Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (2S,3R)-2-{4-[2-(3-Aza-bicyclo[3.1.0]hex-3-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(2-ethyl-4-(3-(4-ethyl-2-(pyridin-2-yl)phenoxy)butoxy)phenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | 2,6-difluoro-N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 2-(3-tert-butyl-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| VEGFR2 --- AuroraA | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-ethoxy-3-(1-((5-methyl-2-o-tolyloxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | Drug Info |
| HER2 --- MMP-2 | (3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phenylpiperazine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| Erbeta --- ER | (S)-N-(1-(1-(4-(2-(piperidin-1-yl)ethoxy)benzyl)-5-hydroxy-3-methyl-1H-indol-2-yl)ethyl)-2-(2-phenyl-1H-indol-3-yl)acetamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-2-isopropoxypropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-hydroxypropylamino)picolinamide | Drug Info |
| Erbeta --- ER | 2-Bromo-4-((1R,2R,5R)-5-hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| VEGFR2 --- CDK1 | 4-(5-cyano-2-(4-(2-hydroxyethyl)phenylamino)pyrimidin-4-yl)benzenesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(5,6,7,8-Tetrahydro-naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(2-methoxyethylamino)picolinamide | Drug Info |
| Erbeta --- ER | 3,4-bis(4-hydroxyphenyl)butan-2-one | Drug Info |
| VEGFR2 --- CDK4 | 4-(2-butylpyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | SID26754830 | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-fluoroisoquinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | (1S,4R,5S)-4-(4-Hydroxy-phenyl)-6,9,9-trimethyl-3-oxa-bicyclo[3.3.1]non-6-en-1-ol | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(4-((methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(3-propylbiphenyl-4-yloxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 1-[4-(2,3-Diphenyl-pent-2-enyl)-phenoxymethyl]-piperidine | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-[4-(4,4''-bis-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethoxy)-phenoxy]-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(5-amino-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide | Drug Info |
| Erbeta --- ER | 7-(2-bromovinyl)-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-benzoyl-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | 4-(4-(naphthalen-2-yl)-1H-1,2,3-triazol-5-yl)pyridine | Drug Info |
| Erbeta --- ER | 3'-[4-(2-hexahydro-1-pyridinylethoxy)phenyl]-1,1'-spirobi[2,3-dihydro-1H-indene]-5,5'-diol; with hydrochloride | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3,5-dichlorobenzamide | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylmethoxy)picolinamide | Drug Info |
| Erbeta --- ER | SID14726689 | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3-(methoxy)-4-((2-(4-methyl-1-piperazinyl)ethyl)-oxy)phenyl)amino)pyrimido[5',4':5,6]-pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| JNK1 --- JNK3 | 2-(2-(3-methoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-7-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| JNK1 --- JNK3 | 4-(3-fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| Erbeta --- ER | 10-ethyl-3-hydroxy-8-methoxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3,4,5-trimethoxyphenyl)amino)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| MEP --- Cathepsin B | Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | Drug Info |
| Erbeta --- ER | CHEMBL242818 | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin-2-ylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
| MEP --- Cathepsin B | 6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| Erbeta --- ER | (E)-2-chloro-3,4'-dihydroxybiphenyl-4-carbaldehyde oxime | Drug Info |
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(3-phenoxy-propylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-ureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
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