Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | [2-(4-{Cyclohexylidene-[4-(2-diisopropylamino-ethoxy)-phenyl]-methyl}-phenoxy)-ethyl]-diisopropyl-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-3-methylthiophene-2-carboxamide | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1-isobutyryl-1,4-diazepane-5-carboxamide | Drug Info |
| Erbeta --- ER | 4-(2-{4-[3-(4-Chloro-phenyl)-propylamino]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl}sulfamide | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-8-piperazin-1-ylmethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 7-(3-Fluoro-4-hydroxy-phenyl)-3-hydroxy-naphthalene-1-carbaldehyde | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate | Drug Info |
| MMP13 --- MMP1 | 4-benzylbenzyl(2-(cyclopropylmethyl)-3-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-oxopropyl)phosphinic acid | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-tert-butyl-4'-ethynyl-3-methylbiphenyl | Drug Info |
| MMP13 --- MMP1 | 4-(4-Methoxy-phenyl)-5-oxo-pyrrolidine-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-{4-[2-((S)-3-methyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-chroman-6-ol | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-benzyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-ethyl-9H-carbazole | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-(4-p-tolyloxy-phenoxy)-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(2,5-difluorophenyl)-4-phenyl-4-(3-(pyrrolidin-1-yl)propyl)-4,5-dihydro-1H-pyrazol-3-yl)ethanone | Drug Info |
| MMP13 --- MMP9 | 2-(N-benzyl-4-methoxyphenylsulfonamido)-3-(dimethylamino)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | 2-(3-Chloro-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-Hydroxyphenyl)-2-(alpha-aminopropionyl)-6-chloro-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| MMP2 --- HER2 | (6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 2-(3-Fluoro-4-hydroxy-phenyl)-6-hydroxy-quinoline-4-carbonitrile | Drug Info |
| Src --- VEGFR | CHEMBL383593 | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| Erbeta --- Mcl1 | SID846098 | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| MMP2 --- MMP13 | 2-Fluoro-N-hydroxy-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one | Drug Info |
| VEGFR2 --- AuroraA | 6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-(4-phenyl-piperidine-1-sulfonyl)-benzamide | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-3-methyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| VEGFR2 --- CD135 | N-(3-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)phenyl)-4-morpholino-3-(trifluoromethyl)benzamide | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(cyclopentylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| VEGFR2 --- CDK1 | N,N-diethyl-2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxamide | Drug Info |
| MMP2 --- MMP13 | N-[1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-1-phenyl-ethyl]-benzamide | Drug Info |
| Ftase --- FPTase | (+)1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-N-(4-((4-(2-methyl-4-(methylsulfonyl)phenethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)formamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-piperidin-4-ylmethyl-piperidine-1-carboxamidine | Drug Info |
| VEGFR2 --- Ckit | 1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-1-m-tolylurea | Drug Info |
| MMP2 --- MMP13 | 1-(but-2-ynyl)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-phenyl-propan-1-one | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-(trifluoromethyl)phenyl)malonamide | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-4-(3-methoxy-phenyl)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-butyl]-phosphinic acid | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| MMP2 --- MMP3 | (4-Benzoylamino-butyl)-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-phenoxybenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.