Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d] isoxazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-methoxy-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | (R)-3-(4-Phenethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(thiophen-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | [(S)-4-[2-(3H-Imidazol-4-yl)-ethyl]-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP3 --- MMP8 | 7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(thiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| MMP3 --- MMP8 | 2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-chloro-6-methoxypyridin-2-yl)-5-isopropoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-butyl]-oxalamide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(4-(diethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-((2R)-1-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanoyl)-octahydro-1H-indole-2-carboxamido)-4-(methylthio)butanoic acid | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-(4-aminobutylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((1-(3-phenoxybenzyl)-1H-imidazol-5-yl)methyl)-1-(4-(trifluoromethyl)phenyl)piperazin-2-one | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- CSrc | CHEMBL214376 | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-N-[4-({4-[(3,4-difluorobenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantan-1-yl-hydroxy-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | SID137275852 | Drug Info |
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(5-phenoxy-pentylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| Ftase --- FPTase | 1-[5-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoate | Drug Info |
| VEGFR2 --- TEK | methyl N-(6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy) benzoxazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (1-hydroxy-pyridin-3-ylmethyl)-amide | Drug Info |
| NET --- SERT | SID533837 | Drug Info |
| VEGFR2 --- TEK | 3-{10-carboximidoyl-5-oxo-14-propyl-4,14-diazapentacyclo[11.7.0.0^{2,6}.0^{7,12}.0^{15,20}]icosa-1(13),2(6),7(12),9,15,17,19-heptaen-18-yl}-1-(4-methylphenyl)urea | Drug Info |
| Ftase --- FPTase | N-Benzyl-N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-methanesulfonamide | Drug Info |
| NET --- SERT | 3-(4-Chloro-phenyl)-2-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| VEGFR2 --- TEK | rac-9-cyclohexyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-2,3-dihydro-1H-indole-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| NET --- SERT | (2R,3S)-3-(2-Hydroxy-4-iodo-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | rac-9-(2-(diethylamino)ethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(3-(3-hydroxypyrrolidin-1-yl)-3-oxoprop-1-enyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(1-benzyl-4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid diphenylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-(5-Bromo-furan-2-ylmethoxymethyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(thiophen-2-yl)urea | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-4-ylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpiperazin-1-ylsulfonyl)methyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | Biphenyl-3-sulfonic acid 2,4-dichloro-benzoylamide | Drug Info |
| FTase --- GTase | 1-methyl-1H-imidazole-4-sulfonic acid {2-[biphenyl-4-yl-(3-methyl-3H-imidazol-4-ylmethyl)amino]ethyl}-(2-methylbenzyl)-amide | Drug Info |
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