Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | [4-Chloro-5-hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-yl]-acetonitrile | Drug Info |
| MEP --- Cathepsin B | (S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide | Drug Info |
| PR --- mRNA of AR | 7-Ethyl-6-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | 4-(1-Butyl-1,7a-dihydro-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | Drug Info |
| MEP --- Cathepsin B | N-[2-(3-Morpholin-4-yl-ureido)-1-naphthalen-2-ylmethyl-2-oxo-ethyl]-2-[(E)-2-(naphthalene-2-sulfonyl)-vinylamino]-4-phenyl-butyramide | Drug Info |
| PR --- mRNA of AR | 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Thiomorpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-[3-(2-trifluoromethyl-phenyl)-ureido]-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (2-(4-butylphenyl)-6-hydroxybenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| Met --- VEGFR | 1-(3-fluoro-4-(2-(pyrimidin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(thiophen-3-yl)-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | SID24396502 | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | 1,6,8,8,10-Pentamethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-methyl-2-pyrrolidin-1-yl-propoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-methyl-N3-phenylmalonamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-(1-cyclohexyl-2-oxo-pyrrolidin-3-yl)-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-(4-p-tolyloxy-butyl)-succinamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid benzyl ester | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2-methylphenyl)-2-(4-hydroxyphenyl)propanenitrile | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-[(S)-1-(1H-Benzoimidazol-2-yl)-3-methyl-butyl]-N*4*-hydroxy-2-isobutyl-succinamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid m-tolylamide | Drug Info |
| Erbeta --- ER | SID4248371 | Drug Info |
| MMP1 --- MMP3 | N-hydroxy-2-[[methyl(phenyl)phosphoryl](2-phenylethyl)amino]acetamide | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-difluoro-acetic acid | Drug Info |
| Erbeta --- ER | rac-N-cyclopropyl-N-(2-(2,6-difluorophenyl)-2-hydroxypropyl)-4-hydroxybenzenesulfonamide | Drug Info |
| MMP1 --- MMP9 | 2-biphenyl-4-yl-N-tert-butyl-2-[(3R,6S)-3-mercaptomethyl-6-(4-nitro-benzyl)-2,5-dioxo-piperazin-1-yl]-acetamide | Drug Info |
| S5AR --- SRD5A2 | 7-Bromo-9,10-dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-(4-(2-((3R,4S)-3,4-dimethylpyrrolidin-1-yl)ethoxy)phenyl)-3-(4-hydroxyphenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| MMP1 --- MMP9 | 1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-thiophen-2-yl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-1,4a,6a,10-tetramethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-chroman-6-ol | Drug Info |
| MMP13 --- MMP1 | (3S,4R)-4-[4-(2-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid o-tolylamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-inden-1-one | Drug Info |
| MMP13 --- MMP1 | 2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)pentyl(4-benzylbenzyl)phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | 8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| Erbeta --- ER | 6-isobutyl-4,10-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| MMP13 --- MMP1 | 4-[4-(4-Fluoro-phenylsulfanyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-10,13-Dimethyl-3-oxo-4-trifluoromethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid tert-butylamide | Drug Info |
| Erbeta --- ER | 1-(4-hydroxyphenyl)-1H-indole-3-carbaldehyde oxime | Drug Info |
| MMP13 --- MMP1 | 4-[4-(Pyridin-3-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2-Bromo-4-chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3-(4-fluorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one | Drug Info |
| MMP-13 --- MMP-1 | (R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-propane-1-thiol | Drug Info |
| ABL --- Src | 4-(2-Bromo-3,4,5-trimethoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(3-Hydroxy-phenyl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-imidazol-1-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
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