Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-fluoro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-methyl 9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylate | Drug Info |
| Ftase --- FPTase | (S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| MMP2 --- MMP9 | 2-amino-N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-5,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)thiazolidine-4-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(2-tert-butyl-5-(trifluoromethyl)phenyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[(Furan-2-ylmethyl)-amino]-methyl}-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid cyclopropyl ester | Drug Info |
| S5AR --- SRD5A2 | 6-Benzyloxy-5-methoxy-1-methyl-1H-indole-2-carboxylic acid | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-(pyridin-3-yloxy)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-isopropyl-4-phenoxybenzenesulfonamide | Drug Info |
| ABL --- Src | 4-[2-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-hydroxy-propyl]-phenol | Drug Info |
| Ftase --- FPTase | [(S)-4-(3H-Imidazol-4-ylmethyl)-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-(4-Cyanobenzoyl))piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| ABL --- Src | 4-(7-(2-chloro-6-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-cyclopropoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-Hydroxy-phenyl)-5-methyl-pyrimidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2-Chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-3-yl)-propan-1-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-[4-(4-nitro-benzoylamino)-benzenesulfonylamino]-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(7-methyl-9H-carbazol-3-yl)ethanone | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenoxy)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-bromobenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methyl-N-(morpholin-2-ylmethyl)benzamide | Drug Info |
| Ftase --- FPTase | 9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-(3-chloro-phenyl)-6,7-dihydro-5H-pyrido[3,2,1-ij]quinolin-3-one | Drug Info |
| MMP3 --- MMP8 | 2-(4'-Chloro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(2-piperazin-1-yl-ethyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [4-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid ethyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxyphenyl)-N,N,7-trimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | 1-Methyl-1H-pyrazole-4-sulfonic acid benzyl-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide | Drug Info |
| MMP3 --- MMP8 | Oxo-{2-[4-(phenyl-lambda*4*-sulfanyl)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-acetic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | 4-(2-cyclohexyl-1-ethynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-2-(4-hydroxy-phenyl)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(9-(naphthalen-1-yl)-9H-fluoren-9-ylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | (+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1R,8R,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR115135) | Drug Info |
| mTOR --- AKT | N-(6-(6-(4-Methoxyphenylsulfonamido)pyrazin-2-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | N-Benzo[1,3]dioxol-5-yl-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N,N-dimethylbenzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(4-fluorophenyl)-4,7-dihydro-2Hpyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Hydroxy-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829422 | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.