator 2 | Regulated Protein | [18] | |||
Protein disulfide-isomerase A6 | Regulated Protein | [18] | |||
Protein KIAA0100 | Regulated Protein | [36] | |||
Protein naked cuticle homolog 1 | Regulated Protein | [37] | |||
Ras-GEF domain-containing family member 1B | Regulated Protein | [18] | |||
Ski oncogene | Regulated Protein | [23] | |||
Solute carrier family 2, facilitated glucose transporter member 3 | Regulated Protein | [38] | |||
Sorting nexin-16 | Regulated Protein | [18] | |||
STE20-related kinase adapter protein beta | Regulated Protein | [18] | |||
TBCC domain-containing protein 1 | Regulated Protein | [21] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Regulated Protein | [19] | |||
Tuftelin | Regulated Protein | [18] | |||
References | |||||
REF 1 | Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells. FEBS Lett. 2014 Nov 3;588(21):3939-46. | ||||
REF 2 | Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. Leukemia. 2013 Mar;27(3):595-603. | ||||
REF 3 | MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways. Int J Oncol. 2016 Sep;49(3):1155-63. | ||||
REF 4 | Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells. FEBS Lett. 2012 Feb 17;586(4):442-7. | ||||
REF 5 | Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21. | ||||
REF 6 | microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun. 2010 Sep 17;400(2):236-40. | ||||
REF 7 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 8 | The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719. | ||||
REF 9 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 10 | miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer. Clin Cancer Res. 2015 Nov 1;21(21):4922-34. | ||||
REF 11 | microRNAs regulate human embryonic stem cell division. Cell Cycle. 2009 Nov 15;8(22):3729-41. | ||||
REF 12 | The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster. PLoS One. 2014 Feb 10;9(2):e84311. | ||||
REF 13 | MicroRNA-195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA. J Cell Physiol. 2015 Mar;230(3):535-45. | ||||
REF 14 | MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci. 2013 Feb 27;33(9):3989-4001. | ||||
REF 15 | MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 2008 May;18(5):549-57. | ||||
REF 16 | Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res. 2011 Apr 1;17(7):1722-30. | ||||
REF 17 | Tumor-suppressive microRNA-195-5p regulates cell growth and inhibits cell cycle by targeting cyclin dependent kinase 8 in colon cancer. Am J Transl Res. 2016 May 15;8(5):2088-96. | ||||
REF 18 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 19 | Genome-wide screening reveals that miR-195 targets the TNF-/NF-B pathway by down-regulating IB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology. 2013 Aug;58(2):654-66. | ||||
REF 20 | MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. Cell Death Dis. 2013 Jun 27;4:e695. | ||||
REF 21 | MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol. 2012 Mar;14(3):278-87. | ||||
REF 22 | Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1. Oncol Rep. 2016 Jul;36(1):376-82. | ||||
REF 23 | Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006 Apr 20;25(17):2537-45. | ||||
REF 24 | Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer. J Hematol Oncol. 2017 Mar 29;10(1):79. | ||||
REF 25 | Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006 Apr 20;25(17):2537-45. | ||||
REF 26 | Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury.Glia. 2013 Apr;61(4):504-12. | ||||
REF 27 | Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195.J Immunol. 2010 Nov 15;185(10):6253-64. | ||||
REF 28 | Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.PLoS One. 2012;7(7):e41574. | ||||
REF 29 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 30 | MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation.Cardiovasc Res. 2012 Sep 1;95(4):517-26. | ||||
REF 31 | MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma.Oncol Rep. 2015 Mar;33(3):1115-22. | ||||
REF 32 | Role of miR-195 in aortic aneurysmal disease.Circ Res. 2014 Oct 24;115(10):857-66. | ||||
REF 33 | The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One. 2013;8(3):e60155. | ||||
REF 34 | Identification of novel microRNA targets based on microRNA signatures in bladder cancer.Int J Cancer. 2009 Jul 15;125(2):345-52. | ||||
REF 35 | An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation.PLoS One. 2013;8(1):e51436. | ||||
REF 36 | MicroRNA-195 suppresses tumor cell proliferation and metastasis by directly targeting BCOX1 in prostate carcinoma.J Exp Clin Cancer Res. 2015 Sep 4;34:91. | ||||
REF 37 | MicroRNA-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1.Cell Biol Int. 2017 Mar;41(3):287-295. | ||||
REF 38 | MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression.FEBS Lett. 2012 Feb 17;586(4):392-7. | ||||
REF 39 | MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol. 2012 Mar;14(3):278-87. | ||||
REF 40 | Genome-wide screening reveals that miR-195 targets the TNF-/NF-B pathway by down-regulating IB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology. 2013 Aug;58(2):654-66. |
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