Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP-13 --- NEP | (2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1{[(benzyloxy)carbonyl]amino}ethyl)Phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl}amino)-3-phenyl Propanoic Acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-[(E)-2-(4-nitro-phenyl)-vinyl]-benzonitrile | Drug Info |
| VEGFR2 --- FGFR1 | 3-(3,5-Dimethoxy-phenyl)-N*7*-[3-(4-methyl-piperazin-1-yl)-propyl]-[1,6]naphthyridine-2,7-diamine | Drug Info |
| NET --- SERT | (3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid 4-[(4-trifluoromethyl-benzoylamino)-methyl]-benzylamide | Drug Info |
| Ftase --- FPTase | N-(6-cyano-1-((1-methyl-1H-imidazol-5-yl)methyl)-1,2,3,4-tetrahydroquinolin-3-yl)-1-methyl-N-(2-(thiophen-3-yl)ethyl)-1H-imidazole-4-sulfonamide | Drug Info |
| VEGFR2 --- TEK | N-(6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)benzthiazol-2-yl)methanesulfonamide | Drug Info |
| NET --- SERT | 2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylamine | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2-(2,2-diphenyl-ethyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- TEK | 7-Cyclopentyl-6-methyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)-2-methylphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-(4-cyanobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpiperazin-1-yl)methyl)styryl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| VEGFR2 --- TEK | N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((2-hydroxyethylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-6-(trifluoromethyl)phenyl)urea | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5'-((4-methylpiperazin-1-yl)methyl)-3,3'-bipyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-({(S)-2-[(S)-2-(2-3H-imidazol-4-yl-acetylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-butyric acid | Drug Info |
| CCKBR --- CCKAR | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[3-(1H-indol-3-yl)-2-(2-{2-[3-(4-sulfonyl-oxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-propionylamino]-4-methyl-pentanoylamino}-succinamic acid | Drug Info |
| VEGFR2 --- TEK | isopropyl 5-methyl-3-oxo-9-propyl-2,3,5,7,8,9-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-12-ylcarbamate | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin-1-ylmethylamino)propoxy)phenyl)nicotinonitrile | Drug Info |
| H3 --- SERT | 3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine hydrochloride | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,2-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| VEGFR2 --- TEK | 4-fluoro-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| PI3K gamma --- DNPK1 | 3-(3-aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| H3 --- SERT | N-cyclopropyl-N-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)cyclopropanamine | Drug Info |
| EGFR3 --- HER2 | 1-(2-chloroethyl)-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(3-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| H3 --- SERT | (1-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperidin-4-yl)methanol | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(5-(4-ethylpiperazin-1-yl)pent-1-ynyl)-6-methylpyrimidin-4-amine | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-3-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-(benzo[b]thiophen-3-ylmethyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| H3 --- SERT | N-(4-(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)but-3-ynyl)cyclopropanamine | Drug Info |
| EGFR3 --- HER2 | 2-[5-((E)-2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid anion | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957841 | Drug Info |
| HD6 --- HDAC2 | 4-((2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | Pentanedioic acid 4-methoxy-phenyl ester 4-((E)-2-nitro-vinyl)-phenyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-N-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-isopropyl-cyclopentyl ester | Drug Info |
| HDAC1 --- HD6 | 4-dimethylamino-N-[3-(2-mercaptoacetylamino)propyl]benzamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((3-((dimethylamino)methyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| VEGFR2 --- VEGFR1 | Dimethyl-{3-[4-(3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidin-6-yl)-phenoxy]-propyl}-amine | Drug Info |
| PKCA --- NPKC delta | 23-ethyl-17,20-dioxa-4,14,23,26-tetraazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 5-(sulfamoylamino)-1-(5-(thiophen-2-yl)-1H-benzo[d]imidazol-2-yl)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | N4-(3-bromophenyl)quinazoline-4,6-diamine | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.