Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| IKKbeta --- JAK2 | (4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(1,1,2-triphenylethylthio)ethanamine | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-propyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-(4-(4-fluorophenoxy)benzylcarbamoyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2,2-dimethylpropan-1-one | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(2-(piperidin-1-yl)ethoxy)-1H-indol-3-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-acetyl-4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{3-[(4-Adamantan-1-yl-benzoylamino)-methyl]-5-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | trans-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-4-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-4-vinylquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-((Piperidin-1-yl)methanone)phenyl)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-4-carboxamide | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-N,N-dimethyl-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-methoxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-benzylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-(Trifluoromethyl)-3,4-dihydro-1H-pyrido[3,2-b]carbazol-2(6H)-one | Drug Info |
| Erbeta --- ER | 6-(4-hydroxy-3-methoxyphenyl)naphthalen-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{1-[3-(4-Benzoyl-2-propyl-phenoxy)-propyl]-1H-indol-5-yloxy}-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(naphthalen-1-yloxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[7-(Trifluoromethyl)-9H-carbazol-2-yl]urea | Drug Info |
| Erbeta --- ER | SID87348867 | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(oxazol-2-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829408 | Drug Info |
| Erbeta --- ER | 4-bromo-7-hydroxy-9a-propyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxyphenyl)-8-methoxy-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-4-carbonitrile | Drug Info |
| JNK1 --- JNK3 | SID103905002 | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-((3R,3aR)-2-acetyl-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-3-yl)-propyl]-4-methyl-[1,4]diazepan-5-one | Drug Info |
| Erbeta --- ER | 2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-4-yl)phenoxy]-N,N-dimethylethanamine | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-4-methyl-1-oxo-1-((S)-3-oxo-1-phenyl-4-(3-phenylpropylthio)butan-2-ylamino)pentan-2-ylcarbamate | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3-(pyridin-4-ylmethyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
| Erbeta --- ER | (4-{4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl}-piperazin-1-yl)-pyridin-4-yl-methanone | Drug Info |
| MEP --- Cathepsin B | [(3-Bromophenyl)-(2,4-ditrifluoromethylphenyl)-ketone]thiosemicarbazone | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID99356130 | Drug Info |
| Erbeta --- ER | 4-Chloro-2-(3-fluoro-4-hydroxy-phenyl)-quinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridin-2-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829416 | Drug Info |
| Erbeta --- ER | 6-hydroxy-2-(4-hydroxyphenyl)quinoline-4-carbonitrile | Drug Info |
| MEP --- Cathepsin B | 2-Amino-6,7-dibenzyloxy-1-(4-methoxyphenyl)-2Hisoquinolin-3-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Erbeta --- ER | 7-allyl-2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MEP --- Cathepsin B | (S)-1-{(S)-2-[((2S,3S)-3-Isobutylcarbamoyl-oxiranecarbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid | Drug Info |
| Lck --- VEGFR | N-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
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