Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenesulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CABL | 4-(2-Amino-ethylcarbamoyl)-benzenesulfonic acid 4-(2-nitro-vinyl)-phenyl ester HCl | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CSrc | 3N-methyl-2-(3-methylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-2-((dimethylamino)methyl)acrylamide | Drug Info |
| CAII --- CAI | 6-[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid trans-2-piperidin-4-ylethyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methylcarbamate | Drug Info |
| CAII --- CAI | phenylarsonic acid | Drug Info |
| EGFR3 --- HER2 | GW784684X | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| EGFR3 --- HER2 | (7-Allyloxy-6-methoxyquinazolin-4-yl)-(3'-bromophenyl)amine hydrochloride | Drug Info |
| CAII --- CAI | 2-(3-chloro-4-hydroxyphenyl)-N-phenethylacetamide | Drug Info |
| EGFR3 --- HER2 | 4-[(4'-fluorobenzyl)amino]-6,7-diethoxyquinazoline hydrochloride | Drug Info |
| CAII --- CAI | Ethyl1-(2-methyl-1-(2-oxopropyl)-1H-indol-4-yl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorophenylamino)quinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CAII --- CAI | {[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 3-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | 4-(2-Trifluoromethanesulfonylamino-pyrimidin-4-ylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | [{2-[[(5-Chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | 4-Carbamoyl-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
| CAII --- CAI | 2,6-Diethyl-4-phenyl-1-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| CAII --- CAI | 4-(N'-Pentafluorobenzoyl-hydrazino)-benzenesulfonamide | Drug Info |
| CAII --- CAIX | 1-(4-sulfamoylphenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea | Drug Info |
| CAIX --- CAXII | N-(4-methyl-2-oxo-2H-chromen-7-yl)acetamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-1-(isopropylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(3,5-Dimethoxy-benzylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | (1-{1-Benzyl-2-oxo-2-[3-(3,4,4a,8a-tetrahydro-1H-isoquinolin-2-yl)-propylcarbamoyl]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-1-(6-fluoropyridin-2-ylamino)-2-oxoheptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-4-[1,2,4]triazol-1-yl-benzamide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(4-isopropyl-thiazole-2-sulfonylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-1-cyano-2-(4-(trifluoromethyl)phenyl)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(5-methyl-1H-imidazol-4-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(1-methylcyclohexyl)-1-oxopropan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | Quinoline-8-carboxylic acid{3-methyl-1-[(S)-(S)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclohexyl-1-((S)-1-(5-fluoroindolin-1-yl)-4-morpholinobutan-2-ylamino)-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 3-Bromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Nle-Gly-Trp-psi(CH2NH)-Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(naphthalene-1-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid.NH4OH; hydrate | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-2-(3,3-diphenyl-propionylamino)-3-1H-indol-3-yl-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2,4-dimethoxy-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-5-(3-chloro-phenyl)-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 5-(R)-Oxo-5-(4-phenylcarbamoyl-piperidin-1-yl)-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | N-[(Isopropyl-phenyl-carbamoyl)-methyl]-N-phenyl-2-(3-phenyl-ureido)-acetamide | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-3-(4-bromo-phenyl)-2-methyl-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | Boc-Phe(CH2-SO3Na)-gNle-mCIy-Trp-(N-Me)Nle-Asp-Phe-NH2 | Drug Info |
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