Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 4-(Thiiran-2-ylmethylsulfonyl)phenyl propane-1-sulfonate | Drug Info |
| VEGFR2 --- VEGFR1 | 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-4-(3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyridin-2-one | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-hydroxy-butyramide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[4-(4-nitro-phenyl)-butyrylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(4,5-Dibromo-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-3-yl)-propan-1-one | Drug Info |
| MMP3 --- MMP8 | 2-(4'-Dimethylamino-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-2-{2-[3-(4-Methoxy-benzyl)-3H-imidazol-4-yl]-acetylamino}-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | [2-(4-Bromo-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | (S)-2-((4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino)-3-phenyl-propionic acid | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-tert-butylphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(phenylsulfonamido)pyridin-3-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | N-[3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-phenyl]-benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Hydroxymethylphenyl)-3-[4-(3-isopropyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]urea | Drug Info |
| Ftase --- FPTase | 3-[(R)-3-(1,5-Dimethyl-hexyl)-3a-methyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-yl]-propionic acid | Drug Info |
| mTOR --- PI3K gamma | 2-((5-bromo-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | [4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-quinolin-8-yl-methanone | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| NET --- SERT | CHEMBL1192697 | Drug Info |
| Ftase --- FPTase | 1-Methyl-1H-pyrazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide | Drug Info |
| NET --- SERT | 8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(Pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-[3-(2-hydroxy-ethoxy)-phenoxy]-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-4-(4-phenylpiperidin-1-yl)but-1-en-1-yl]nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Chlorophenyl)-6-((4-chlorophenyl)(hydroxy)(1-ethyl-1H-imidazol-5-yl)methyl)-1-methylquinolin-2(1H)-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3,4-dimethoxyphenyl)-4-(4-methoxy-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-5-phenyl-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((cyclohexylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-1-pyridin-2-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | N-{1-[(3E)-4-{5-Cyano-4-[(4-methyl-1H-indol-5-yl)amino]-pyridin-3-yl}but-3-en-1-yl]piperidin-4-yl}benzenesulfonamide | Drug Info |
| FTase --- GTase | CHEMBL1179766 | Drug Info |
| PPAR gamma --- PPAR delta | L-165461 | Drug Info |
| CDK2 --- AuroraA | 8-[(3-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-(2-(dimethylamino)ethyl)piperazin-1-yl)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| H3 --- SERT | 6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| PR --- mRNA of AR | 9-Chloro-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bS,6S,11bR)-6-Methoxymethyl-3a,5b-dimethyl-1,3a,4,5b,6,11b-hexahydro-2H-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,5,8,11-tetraone | Drug Info |
| H3 --- SERT | 4-(4-ethoxyphenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(4-(trifluoromethyl)phenyl)-1-(4-methoxyphenyl)propan-1-one | Drug Info |
| EGFR3 --- HER2 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[(2,2,2-trifluoro-ethyl)-hydrazonomethyl]-pyrimidine-4,6-diamine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 3-(4-bromophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| PR --- mRNA of AR | rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-methyl oxime | Drug Info |
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