Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6,7-difluoro-2-oxoquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (3S,10S,13S,17S)-3,17-dihydroxy-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(dicyclohexylmethyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| JNK1 --- JNK3 | ethyl 4-cyano-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 2,2,2-Trifluoro-1-[7-hydroxy-4-(4-hydroxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ylmethyl)-phosphonic acid | Drug Info |
| JNK1 --- JNK3 | methyl 4-methyl-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 3-(3-fluoro-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| JNK3 --- MAPK | 2-Hydroxy-N-[2-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-ylamino)-1-((S)-phenylmethyl)-ethyl]-acetamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-methoxy-N,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| MEP --- Cathepsin B | 1-((3-fluorophenyl)(p-tolyl)methylene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 5-ethyl-7-hydroxy-3-(4-hydroxyphenyl)-3H-quinazoline-4-thione | Drug Info |
| S5AR --- SRD5A2 | ((10R,13S,17S)-17-Diisopropylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)-phosphinic acid | Drug Info |
| MEP --- Cathepsin B | SID90419368 | Drug Info |
| Erbeta --- ER | (S)-2,3-Bis(4-hydroxyphenyl)propanenitrile | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid phenylamide | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-3-cyclopropyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)propanamide | Drug Info |
| Erbeta --- ER | 3-(6-hydroxynaphthalen-2-yl)benzo[d]isoxazol-5-ol | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-3-Hydroxymethyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid diisopropylamide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(naphthalene-2-sulfonylamino)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| Erbeta --- ER | [2-(4-Hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[3-(4-hydroxy-piperidin-1-yl)-propoxy]-6-methoxy-quinoline-3-carbonitrile | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| ABL --- Src | (6,7-Dimethoxy-quinolin-4-yl)-(3,4,5-trimethoxy-phenyl)-amine | Drug Info |
| Met --- VEGFR | 4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-methylpiperazine-1-carboxamide | Drug Info |
| Erbeta --- ER | (4-{4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl}-piperazin-1-yl)-(4-nitro-phenyl)-methanone | Drug Info |
| ABL --- Src | 4-(2,5-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-phenyl-2-thioxoimidazolidine-1-carboxamide | Drug Info |
| Erbeta --- ER | 1-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-ethylbenzamide | Drug Info |
| MMP1 --- MMP3 | (R)-2-((S)-4-(4-hydroxyphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| Erbeta --- ER | [4-(2-Piperidin-1-yl-ethoxy)-phenyl]-[5,6,7-trimethoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone; hydrochloride | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester | Drug Info |
| MMP1 --- MMP3 | (S)-N-(3,4-Dimethoxy-benzyl)-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide | Drug Info |
| Erbeta --- ER | 2-hydroxy-4,7-dimethoxyphenanthrene | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-(pyrrolidine-1-carbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thiophene-2-carboxamide | Drug Info |
| MMP1 --- MMP3 | (S)-2-[(R)-2-((R)-1-Hydroxy-1-hydroxycarbamoyl-ethyl)-5-phenyl-pentanoylamino]-3-phenyl-propionic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-((R)-3-Fluoro-pyrrolidin-1-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | S-(1,1-Diphenyl[4-iodophenyl]methyl)-L-cysteine | Drug Info |
| MMP1 --- MMP9 | 1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-pyridin-3-yl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| Erbeta --- ER | 4-bromo-2-(3-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-cyclohexylphenyl)diphenylmethylthio)propanoic acid | Drug Info |
| MMP13 --- MMP1 | 1-(4-But-2-ynyloxy-benzenesulfonyl)-4-(propane-1-sulfonyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4'-methyl-4-biphenylyl)urea | Drug Info |
| MMP13 --- MMP1 | 1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cyclohexanecarboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 2-Benzyl-4-(4-hydroxy-phenyl)-1,2,3,4-tetrahydro-isoquinolin-7-ol | Drug Info |
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