Multi-target agents
Target Pair | Drug Name | |
---|---|---|
Erbeta --- ER | 3-phenyl-4-[4-(2-tetrahydro-1H-1-pyrrolylethoxy)phenyl]-(3S,4R)-3,4-dihydro-2H-7-chromenol | Drug Info |
VEGFR2 --- EGFR3 | 2-Methyl-5-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenol | Drug Info |
JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
Erbeta --- ER | 4-{(Z)-1-[4-(2-Diethylamino-ethoxy)-phenyl]-2-ethyl-hex-1-enyl}-phenol; compound with 4-{(E)-1-[4-(2-diethylamino-ethoxy)-phenyl]-2-ethyl-hex-1-enyl}-phenol | Drug Info |
VEGFR2 --- FGFR1 | N-(4-Benzyloxy-butyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
MEP --- Cathepsin B | 4'-(1-Methyl-piperidin-3-yloxy)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
Erbeta --- ER | 3-(3-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
VEGFR2 --- TEK | (E/Z)-4-(2-(6-phenyl-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
MEP --- Cathepsin B | 4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)-pentanoic acid cyanomethyl-amide | Drug Info |
Erbeta --- ER | 4-{2-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylsulfanyl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
VEGFR2 --- TEK | 3-ethyl-19-methyl-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
MEP --- Cathepsin B | 4'-(1-Methyl-piperidin-4-yloxy)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
Erbeta --- ER | 4-{2-[4-(3-Phenyl-propylamino)-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
VEGFR2 --- TEK | rac-9-cyclopentyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(1,4-dimethylpiperidin-4-yl)thiazol-4-yl)benzamide | Drug Info |
Erbeta --- ER | (S)-9a-ethyl-6-phenyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
VEGFR2 --- TEK | 19-methyl-3-(2-methylpropyl)-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
MEP --- Cathepsin B | [(3,4,5-Trimethoxyphenyl)-(4-methoxy,5-hydroxyphenyl)-ketone]thiosemicarbazone | Drug Info |
Erbeta --- ER | 4,10-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
VEGFR2 --- TEK | 3-(2-(6-aminopyridin-3-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
Met --- VEGFR | N-(3-fluoro-4-(2-(methylthio)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol; hydrochloride | Drug Info |
VEGFR2 --- TEK | SID124349952 | Drug Info |
Met --- VEGFR | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
Erbeta --- ER | 3,7,9-Trihydroxy-5,11-dioxa-benzo[b]fluoren-10-one | Drug Info |
VEGFR2 --- VEGFR1 | N-(4-ethylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
Met --- VEGFR | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide | Drug Info |
Erbeta --- ER | (2-Cyclohexyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
VEGFR2 --- VEGFR1 | N-(2-Bromo-4-chloro-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
MMP1 --- MMP3 | (R)-2-[4-(4-tert-Butyl-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
Erbeta --- ER | [6-Hydroxy-2-(4-isopropyl-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
VEGFR2 --- VEGFR1 | 1-(3-(4-methylpiperazin-1-yl)propyl)-3-(5-(thiophen-3-yl)pyridin-3-yl)-1H-indole | Drug Info |
MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-oxo-1-(2-phenoxy-ethyl)-azepan-3-yl]-succinamide | Drug Info |
Erbeta --- ER | 2-(4-hydroxyphenyl)-3-methyl-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-phenoxyphenyl)benzamide | Drug Info |
MMP1 --- MMP3 | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-5-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-ethylphenyl)acetamide | Drug Info |
Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2H-chromen-7-ol | Drug Info |
VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-4-methyl-benzenesulfonamide | Drug Info |
MMP13 --- MMP1 | 3-Hydroxy-4-[4-(4-methyl-benzyloxy)-benzenesulfonyl]-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
Erbeta --- ER | 7-(bromomethyl)-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
MMP13 --- MMP1 | (S)-N-hydroxy-2,2-dimethyl-4-(4-(pent-4-ynyloxy)phenylsulfonyl)thiomorpholine-3-carboxamide | Drug Info |
Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-methyl-2H-benzo[1,4]oxazine-5,7-diol | Drug Info |
VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
MMP13 --- MMP1 | 4-[4-(4-Fluoro-pyridin-2-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
Erbeta --- ER | CHEMBL365903 | Drug Info |
VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
Pagination
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