Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2,4,6-trimethylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 5-Trifluoromethoxy-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-(4-hydroxyphenyl)-5-methyl-3H-quinazolin-4-one | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-(4-Methoxy-3-((4-phenoxybenzamido)methyl)benzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-(4-Bromobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | 9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-ylethoxy)phenyl]-1,2,9,9a-tetrahydro-3H-fluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[4-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenoxy}-propionic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-1-tert-butyl-3-[1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-yl)thiourea | Drug Info |
| Erbeta --- ER | 7-Ethyl-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-9,10-dihydro-phenanthren-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(benzo[d]isoxazol-3-yl)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HER2 --- CD221 | N-(4-(4-amino-1-(1'-isopropyl-1,4'-bipiperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | (1S,12R)-5-hydroxy-10-methyltetracyclo[10.2.1.0^{1,9}.0^{3,8}]pentadeca-3(8),4,6,9-tetraen-11-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(1,2,3,4-Tetrahydro-quinolin-7-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 7-Phenyl-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(3-(3-hydroxy-4-(1-(hydroxyimino)propyl)-2-propylphenoxy)propylthio)phenyl)acetic acid | Drug Info |
| JNK1 --- JNK3 | 2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 4-bromo-2-(3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(thiazol-2-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-7-(pyridin-4-ylmethoxy)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{2-[1-(2-Biphenyl-4-yl-ethyl)-3-(2,4-dimethoxy-phenyl)-ureido]-ethyl}-phenylsulfanyl)-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(prop-1-enyl)picolinamide | Drug Info |
| Erbeta --- ER | 4-{8-Fluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-4-yl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((3-(4-tert-butylphenyl)-1-(2-methoxyethyl)-1H-pyrazole-5-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(4-hydroxybut-1-enyl)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(8-Aza-spiro[4.5]dec-8-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(cyclohexyloxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-5-(trifluoromethyl)quinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2R,3S)-5-Fluoro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-7-(3-(2,4-dichlorophenoxy)propoxy)-2-ethylchroman-2-carboxylic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-1,6-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(2-Aza-spiro[3.3]hept-2-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 5-bromo-N-(3-chloro-2-(4-cyclopropylpiperazin-1-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | 1-(4-hydroxyphenyl)-2-methyl-1H-indole-3-carbaldehyde oxime | Drug Info |
| JNK1 --- JNK3 | 8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((5-(4-(furan-3-yl)phenyl)-1-methyl-1H-pyrazole-3-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| Erbeta --- ER | 1-{2-[4-((R)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-ethyl}-pyrrolidine-2,5-dione | Drug Info |
| JNK1 --- JNK3 | SID103905196 | Drug Info |
| PR --- mRNA of AR | 5-Pentafluoroethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | 1-{2-[4-(4-Phenyl-2,3-dihydro-benzo[b]oxepin-5-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| JNK3 --- MAPK | 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-phenyl-phenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(3-piperidin-1-yl-propyl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | 5-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-3-m-tolyl-propionylamino]-ethoxymethyl}-2-fluoro-benzoic acid | Drug Info |
| PR --- mRNA of AR | (+/-)-1-(cyclopropylmethyl)-2-ethyl-1,2,3,6-tetrahydro-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| Erbeta --- ER | 10-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-10H-benzo[4,5]thieno[3,2-b]indol-7-ol | Drug Info |
| MEP --- Cathepsin B | SID535898 | Drug Info |
| PR --- mRNA of AR | 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-1-hydroxy-2-methylpropan-2-yl oxime | Drug Info |
| Erbeta --- ER | 2-(4-chlorophenyl)-2-oxoethyl 3-hydroxybenzoate | Drug Info |
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