Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP13 | N-Hydroxy-2-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-cyclobutyl}-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (2R,4aS,5R,10bS)-2-((1H-1,2,4-triazol-1-yl)methyl)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| FGFR --- PDGFR | 3-Phenyl-3H-benzoimidazole-5-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-3,3-dimethylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-chlorobenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(N-(3-phenylpropyl)naphthalene-2-sulfonamido)butanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-(morpholine-4-carbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thiophene-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid pyridin-3-ylamide | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-chloro-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N-ethyl-5-(4-hydroxybutyl)-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-(2-methoxy-ethyl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-1-isobutyryl-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829442 | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Bromo-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4-(5-(4-cyanobenzofuran-2-carboxamido)pyridin-2-yl)phenylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | [1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one | Drug Info |
| Ftase --- FPTase | 5-cyano-2-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-N-phenylbenzamide | Drug Info |
| MMP2 --- MMP13 | 1-(4-(4-(hydroxycarbamoyl)tetrahydro-2H-pyran-4-ylsulfonyl)phenyl)-N-methyl-N-(prop-2-ynyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3'-Hydroxyphenyl)-3-methyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(1-oxy-pyridin-4-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methylsulfanyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2,3-dimethoxybenzyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (R)-6-(4-chloro-phenyl)-3-{(S)-2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829249 | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyrazin-2-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP3 | 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid (4'-cyano-biphenyl-4-ylmethyl)-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-methoxyphenylamino)-N-methyl-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-benzenesulfonamide | Drug Info |
| MMP2 --- MMP3 | [4-(3-Ethyl-ureido)-butyl]-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-4-[2-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-piperazine | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-trifluoromethoxy-benzyl ester | Drug Info |
| MMP2 --- MMP9 | N-[2-(1-Hydroxycarbamoyl-ethyl)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda*6*-benzo[f][1,2,5]thiadiazepin-7-yl]-3,5-dimethyl-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-ethyl-4-(3-hydroxyphenyl)-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | (E)-3-Carboxy-2-(16-sulfooxy-hexadecyl)-pent-2-enedioic acid | Drug Info |
| MMP2 --- MMP9 | (S)-2-(1,1-dioxo-1lambda*6*-thiomorpholin-4-yl)-N-hydroxy-3-{methanesulfonyl-[4-(4-trifluoromethyl-phenoxy)-phenyl]-amino}-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3'-amino-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | 3-(4-(5-fluoro-1H-benzo[d]imidazol-2-yl)phenylsulfonyl)-1-hydroxyazepan-2-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(3-hydroxyphenyl)-2-(3-aminobutyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinolin-3-ylmethyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-N,2-dihydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-ethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanamine trihydrochloride | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-cyclohexylmethyl-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | 2-[1,1-Dioxo-7-(4-trifluoromethyl-phenoxy)-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| Lck --- VEGFR | 1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(3-Chloro-4-cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-phenyl-propionic acid | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-7-methoxy-5-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
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