Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | [[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-3-sulfonyl)-amino]-acetic acid tert-butyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-phenyl-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(2,3-dihydrobenzo[b]-[1,4]dioxine-6-sulfonamido)3-methylbutyryl)-1,4-diazepan-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3,5-Difluoro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| PR --- mRNA of AR | Hydroxyflutamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-Phenyl-2-[4-(2-p-tolyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-6-fluoro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-chlorophenyl)-3-(4-(trifluoromethyl)phenyl)propan-1-one | Drug Info |
| MMP2 --- MMP9 | 2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one | Drug Info |
| PR --- mRNA of AR | 6-(2-Phenyl-2H-1,4-benzothiazin-3-yl)-2H-1,4-benzoxazin-3(4H)-one | Drug Info |
| MMP2 --- MMP9 | (R)-4-Amino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-butyramide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-3-yl-piperidine-1-carboxamidine | Drug Info |
| PR --- mRNA of AR | 9-Chloro-2,2,4-trimethyl-5-propoxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| MMP3 --- MMP8 | 4-Methoxy-benzenesulfonic acid 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester | Drug Info |
| Ftase --- FPTase | 6-[(2'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| PR --- mRNA of AR | 3a,10-Dimethyl-7-trifluoromethyl-1,2,3a,4,5,10-hexahydro-3H-10,11b-diaza-cyclopenta[a]anthracen-9-one | Drug Info |
| MMP3 --- MMP8 | 2-[4-(4-Dimethylamino-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(3,4,5-trimethoxyphenyl)-1-mtolylpropan-1-one | Drug Info |
| MMP9 --- MMP3 | 2-(1-Hydroxy-2-mercapto-ethyl)-nonanoic acid [(S)-3-methyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-butyl]-amide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Methoxy-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| PR --- mRNA of AR | SID26753134 | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(3-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Hydroxy-phenyl-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Renin --- Cathepsin D | CHEMBL2220375 | Drug Info |
| mTOR --- PI3K delta | 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[6-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid (1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexyl)-amide | Drug Info |
| mTOR --- PI3K gamma | (3-(6-morpholino-9-(1-(4-(pyridin-4-yl)benzyl)piperidin-4-yl)-9H-purin-2-yl)phenyl)methanol | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-trifluoromethyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-1-(naphthalene-1-carbonyl)-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridin-7-one | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(2-chloropyridin-4-yl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}-2-naphthalen-1-yl-benzoylamino)-4-methyl-pentanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| mTOR --- PI3K gamma | (3-(6-morpholino-9-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-9H-purin-2-yl)phenyl)methanol | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid adamantan-1-ylamide | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,3-triazol-1-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | methyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | 5-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-octahydro-quinoline-1-carboxylic acid amide | Drug Info |
| S5AR --- SRD5A2 | (10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-acetaldehyde oxime | Drug Info |
| NET --- SERT | SID49666100 | Drug Info |
| Ftase --- FPTase | 1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-amino}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (4,4'-di-tert-butyl-biphenyl-3-yl)-amide | Drug Info |
| NET --- SERT | (2-Chloro-phenyl)-[(3S,4R)-4-(4-chloro-phenyl)-1-methyl-pyrrolidin-3-yl]-methanone | Drug Info |
| Ftase --- FPTase | 17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114,18.08,12.023,27]hentriaconta-1(27),8,10,14(31),15,17,20(28),21,23,25-decaen-3-one | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cyclopentyl]-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(phenylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-[2-(2-methoxy-phenyl)-1H-indol-3-yl]-acetamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,5-bis-trifluoromethyl-phenyl)-amide | Drug Info |
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