Multi-target agents
Target Pair | Drug Name | |
---|---|---|
Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-4-(3-methoxy-propyl)-2,15-dioxo-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
HDAC1 --- HD6 | (S)-benzyl 1-(1H-benzo[d]imidazol-2-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
EGFR3 --- HER2 | SID511952 | Drug Info |
PPAR gamma --- PPAR delta | 2-{4-[2-(1,2,3,4-Tetrahydro-quinolin-7-yloxy)-ethoxy]-benzyl}-malonic acid dimethyl ester | Drug Info |
Renin --- Cathepsin D | (S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-isobutylcarbamoyl-hexyl)-2-(3-methyl-butyrylamino)-succinamic acid | Drug Info |
HDAC1 --- HDAC2 | 4-(3-(4-(Cyclopentyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
EGFR3 --- VEGFR1 | N*6*-Imidazol-1-yl-N*4*-(1H-indol-5-yl)-N*6*-(3-phenyl-propyl)-thieno[3,2-d]pyrimidine-4,6-diamine | Drug Info |
EGFR3 --- VEGFR1 | 2-(2-{4-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethoxy)-ethanol | Drug Info |
PPAR gamma --- PPAR delta | 2-(3-(2-carboxy-4-chlorophenylcarbamoyl)phenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid | Drug Info |
S5AR --- SRD5A2 | (4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (2-chloro-6-trifluoromethyl-phenyl)-amide | Drug Info |
HDAC1 --- HDAC2 | 4-((4-(1H-pyrazol-5-yl)pyrimidin-2-ylamino)methyl)-N-(2-aminophenyl)benzamide | Drug Info |
Erbeta --- ER | 1-{3-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propyl}-pyrrolidine-2,5-dione | Drug Info |
PPAR gamma --- PPAR delta | 5-methyl-2-(3-(4-methyl-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
S5AR --- SRD5A2 | (4aR,6aS)-7-(3,4-Dihydro-2H-quinoline-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
HDAC1 --- HDAC2 | 4-(3-(4-(2-Chlorobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-(10-pentylsulfonyldecyl)-(E)-1-butenyl]phenol | Drug Info |
PPAR gamma --- PPAR delta | 2-(4-(2-(pent-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
S5AR --- SRD5A2 | (4aR,6aR)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
HDAC1 --- HDAC2 | N-hydroxy-7-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)heptanamide | Drug Info |
Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid methyl ester | Drug Info |
PPAR gamma --- PPAR delta | 2-Ethoxy-3-(4-(5-(4-(trifluoromethyl)phenyl)-4-(4-methoxyphenyl)thiazol-2-yl)methoxyphenyl)propanoic Acid | Drug Info |
S5AR --- SRD5A2 | 7-chloro-4a-methyl-3,4,4a,9-tetrahydrophenanthren-2-ylphosphonous acid | Drug Info |
HDAC1 --- HDAC4 | Octanethioic acid S-[(E)-4-((5R,8S,11S)-5-benzyl-8-isopropyl-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraaza-tricyclo[14.2.1.1*2,5*]icosa-1(18),2(20),16(19)-trien-11-yl)-but-3-enyl]ester | Drug Info |
Erbeta --- ER | SID3714271 | Drug Info |
PPAR gamma --- PPAR delta | 2-(3-(6-chloro-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
S5AR --- SRD5A2 | (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
HDAC1 --- HDAC4 | (E)-N-Hydroxy-3-(5-((E)-3-(naphthalen-2-yl)-3-oxoprop-1-enyl)furan-2-yl)acrylamide | Drug Info |
Erbeta --- ER | 4-(furan-2-yl)-7-hydroxy-9a-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
PPAR gamma --- PPAR delta | 3-(4-(3-((4-chloro-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | Drug Info |
S5AR --- SRD5A2 | 3-(17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-propionic acid | Drug Info |
HER2 --- MMP-2 | (2S,3S)-5-(2-(4-aminobutylamino)-2-oxoethyl)-N-hydroxy-2-(3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
Erbeta --- ER | 7-(1,2-Dimethyl-propenyl)-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-ol | Drug Info |
PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-(3-((4-(trifluoromethyl)benzamido)methyl)phenoxy)phenoxy)propanoic acid | Drug Info |
S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid p-tolyl ester | Drug Info |
JAK2 --- CD135 | (16E)-11-(2-(Pyrrolidin-1-yl)ethoxy)-14-(2,2,2-trifluoroethyl)-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]-heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene | Drug Info |
Erbeta --- ER | 1-(4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone | Drug Info |
PPAR gamma --- PPAR delta | 3-(4-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-2-isopropoxypropanoic acid | Drug Info |
ABL --- Src | (2,4-Dichloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-3-chloro-2-fluorophenoxy)propanoic acid | Drug Info |
ABL --- Src | (4-tert-Butoxy-3,5-dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
JNK1 --- JNK3 | 4-methoxy-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)cyclohexanecarboxamide | Drug Info |
Erbeta --- ER | (2S,3R)-2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-3-yl-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-fluorobiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
FGFR --- Src | N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3,3-dimethyl-butyramide | Drug Info |
JNK1 --- JNK3 | methyl 3-(2-(4-(pyridin-4-yl)phenyl)acetamido)thiophene-2-carboxylate | Drug Info |
Erbeta --- ER | 4,4'-(2-phenylethene-1,1-diyl)diphenol | Drug Info |
PPAR gamma --- PPAR delta | (S)-2-methoxy-3-(3-methoxy-4-(3-(4-phenoxyphenoxy)propoxy)phenyl)propanoic acid | Drug Info |
TRIP5 --- mRNA of KIF11 | 2-(trifluoromethyl)-9H-carbazole | Drug Info |
Pagination
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