Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | CHEMBL1829442 | Drug Info |
| Erbeta --- ER | [5-Hydroxy-2-(4-hydroxy-phenyl)-naphtho[2,1-b]thiophen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | N-Hydroxy-2-(4-methoxy-benzenesulfonylamino)-2-methyl-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | [1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one | Drug Info |
| Erbeta --- ER | SID24807318 | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3'-Hydroxyphenyl)-3-methyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2-methylphenyl)-5,7-dihydroxy-4(3H)-quinazolinone | Drug Info |
| MMP13 --- MMP3 | N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexyl)-ethyl]-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Erbeta --- ER | CHEMBL1194563 | Drug Info |
| MMP2 --- HER2 | (6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829249 | Drug Info |
| Erbeta --- ER | [7-Hydroxy-4-(4-hydroxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-11-benzoyl-9-oxo-8-(3-p-tolyl-propyl)-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-methoxyphenylamino)-N-methyl-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Erbeta --- Mcl1 | SID48410082 | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-N-(4-((4-(2-(4-methylpyridin-3-yl)ethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-4-[2-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-piperazine | Drug Info |
| Ftase --- FPTase | [2-Butoxy-5-(3,4-dihydro-2H-quinoline-1-sulfonyl)-phenyl]-bis-(3H-imidazol-4-ylmethyl)-amine | Drug Info |
| MMP2 --- MMP13 | 5-Phenyl-2-(4-p-tolylethynyl-benzenesulfonylamino)-pent-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-ethyl-4-(3-hydroxyphenyl)-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(2-hydroxy-ethyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | (R)-2-(6-(benzyloxy)-N-isopentylnaphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3'-amino-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | ethyl 2-(3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetate | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4-(2,3-dimethylphenyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxy-1-(2-methoxyethyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(3-hydroxyphenyl)-2-(3-aminobutyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(1-Benzyl-1H-imidazol-4-yl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-N-benzyl-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-ethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanamine trihydrochloride | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({2'-methyl-5-[5-(3-nitro-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5-dimethylisoxazol-4-ylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Lck --- VEGFR | 1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(4-Methanesulfonyl-benzylsulfanyl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP14 | (S)-2-{4'-[(1H-Indole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-7-methoxy-5-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-nitro-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-N*1*-[(S)-1-(benzhydryl-carbamoyl)-2,2-dimethyl-propyl]-2-(3-biphenyl-4-yl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| VEGFR2 --- AuroraA | 4-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| Ftase --- FPTase | 1-[5-Chloro-3-(2,6-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-(3-methoxy-3-oxopropylamino)-1-oxopropan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| VEGFR2 --- CD135 | 1-(1-chloro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-8-yl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea | Drug Info |
| Ftase --- FPTase | (S)-2-{(E)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-acryloylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (3S,4S)-N-hydroxy-4-(4-((2-isopropylbenzofuran-3-yl)methyl)benzamido)pyrrolidine-3-carboxamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(3-morpholino-3-oxopropyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carboxylic acid pyridin-4-ylamide | Drug Info |
| MMP2 --- MMP3 | 4'-[(3R,5S)-5-Carboxy-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-nonyl]-biphenyl-4-carboxylic acid | Drug Info |
| VEGFR2 --- CDK1 | 5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-N-[2-(dimethylamino)ethyl]pyridine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-thiocyanato-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
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