Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | 2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)ethanol | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-fluoro-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic Acid(trans-4-Amino-cyclohexyl)-amide | Drug Info |
| CDK2 --- CDK1 | 2-((2-(3-hydroxypropylamino)-9-isopropyl-9H-purin-6-ylamino)methyl)phenol | Drug Info |
| CDK2 --- CDK4 | 3,5-Dimethyl-4-[2-(3-nitro-phenylamino)-pyrimidin-4-yl]-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | (3-Bromo-5-trifluoromethyl-phenyl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | (4Z)-6-Fluoro-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-benzonitrile | Drug Info |
| CDK2 --- CSrc | 4-(thiazol-2-yl)-N-m-tolylpyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | N-{4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-1,3-thiazol-2-yl}-acetamide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-phenylfuran-3-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-(4-hydroxy-tetrahydro-pyran-4-ylethynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | N-[3-(4-Methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-isobutyramide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((6-(3-fluorophenyl)pyridin-3-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | {3-[3-Ethyl-4-oxo-1-(2,4,6-trichloro-phenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylmethyl]-phenyl}-acetic acid ethyl ester | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-(biphenyl-4-ylmethyl)-9-methyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | (3,5-Dimethoxy-phenyl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CAII --- CAI | 6-(Heptadecafluorooctane-1-sulfonylamino)-benzothiazole-2-sulfonic acid amide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(4-Dimethylamino-piperidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 2-ethyl-N-(4-sulfamoylbenzyl)butanamide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-pyridinium; perchlorate | Drug Info |
| COX2 --- 5LOX | 6-(7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-imidazo[2,1-b]thiazole | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | N-hydroxy-N-(3-(3-phenoxyphenyl)allyl)acetamide | Drug Info |
| CAII --- CAI | 3-methyl-2-propyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| COX2 --- 5LOX | Enofelast | Drug Info |
| CAII --- CAI | 6-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-benzothiazole-2-sulfonic acid amide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(2-chlorobenzyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | Benzothiazole-2-Sulfonic Acid Amide | Drug Info |
| CSrc --- CABL | N-(5-(3-chlorobenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-chloro-4-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | 3-(9-(2,6-dimethylstyryl)-6-(4-(dimethylphosphoryl)phenylamino)-9H-purin-2-yl)propanenitrile | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 4-sulfamoyl-benzylamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-6-(ethylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-[2-(Heptadecafluorooctane-1-sulfonylamino)-pyrimidin-4-ylamino]-benzenesulfonamide | Drug Info |
| CSrc --- CABL | (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(difluoro-phosphono-methyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- Ckit | N3-(6-aminopyridin-3-yl)-N1-(2-cyclopentylethyl)-4-methylisophthalamide | Drug Info |
| CAII --- CAI | N-[2-Iodo-4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-5-oxo-pentanoic acid anion | Drug Info |
| CAII --- CAI | N-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-benzamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-cyanomethyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | 5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate | Drug Info |
| EGFR --- HER2 | 6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)-N-(4-(benzyloxy)-3-chlorophenyl)quinazolin-4-amine | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenesulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CABL | 4-(2-Amino-ethylcarbamoyl)-benzenesulfonic acid 4-(2-nitro-vinyl)-phenyl ester HCl | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CSrc | 3N-methyl-2-(3-methylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
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