Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-methyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-((5-((benzyl(1-benzyl-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(2-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-methyl-6-morpholino-3-phenyl-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | 2-Amino-3-[3'-(5H-tetrazol-5-yl)-biphenyl-4-ylamino]-propane-1-thiol 8 (FTI-2102) | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethyl)-5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-(3-fluorobenzyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(6-morpholino-4-oxo-1,4-dihydro-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzo[d][1,3]dioxole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-bromobenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N-(2-pyridin-2-ylethyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(2-fluoro-5-trifluoromethyl-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-fluorobenzyl)quinoline-2-carboxamide | Drug Info |
| mTOR --- PI3K gamma | N-[2-(Dimethylamino)ethyl]-4-({[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]-carbamoyl}amino)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | S-[cyclohexyl(diphenyl)methyl]-L-cysteine | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Methoxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Amino-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NET --- SERT | CHEMBL2094106 | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-((R)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2,5-dimethylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| NET --- SERT | 3-(4-Iodo-phenyl)-8-methoxycarbonylmethyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3-fluoro-4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(piperazin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-tert-butylphenyl)diphenylmethylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(2-o-tolyl-1H-indol-3-yl)-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{[3'-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl-4-yl]methyl}sulfamide | Drug Info |
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-4-yl)-1-[4-((S)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(4-(pyrrolidin-1-ylsulfonyl)styryl)nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-((S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-butyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N,N-diethylacrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(tritylthio)propan-1-ol | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-morpholinopropyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| H3 --- SERT | 4-(2-fluorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-((4-(morpholinomethyl)phenyl)ethynyl)pyrimidin-4-amine | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(5-((4-(dimethylamino)piperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)cyclopentanecarboxamide | Drug Info |
| H3 --- SERT | 3-(8-(3,4-dichlorophenyl)-6-methyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)-N,N-diethylpropan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-((5-(pyrrolidin-1-ylmethyl)furan-2-yl)ethynyl)pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 10-(2-Methyl-3-trifluoromethyl-benzyl)-2-morpholin-4-yl-10H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one | Drug Info |
| FGFR --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| H3 --- SERT | 3-(4-chlorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
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