Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-pentanoylamino)-4-hydroxy-butyric acid | Drug Info |
| mTOR --- AKT | trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpteridin-7(8H)-one | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dichlorophenyl)-2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-pyrimido[5',4':5,6]pyrimido[1,2-a]-benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-chloro-benzyl ester | Drug Info |
| mTOR --- PI3K gamma | Methyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| VEGFR2 --- CSrc | 6-(3-(methoxy)phenyl)-2-((4-(4-methyl-1-piperazinyl)phenyl)amino)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| mTOR --- PI3K gamma | (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- FGFR1 | CHEMBL1762529 | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3,5-Difluoro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide | Drug Info |
| VEGFR2 --- FGFR1 | 1-[2-Chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo [3,2-d]pyrimidin-4-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea | Drug Info |
| Ftase --- FPTase | N-sec-Butyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | 19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide | Drug Info |
| NET --- SERT | 2-Methyl-1-(8-methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-1-one | Drug Info |
| VEGFR2 --- TEK | 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Ethylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| NET --- SERT | 3-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarbonyloxy]propyl 4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxylate | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-methylthiophenyl)aminocarbonylamino)-phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-methoxy-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(7-chloro-4-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-{3-ethyl-19-methyl-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(4-methoxyphenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-3-(4-methylpiperazin-1-yl)prop-1-en-1-yl]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(3-(4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl)phenyl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-[1,2,4]triazol-1-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(3-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]urea | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-3-yl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpiperazin-1-yl)methyl)thiophen-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-azido-N-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethyl)-2,3,5,6-tetrafluorobenzamide | Drug Info |
| Ftase --- FPTase | 1-[2-(4-Cyano-phenyl)-2-hydroxy-2-(3-methyl-3H-imidazol-4-yl)-ethyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| CAII --- CAI | 4-Chloro-6-trifluoromethanesulfonylamino-benzene-1,3-disulfonic acid diamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-5-(4-Aminopiperidin-1-yl)pent-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-methylsulfanyl-benzenesulfonamide | Drug Info |
| GSK --- VEGFR | SID124349991 | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-4-(diethylamino)-2-butynamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperidin-1-ylmethyl)furan-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(4-(trifluoromethylthio)phenyl)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(thiophen-3-ylsulfonyl)-1H-indol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | (3-Methoxy-phenyl)-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-yl]-amine | Drug Info |
| H3 --- SERT | N,N-diethyl-3-(6-methyl-8-phenyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-imidazole-2-carboxamide | Drug Info |
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