Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid ethyl ester | Drug Info |
| MMP-13 --- NEP | (2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1{[(benzyloxy)carbonyl]amino}ethyl)Phosphinyl]-(2S)-2-[(3-phenylisoxazol-5-yl)methyl]-1-oxopropyl}amino)-3-phenyl Propanoic Acid | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-3-pyridinecarboxamide | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-[(E)-2-(4-nitro-phenyl)-vinyl]-benzonitrile | Drug Info |
| NET --- SERT | (3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid 4-[(4-trifluoromethyl-benzoylamino)-methyl]-benzylamide | Drug Info |
| VEGFR2 --- TEK | rac-9-(2-ethoxyethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | N-(6-cyano-1-((1-methyl-1H-imidazol-5-yl)methyl)-1,2,3,4-tetrahydroquinolin-3-yl)-1-methyl-N-(2-(thiophen-3-yl)ethyl)-1H-imidazole-4-sulfonamide | Drug Info |
| NET --- SERT | 2-(2,3-Dihydro-1H-indol-5-yl)-1,1-dimethyl-ethylamine | Drug Info |
| VEGFR2 --- TEK | N-(4-fluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-isopropylbenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2-(2,2-diphenyl-ethyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)-2-methylphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-(4-cyanobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpiperazin-1-yl)methyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(methoxyimino)-2-methylpropyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((2-hydroxyethylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | rac-9-(cyclohexylmethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5'-((4-methylpiperazin-1-yl)methyl)-3,3'-bipyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-({(S)-2-[(S)-2-(2-3H-imidazol-4-yl-acetylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-butyric acid | Drug Info |
| CCKBR --- CCKAR | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[3-(1H-indol-3-yl)-2-(2-{2-[3-(4-sulfonyl-oxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-propionylamino]-4-methyl-pentanoylamino}-succinamic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin-1-ylmethylamino)propoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(3,4-dichlorophenyl)benzamide | Drug Info |
| H3 --- SERT | 3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine hydrochloride | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,2-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- DNPK1 | 3-(3-aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)isothiazole-3-carboxamide | Drug Info |
| H3 --- SERT | N-cyclopropyl-N-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)cyclopropanamine | Drug Info |
| EGFR3 --- HER2 | 1-(2-chloroethyl)-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea | Drug Info |
| PI3K gamma --- PI3K delta | 2-(3-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethoxy)ethyl)-5-(2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | Drug Info |
| H3 --- SERT | (1-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperidin-4-yl)methanol | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(5-(4-ethylpiperazin-1-yl)pent-1-ynyl)-6-methylpyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-(benzo[b]thiophen-3-ylmethyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(3-(2-(pyridin-4-yl)ethyl)pyridin-4-yl)-N-(3-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | N-(4-(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)but-3-ynyl)cyclopropanamine | Drug Info |
| EGFR3 --- HER2 | 2-[5-((E)-2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid anion | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957841 | Drug Info |
| VEGFR2 --- VEGFR1 | GW577921A | Drug Info |
| HD6 --- HDAC2 | 4-((2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | Pentanedioic acid 4-methoxy-phenyl ester 4-((E)-2-nitro-vinyl)-phenyl ester | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-isopropyl-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(2-chloro-4-nitro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | 4-dimethylamino-N-[3-(2-mercaptoacetylamino)propyl]benzamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((3-((dimethylamino)methyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 23-ethyl-17,20-dioxa-4,14,23,26-tetraazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-(3-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 5-(sulfamoylamino)-1-(5-(thiophen-2-yl)-1H-benzo[d]imidazol-2-yl)pentylcarbamate | Drug Info |
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