Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (S)-2-(4-((R)-2-amino-3-mercaptopropylamino)benzamido)-4-(methylthio)butanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-(methoxy)-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Benzoyl-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-isobutyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| MMP3 --- MMP8 | 2-(Hexadecane-1-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-(2-(2-aminoethylsulfonyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol | Drug Info |
| MMP3 --- MMP8 | 2-(5-Dimethylamino-naphthalene-1-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(3-fluoroazetidin-1-yl)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| MMP9 --- MMP3 | (3aR,4R,7R,7aR)-5-(4-But-2-ynyloxy-benzenesulfonyl)-7-hydroxy-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridine-4-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(4-nitro-phenylethynyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-benzyl-3-(3-hydroxyphenyl)-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| mTOR --- AKT | 2-amino-4-methyl-6-(6-methylpyridin-3-yl)-8-(tetrahydro-2H-pyran-4-yl)pteridin-7(8H)-one | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | methyl 7-tert-butyl-9H-carbazole-3-carboxylate | Drug Info |
| mTOR --- PI3K delta | 1-methyl-3-(4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | N-Cyclopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-(4-(2-aza-bicyclo[2.2.1]hept-5-en-2-yl)butyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(hydroxymethyl)phenyl]urea | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Chloro-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(5-chlorothiophen-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-pyridin-3-ylurea | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-sulfonic acid amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-Fluorobenzyl)-4-furan-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxamide | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 2-(2,4-Dichloro-benzenesulfonyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| FGFR --- VEGFR | 3-(3,5-Dimethoxy-phenyl)-N*7*-[3-(4-methyl-piperazin-1-yl)-propyl]-[1,6]naphthyridine-2,7-diamine | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-((5-chloropyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-phenyl]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Src --- VEGFR | CHEMBL199110 | Drug Info |
| NET --- SERT | CHEMBL422055 | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidazole | Drug Info |
| NET --- SERT | ((3S,4R)-1-Methyl-4-phenyl-pyrrolidin-3-yl)-pyridin-2-yl-methanone | Drug Info |
| Ftase --- FPTase | (S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methanesulfinyl-butyric acid | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(2-(piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(2-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(4-(2-hydroxypropan-2-yl)phenyl)pyrimidine-5-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(3-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantane-1-carbonyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-7-yl)pyrimidin-2-amine | Drug Info |
| NPKCdelta --- NPKCtheta | (2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one | Drug Info |
| Ftase --- FPTase | N-Cyclobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| VEGFR2 --- Ckit | N3-(6-acetamidopyridin-3-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
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