Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CCKBR --- CCKAR | CCK7 analogue | Drug Info |
| CCKBR --- CCKAR | H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H | Drug Info |
| CCKBR --- CCKAR | [(S)-1-((4aR,5R)-2-Benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester | Drug Info |
| CD135 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)urea | Drug Info |
| CD221 --- JNK1 | 2-(2-(4-chloro-5-(3-(dimethylamino)propoxy)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- CDK2 | 4-{N'-[7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-(8Z)-ylidene]-hydrazino}-benzenesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-benzoic acid | Drug Info |
| CDK1 --- CDK4 | (S)-2(1-Hydroxybut-2-ylamino)-6-[(2-pyridyl)methylamino]-9-iso-propylpurine | Drug Info |
| CDK1 --- GSK3 | 8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carboximidic acid benzyl ester | Drug Info |
| CDK1 --- GSK3 | SID526486 | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-6-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid | Drug Info |
| CDK2 --- AuroraA | 8-[(3-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[1-(4-sulfamoyl-phenylamino)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester | Drug Info |
| CDK2 --- CDK1 | CHEMBL451462 | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-hydroxy-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid 2,6-dimethoxy-benzylamide | Drug Info |
| CDK2 --- CDK1 | CHEMBL460087 | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-(S)-carboxylic AcidPiperidin-3-(S)-ylamide Hydrochloride | Drug Info |
| CDK2 --- CDK1 | CHEMBL460103 | Drug Info |
| CDK2 --- CDK4 | 3-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol | Drug Info |
| CDK2 --- CDK4 | N-[(4Z)-1,3-Dioxo-4-({[4-piperidin-1-ylmethyl]phenyl}amino)-methylene]-1,2,3,4-tetrahydroisoquinolin-6-yl]acetamide | Drug Info |
| CDK2 --- CDK4 | 4-(4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-ylamino)phenol | Drug Info |
| CDK2 --- CDK4 | [4-(2,4-Dimethyl-1H-pyrrol-3-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine | Drug Info |
| CDK2 --- Cyclin E | N-((1r,4r)-4-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)cyclohexyl)propionamide | Drug Info |
| CDK2 --- Cyclin E | (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-cyclopropyl-methanone | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(Cyclopropyl-methyl-amino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N-(3-Isopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-nitro-3-(1H-pyrrol-2-yl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N-[3-(2-benzoylamino-thiazol-4-ylmethyl)-5-cyanomethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide | Drug Info |
| CDK2 --- Cyclin E | (S)-tert-butyl 1-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)propan-2-ylcarbamate | Drug Info |
| CDK2 --- GSK3 | N-(6-(1H-pyrrol-2-yl)-1H-indazol-3-yl)cyclopropanecarboxamide | Drug Info |
| CDK2 --- GSK3 | N*5*-(4-Amino-cyclohexyl)-N*7*-(4-benzenesulfonyl-phenyl)-3-bromo-pyrazolo[1,5-a]pyrimidine-5,7-diamine | Drug Info |
| CAII --- CAI | 4-Chloro-6-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-benzene-1,3-disulfonic acid diamide | Drug Info |
| CDK4 --- Cyclin E | 1-Morpholin-4-yl-3-{4-oxo-3-[5-(piperazine-1-carbonyl)-thiophen-2-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-urea | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiophen-3-ylamino)methyl)-N-methylpicolinamide | Drug Info |
| CAII --- CAI | 6-Trifluoromethanesulfonylamino-benzothiazole-2-sulfonic acid amide | Drug Info |
| COX2 --- 5LOX | 2,6-Dimethyl-4-(2-m-tolyl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 5,10-dihydroindeno[1,2-b]indole-1,2-diol | Drug Info |
| COX2 --- 5LOX | 4-[2-(2-Bromo-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenecarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| COX2 --- 5LOX | furan L | Drug Info |
| CAII --- CAI | 4-((2R,5S,8R,11R,12S,15R,17S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2,3-dichloro-4,6-disulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | 1-(2-bromo-2-phenylethyl)-N-butyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 6-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenecarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| CSrc --- CABL | tert-butyl 3-(4-(6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenylamino)-3-oxopropylcarbamate | Drug Info |
| CAII --- CAI | [(S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-(3H-imidazol-4-yl)-propionylamino]-acetic acid | Drug Info |
| CSrc --- CABL | 1-[2-Chloro-2-(4-fluorophenyl)ethyl]-N-(pyridin-2-ylmethyl)-1Hpyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
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