Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| FGFR --- PDGFR | 3-Phenyl-3H-benzoimidazol-5-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID93577497 | Drug Info |
| MMP2 --- MMP13 | (R)-2-(6-ethyl-N-isopentylnaphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(naphthalen-2-yloxy)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3,5-difluoro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940308 | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP2 --- MMP13 | (S)-N-(4-fluorobenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-3-yl)-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-3-methyl-2-(4'-(3-methyl-4-(methylamino)benzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)butanoic acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-cyano-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(N-isopropoxy-4'-isopropylbiphenyl-4-ylsulfonamido)-3-methylbutanamide | Drug Info |
| Ftase --- FPTase | 2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-phenyl-propionyl)-piperazin-2-yl]-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-amino-3-oxopropyl)-N-((3-benzyl-7-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide | Drug Info |
| MMP2 --- MMP14 | 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-aminoethyl)-4-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)benzamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyl]-6-(4-propyl-phenyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 1-{4-[3-((2R,3R)-5-tert-Butyl-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-[1,2,4]thiadiazol-5-yl]-piperazin-1-yl}-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2-chloro-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-nitrobenzyl)quinoline-2-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methoxy-biphenyl-4-yl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-3-phenyl-propionylamino)-4-hydroxy-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-amino-5-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxamido]-3-oxa-pentane | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-propyl-phenyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphthalen-1-yl-benzoylamino}-4-methyl-pentanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-amino-2-methylpropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-chlorobenzamide | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-morpholino-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| Ftase --- FPTase | 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-methyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| MMP2 --- MMP9 | 2-{4-[4-(4-cyano-phenyl)-piperazin-1-yl]-benzenesulfonyl}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-p-tolylethynyl-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 4-(amino(1-methyl-1H-imidazol-5-yl)methyl)-2-(3-(3-ethyl-1-methyl-2-oxoazepan-3-yl)phenoxy)benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-Methoxybenzyl)-4-furan-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholinoethyl)-5-(p-tolylethynyl)thiophene-2-sulfonamide | Drug Info |
| Ftase --- FPTase | 6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| DHFR --- VEGFR | 5-[(R/S)-2-(20-Methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| MMP2 --- MMP9 | 3-hydroxy-1-(tosylmethyl)pyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-formyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-5-(cyclohexyloxy)-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| MMP2 --- MMP9 | 5-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-5-[4-(4-methoxy-phenoxy)-phenyl]-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | (+)4-(2-{4-[1-butyl-4-chloro-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1,6-naphthyridin-2(1H)-one | Drug Info |
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