Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-4-(4-phenylpiperidin-1-yl)but-1-en-1-yl]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenylcarbonyl)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-Chlorophenyl)-6-((4-chlorophenyl)(hydroxy)(1-ethyl-1H-imidazol-5-yl)methyl)-1-methylquinolin-2(1H)-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3,4-dimethoxyphenyl)-4-(4-methoxy-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 7-[(furan-2-yl)carbonyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-5-phenyl-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((cyclohexylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-1-pyridin-2-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | N-{1-[(3E)-4-{5-Cyano-4-[(4-methyl-1H-indol-5-yl)amino]-pyridin-3-yl}but-3-en-1-yl]piperidin-4-yl}benzenesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | GW575533A | Drug Info |
| FTase --- GTase | CHEMBL1179766 | Drug Info |
| CDK2 --- AuroraA | 8-[(3-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-(2-(dimethylamino)ethyl)piperazin-1-yl)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-[4-(2-Fluoro-5-hydroxy-4-methyl-phenylamino)-6-methoxy-quinazolin-7-yl]-2-methoxy-acetamide | Drug Info |
| H3 --- SERT | 6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bS,6S,11bR)-6-Methoxymethyl-3a,5b-dimethyl-1,3a,4,5b,6,11b-hexahydro-2H-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,5,8,11-tetraone | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide | Drug Info |
| H3 --- SERT | 4-(4-ethoxyphenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[(2,2,2-trifluoro-ethyl)-hydrazonomethyl]-pyrimidine-4,6-diamine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| H3 --- SERT | 3-(4-bromophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 4-(Bis(2-chloroethyl)amino)-N-(4-chlorophenyl)benzamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydropyrido[2,3-b][1,4]oxazin-1-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-methyl-3-(trifluoromethyl)phenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | 4-(3-chlorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(thiazol-2-ylsulfanyl)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-ethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea | Drug Info |
| HD6 --- HDAC4 | 1-(5-((4-methoxybenzyloxy)methyl)thiophen-2-yl)-2,2,2-trifluoroethanone | Drug Info |
| EGFR3 --- HER2 | 2-(3-(4-Methoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | [2-(Hydroxymethyl)-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl]methyl 2-(4-[2-(4-Methylphenyl)ethynyl]phenoxy)acetate | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | (+/-)-3-(3-(1-(1-ethylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-methoxyquinolin-6-yl)acrylamide | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-[2-hydroxy-6-(2-methyl-2H-tetrazol-5-yl)-benzoyl]-benzoic acid (R)-2-((S)-4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(2-chloro-4-cyano-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | N-Hydroxy-7-(8-isopentyl-2-oxo-2H-chromen-7-yloxy)heptanamide | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-2-fluoro-N-(2-morpholinoethyl)acrylamide | Drug Info |
| PKCA --- NPKC delta | 4-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | GW622055X | Drug Info |
| HDAC1 --- HD6 | N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(4-chloro-3-(trifluoromethyl)phenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| HDAC1 --- HD6 | 2,2,2-Trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-phenylpyrimidin-4-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-((2-bromo-4-(trifluoromethyl)benzamido)methyl)phenoxy)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
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