Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclobutylamino)picolinamide | Drug Info |
| Erbeta --- ER | {6-Hydroxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}-phenyl-methanone | Drug Info |
| JNK1 --- JNK3 | 4-(8-(2-fluorophenylamino)-2-(4-methoxyphenylamino)-9H-purin-9-yl)cyclohexanol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(3-(2-(4-chlorophenyl)-4-methylthiazole-5-carboxamido)piperidin-1-yl)benzoic acid | Drug Info |
| Erbeta --- ER | SID49676928 | Drug Info |
| JNK1 --- JNK3 | 9-cyclopentyl-N8-(2-fluorophenyl)-N2-(4-methoxyphenyl)-9H-purine-2,8-diamine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(4-(2-hydroxyethyl)-1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| Erbeta --- ER | 4-[6-(Methyl-phenethyl-amino)-4-phenyl-pyridin-2-yl]-phenol | Drug Info |
| JNK1 --- JNK3 | CHEMBL203059 | Drug Info |
| PR --- mRNA of AR | 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid amide | Drug Info |
| MEP --- Cathepsin B | 2-(3-phenyl-1-(3-(trifluoromethyl)phenyl)allylidene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 2'-hydroxy-3-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| Erbeta --- ER | 1-[4-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-2-(naphthalene-1-sulfonylamino)-3-phenyl-propionamide | Drug Info |
| PR --- mRNA of AR | 1,2,3,6-tetrahydro-1-propyl-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| Erbeta --- ER | 4,7-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| MEP --- Cathepsin B | 2-((3,5-dichlorophenyl)(thiophen-2-yl)methylene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | 4'-Isoxazol-5-yl-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | rac 2-((4-cyano-3-(trifluoromethyl)phenyl)(2,2,2-trifluoroethyl)amino)-N,N-dimethylacetamide | Drug Info |
| Erbeta --- ER | 2-(4-(ethylsulfonyl)phenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)benzo[b]thiophen-6-ol | Drug Info |
| MEP --- Cathepsin B | (E)-methyl4-(2-((R,Z)-3-((4-chloro-2-(trifluoromethyl)phenylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate | Drug Info |
| PR --- mRNA of AR | 1,6,8,8,10-Pentamethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | (4R,5S)-2,2,4-Trimethyl-5-phenyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| Met --- VEGFR | 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide | Drug Info |
| PR --- mRNA of AR | Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | 2-(4-(7-(2-fluoro-4-(3-oxo-3-(phenylamino)propanamido)phenoxy)thieno[3,2-b]pyridine-2-carbonyl)-1H-imidazol-1-yl)acetic acid | Drug Info |
| Renin --- Cathepsin D | (S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-{(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-[(quinoline-2-carbonyl)-amino]-succinamide | Drug Info |
| Erbeta --- ER | 6-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[4-(4-propyl-phenoxy)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,4-triazol-1-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-2-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-3-methyl-1-(5-phenyl-1H-imidazol-2-yl)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-propylcarbamoyl-phenyl ester | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-(thiophen-2-yl)benzo[d]oxazol-5-ol | Drug Info |
| MMP1 --- MMP3 | 1N-phenyl-2-{1-[1-amino-(1R)-ethylcarboxamido]-4-phenylbutylcarboxamido}-4-methyl-(2S)-pentanamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-methoxycarbonyl-phenyl ester | Drug Info |
| Erbeta --- ER | 1-(4-Fluoro-phenyl)-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butylnonanamide | Drug Info |
| S5AR --- SRD5A2 | 7-((E)-Styryl)-9,10-dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-methyl-thiazol-4-ylmethyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP1 --- MMP9 | Furan-3-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(4'-tert-butyl-4-(trifluoromethyl)biphenyl-2-yl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | [2-(4-{Cyclohexylidene-[4-(2-diisopropylamino-ethoxy)-phenyl]-methyl}-phenoxy)-ethyl]-diisopropyl-amine | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1-isobutyryl-1,4-diazepane-5-carboxamide | Drug Info |
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