Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-(piperidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-benzo[1,3]dioxol-4-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| VEGFR2 --- Beta PDGFR | 5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-[1,2,4]triazol-1-yl-ethyl)-amide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(3'-methoxy-biphenyl-4-sulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| VEGFR2 --- CDK1 | 4-phenyl-2-(4-(pyrrolidin-1-ylmethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-6-methyl-4-oxo-heptanoic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-hydroxyethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 2-{4-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-benzenesulfonyl}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10-methyl-10,11-dihydro-5H-4,10-diaza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(3-bromophenyl)urea | Drug Info |
| MMP2 --- MMP9 | (S)-2-{(S)-3-Dimethylamino-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-N-hydroxy-propionamide | Drug Info |
| MMP2 --- MMP9 | 3-(4-{5-[4-(4-Bromo-phenoxy)-phenyl]-2,4,6-trioxo-hexahydro-pyrimidin-5-yl}-piperazin-1-yl)-propionic acid | Drug Info |
| Ftase --- FPTase | 2-{(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-methyl-2-oxo-ethyl}-isoindole-1,3-dione | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-fluorophenyl)-2-oxoimidazolidine-1-carboxamide | Drug Info |
| MMP2 --- MMP9 | (S)-1-(1-(hydroxyamino)-1-oxo-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propan-2-yl)-N-methylpiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(4,8-Dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| MMP2 --- MMP9 | (2S)-3-[(dimethylsulfamoyl)[4-(4-methylphenoxy)phenyl]amino]-N,2-dihydroxypropanamide | Drug Info |
| Ftase --- FPTase | FTI-277 | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3-fluoro-4-((2-(4-methyl-1-piperazinyl)ethyl)oxy)-phenyl)amino)pyrimido[5',4':5,6]-pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| MMP3 --- MMP8 | 7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 15,18-dimethyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- CSrc | 2-((3,5-dimethoxy)-4-((3-(4-methyl-1-piperazinyl)propyl)oxy)phenyl)amino)-6-(2,6-dimethylphenyl)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| MMP3 --- MMP8 | (R)-5-(4-Methoxy-benzenesulfonyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide | Drug Info |
| MMP3 --- MMP8 | (R)-2-(4-Methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 27 (FTI-2307) | Drug Info |
| VEGFR2 --- CSrc | N-(5-chloro-2-methoxypyridin-4-yl)-5-isopropoxy-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| MMP9 --- MMP3 | ((R)-2-Hydroxycarbamoyl-pyrrolidin-1-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester | Drug Info |
| Ftase --- FPTase | 16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-N-(4-{[4-(benzyloxy)-3,6-dioxocyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| mTOR --- AKT | N-(5-(2-Aminoimidazo[1,2-a]pyridin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- FGFR1 | N-[2-(3-tert-Butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide | Drug Info |
| mTOR --- PI3K gamma | (2,4-Difluorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-cyclohexyl-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| VEGFR2 --- TEK | 9-ethyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 5-(9-(1-((6-fluoropyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)-phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1,2-dimethyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-methyl-butyryl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| VEGFR2 --- TEK | 2-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazole | Drug Info |
| mTOR --- PI3K gamma | [4-(3-Methyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-(2-thienyl)urea | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((1-(3-chlorobenzoyl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| VEGFR2 --- TEK | 4-methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-((1S,5S,6S)-6-hydroxy-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea | Drug Info |
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