Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- VEGFR1 | N-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP13 --- MMP1 | 4-(4'-Fluoro-biphenyl-4-sulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | {4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-yl]-phenyl}-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2,4-Dichloro-benzoylsulfamoyl)-benzoic acid methyl ester | Drug Info |
| MMP13 --- MMP1 | (4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-m-tolyl-butyl]-phosphinic acid | Drug Info |
| Erbeta --- ER | 3,8-Dihydroxy-5,11-dioxa-benzo[b]fluoren-10-one | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-3-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3-ylmethoxy)-benzenesulfonyl]-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 4-(benzo[d]isoxazol-3-yl)benzene-1,3-diol | Drug Info |
| VEGFR2 --- VEGFR1 | 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidine | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-4-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | (2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-(5-methyl-2-(prop-1-en-2-yl)hex-4-enyl)chroman-4-one | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-isopropylphenyl)benzamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| MMP13 --- MMP9 | 2-[(4'-Benzyloxy-biphenyl-4-sulfonyl)-methyl-amino]-5-bromo-N-hydroxy-3-methyl-benzamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(2-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| Erbeta --- Mcl1 | SID7969281 | Drug Info |
| VEGFR2 --- VEGFR1 | (3-Methyl-5-trifluoromethyl-phenyl)-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-yl]-amine | Drug Info |
| MMP2 --- MMP13 | 2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-propionamide | Drug Info |
| Ftase --- FPTase | 2-alpha,24,25-trihydroxylanostan-3-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2-chlorophenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Bis-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (1H-imidazol-2-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(2-methoxyphenyl)piperazin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Biphenyl-4-ylmethylsulfanyl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-1-(isopropylsulfonyl)-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2-methylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP14 | (S)-2-{4'-[(5-Methoxy-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-oxazolo[5,4,3-ij]quinolin-4-one | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-naphthalen-2-yl-phenyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | [((2E,6E,10E)-3,7,11,15-Tetramethyl-hexadeca-2,6,10,14-tetraenyloxycarbamoyl)-methyl]-phosphonic acid | Drug Info |
| MMP2 --- MMP3 | (R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methoxy-biphenyl-4-yl)-propyl]-succinamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-(2-phenylpropan-2-ylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropylamino)-3-methylbutoxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoic acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(4-Benzyl-phenyl)-2-butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP9 | N-benzyl-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 3-vFPP | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | 7-alGGPP | Drug Info |
| MMP2 --- MMP9 | (2R)-[(4-biphenylylsulfonyl) amino]-N-hydroxy-3-phenylpropionamide | Drug Info |
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