Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-isopropyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 4-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbaldehyde | Drug Info |
| Erbeta --- ER | (2S,3R)-7-Hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(4-chloro-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-[1,4]diazepan-1-yl)-propoxy]-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 9a-benzyl-6-methyl-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one | Drug Info |
| MMP13 --- MMP9 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-2-propylpentanamide | Drug Info |
| PDGFR --- Src | 8-Methyl-2-(pyridin-4-ylamino)-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Erbeta --- ER | CHEMBL2135534 | Drug Info |
| MMP2 --- HER2 | (1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)-5,7-dimethylbenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP2 --- MMP1 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phenoxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID534102 | Drug Info |
| Erbeta --- mRNA of AR | SID4243681 | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-(4-phenyl-piperazin-1-yl)-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL254192 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-methoxy-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829250 | Drug Info |
| Ftase --- FPTase | 4-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester | Drug Info |
| MMP2 --- MMP13 | N-benzyl-1-(4-(1-cyclopropyl-4-(hydroxycarbamoyl)piperidin-4-ylsulfonyl)phenyl)-N-methylpiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(trifluoromethyl)-9H-pyrido[3,4-b]indole | Drug Info |
| Ftase --- FPTase | 3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-2-(tetrahydro-2H-pyran-4-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-chlorophenyl)-N,N,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP13 | 2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-5-phenyl-pent-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(pyridin-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-methoxy-2-methylphenyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-benzhydryl 2-amino-3-(tritylthio)propanoate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(5-oxo-hexanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(2-methyl-3'-trifluoromethoxy-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-benzyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclopropylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP3 | Methyl-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-Ethyl-1-(3-hydroxyphenyl)-2-propyl-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP3 | (R)-3-{(S)-2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-6-p-tolyl-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-5-methyl-2-(thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorophenoxy)phenyl)methan-2-ylsulfonamido)-2-(cis-2,6-dimethylmorpholino)-N-hydroxypropanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-5,7-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
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