Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| PR --- mRNA of AR | 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile | Drug Info |
| Erbeta --- ER | 1-[4-(4-Ethyl-3-methyl-piperazin-1-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| PR --- mRNA of AR | 2'-hydroxy-3-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PR --- mRNA of AR | N-{3-[Benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl}-methanesulfonamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethylsulfanyl)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-2-((S)-4-(3-hydroxyphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| PR --- mRNA of AR | (5aS,7S)-3-Methyl-7-(1-(quinolin-6-ylmethylamino)propan-2-yl)-6,7,8,9-tetrahydropyrano[4,3-b]chromen-1(5aH)-one | Drug Info |
| Erbeta --- ER | 2-(4-Isopropyl-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-2-[4-(4-fluoro-phenoxy)-butyl]-N*4*-hydroxy-succinamide | Drug Info |
| PR --- mRNA of AR | 2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitrile | Drug Info |
| Erbeta --- ER | 4-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)-N,N-dimethylbenzenesulfonamide | Drug Info |
| MMP1 --- MMP3 | (S)-3-(4-Fluoro-phenyl)-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide | Drug Info |
| PR --- mRNA of AR | (S)-Bicalutamide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-(thiophen-2-yl)-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MMP1 --- MMP9 | (R)-2-((S)-1-Dimethylcarbamoyl-3-methyl-butylamino)-4-(1,3-dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-butyric acid | Drug Info |
| PR --- mRNA of AR | 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-acrylic acid | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-7-morpholin-4-yl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| PR --- mRNA of AR | Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | (13S,17S)-2-(2-Hydroxy-ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP13 --- MMP1 | 4-(4-Phenoxy-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| Renin --- Cathepsin D | (S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-{(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-[(quinoline-2-carbonyl)-amino]-succinamide | Drug Info |
| Erbeta --- ER | 8-Bromo-7-hydroxy-3-(4-hydroxy-phenyl)-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP1 | 8-bromo-4-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido)-N-hydroxyquinoline-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,4-triazol-1-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-6-(2-hydroxyethyl)-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-propylcarbamoyl-phenyl ester | Drug Info |
| Erbeta --- ER | rac-9a-ethyl-6-methyl-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| MMP13 --- MMP1 | 4-[4-(4-Cyano-phenoxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-methoxycarbonyl-phenyl ester | Drug Info |
| Erbeta --- ER | 2-(3-butoxy-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-thiazol-2-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | 7-((E)-Styryl)-9,10-dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-[6-(Isobutyl-methyl-amino)-4-phenyl-pyridin-2-yl]-phenol | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-2-({4-[4-(3-dimethylamino-propylamino)-but-2-ynyloxy]-benzenesulfonyl}-methyl-amino)-N-hydroxy-3-methyl-benzamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(4'-tert-butyl-4-(trifluoromethyl)biphenyl-2-yl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | (S)-5-[3-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| MMP2 --- HER2 | (1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| S5AR --- SRD5A2 | 6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-bromo-2-(3-fluoro-4-hydroxyphenyl)-7-methoxybenzo[d]oxazol-5-ol | Drug Info |
| MMP2 --- MMP1 | (S)-N-hydroxy-2,2-dimethyl-4-(4-(3,4,5-trimethoxyphenoxy)phenylsulfonyl)thiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-dibenzyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- Mcl1 | SID24840723 | Drug Info |
| MMP2 --- MMP13 | 2-(Biphenyl-4-sulfonylamino)-6-morpholin-4-yl-hex-4-ynoic acid | Drug Info |
| S5AR --- SRD5A2 | ((S)-7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenanthren-2-yl)-phosphinic acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3-hydroxy-phenylethynyl)-benzonitrile | Drug Info |
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