Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(3-(2-morpholinoethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(butyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (2S)-2,6-diamino-N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)hexanamide | Drug Info |
| VEGFR2 --- Ckit | 1-cyclohexyl-3-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea | Drug Info |
| Ftase --- FPTase | (4-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| MMP3 --- MMP8 | 2-Benzenesulfonyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamoyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 15,16-dibenzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP3 --- MMP8 | (S)-N-[3-Hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-3-phenylacetylamino-succinamic acid tert-butyl ester | Drug Info |
| VEGFR2 --- Cmet | 3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluoro-N-phenylbutanamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(4-Trifluoromethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-hydroxyphenyl)malonamide | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(2-methyl-allyl)-benzenesulfonamide | Drug Info |
| MMP9 --- MMP3 | (2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl}-3-[formyl(hydroxy)amino]-2-[(5-methyl-2-thienyl)methyl]hexanamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-methylbenzamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-[2-(2-hydroxy-ethoxy)-ethyl]-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-3-cyclopentylpropanamide | Drug Info |
| Ftase --- FPTase | (S)-2-({(S)-2-[2-(2-Mercapto-ethylamino)-acetyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-thiophen-2-ylurea | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-4-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3-Bromo-10-methoxy-8-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(oxetan-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (+)-1-((1R,3R)-3-hydroxycyclopentyl)-3-(4-methoxyphenyl)-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(3,5-Difluoro-benzyloxy)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 5-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| VEGFR2 --- FGFR1 | N-[2-(3-tert-Butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(4-hydroxy-butyl)-acetamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea | Drug Info |
| VEGFR2 --- HDAC1 | N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methanesulfonyl-benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Chlorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(5-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)-1-oxo-2-pyridyloxy)-1H-benzimidazol-2-yl)-carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(6-oxo-heptanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| NET --- SERT | cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-nitrobenzyl)amine | Drug Info |
| VEGFR2 --- TEK | N-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]furan-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| NET --- SERT | 4-(4-Fluoro-indan-2-ylmethyl)-4,5-dihydro-1H-imidazole | Drug Info |
| VEGFR2 --- TEK | 1-(2-fluoro-5-methylphenyl)-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']terphenyl-3-carboxylic acid 22 (FTI-2195) | Drug Info |
| NPKCdelta --- NPKCtheta | Octanoic acid (E)-(1S,5S,9S,11S,15R,19R,24S)-11-tert-butyl-1,15-dihydroxy-19-((R)-1-hydroxy-ethyl)-23-methoxycarbonylmethylene-2,2-dimethyl-17-oxo-6,12,18,25,26-pentaoxa-tricyclo[19.3.1.1*5,9*]hexacos-3-en-24-yl ester | Drug Info |
| VEGFR2 --- TEK | N-(4-phenoxyphenyl)-3-(3-(4-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-yl)pyridin-2-ylamino)benzamide | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethylbutyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[(3S)-3-Aminopyrrolidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(1H-pyrrol-1-yl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-4-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
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