Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 7-allyl-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl}sulfamide | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(5-(4-chlorophenyl)thiophene-2-sulfonamido)-2-methyl-3-phenylcyclopropanecarboxylic acid | Drug Info |
| Erbeta --- ER | 4-{2-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylamino)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-3-methyl-1-(6-trifluoromethyl-1H-benzoimidazol-2-yl)-butyl]-succinamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(2-Chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-tert-butyl-4'-ethynyl-3-methylbiphenyl | Drug Info |
| MMP1 --- MMP3 | (2R)-2-{hexyl[methyl(phenyl)phosphoryl]amino}-N-hydroxypropanamide | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2,5-dipropylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| MMP1 --- MMP8 | (2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-isobutyl-3-[(quinolin-8-ylmethyl)-amino]-succinamide | Drug Info |
| Erbeta --- ER | 2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(4'-(3-(trifluoromethyl)-3H-diazirin-3-yl)biphenyl-4-yl)urea | Drug Info |
| MMP1 --- MMP9 | (R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-2-[(S)-3-methyl-1-(methylcarbamoylmethyl-carbamoyl)-butylamino]-butyric acid | Drug Info |
| Erbeta --- ER | 23-azido-2,3-dehydrosilybin | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4'-(2,2,2-trifluoroethyl)-4-biphenylyl]methanesulfonamide | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-acetic Acid | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-4,7-dimethyl-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| Lck --- VEGFR | N-(2-(3,3-dimethyl-2-oxoazetidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | Drug Info |
| MMP13 --- MMP1 | 1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cyclobutanecarboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-9a-isobutyl-4-methyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| Src --- VEGFR | [6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(1-methyl-1H-indol-4-yl)-amine | Drug Info |
| MMP13 --- MMP1 | 4-(4'-Fluoro-biphenyl-4-sulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | {4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-yl]-phenyl}-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| MMP13 --- MMP1 | (4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-m-tolyl-butyl]-phosphinic acid | Drug Info |
| Erbeta --- ER | 3,8-Dihydroxy-5,11-dioxa-benzo[b]fluoren-10-one | Drug Info |
| VEGFR2 --- BRaf | 3,3-Dimethyl-6-(6-methyl-5-(2-(methylamino)quinazolin-6-yl)isoquinolin-1-ylamino)indolin-2-one | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3-ylmethoxy)-benzenesulfonyl]-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 4-(benzo[d]isoxazol-3-yl)benzene-1,3-diol | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(4-ethylpiperazin-1-yl)ethyl)phenyl)-4-(1H-indol-6-yl)pyrimidin-2-amine | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-4-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | (2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-(5-methyl-2-(prop-1-en-2-yl)hex-4-enyl)chroman-4-one | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-methoxyphenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-2-{[4-(4-diethylamino-but-2-ynyloxy)-benzenesulfonyl]-methyl-amino}-N-hydroxy-3-methyl-benzamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-5-hydroxymethyl-3-(4-hydroxyphenyl)-3H-quinazolin-4-one | Drug Info |
| VEGFR2 --- Ckit | 6,6-Dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- Mcl1 | SID860916 | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyrimidin-5-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-(trifluoromethyl)phenyl)malonamide | Drug Info |
| MMP2 --- MMP13 | 2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-propionamide | Drug Info |
| Ftase --- FPTase | 2-alpha,24,25-trihydroxylanostan-3-one | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2-chlorophenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Bis-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
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