Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PR --- mRNA of AR | rac 2-((4-cyano-3-(trifluoromethyl)phenyl)(2,2,2-trifluoroethyl)amino)-N,N-dimethylacetamide | Drug Info |
| EGFR3 --- HER2 | (R)-1-(2-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-1-yl)ethanone | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (5R,6R)-6-(4-hydroxy-benzoylamino)-octahydro-4,7-methano-inden-5-yl ester | Drug Info |
| HDAC1 --- HD6 | 2-[4-(2-Acetylamino-ethyl)-phenyl]-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| PR --- mRNA of AR | 1,6,8,8,10-Pentamethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| EGFR3 --- HER2 | (R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-indazol-5-ylamino)quinazolin-5-yloxy)propan-1-one | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (2R,3R)-3-(4-hydroxy-benzoylamino)-bicyclo[2.2.1]hept-2-yl ester | Drug Info |
| HDAC1 --- HD6 | (S)-2-(2-phenylacetamido)-N-(4-phenylthiazol-2-yl)-6-(sulfamoylamino)hexanamide | Drug Info |
| PR --- mRNA of AR | (4R,5S)-2,2,4-Trimethyl-5-phenyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzyl-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | (E)-(4-(4-hydroxybenzylidene)-2-(hydroxymethyl)-5-oxotetrahydrofuran-2-yl)methyl 3-isopropyl-4-methylpentanoate | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(benzo[d]thiazol-2-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| Renin --- Cathepsin D | N-[2-(5-Amino-thiophen-3-yl)-1-(1-cyclohexylmethyl-2,4-dihydroxy-hexylcarbamoyl)-ethyl]-2-(morpholine-4-sulfonylamino)-3-phenyl-propionamide | Drug Info |
| EGFR3 --- HER2 | SID506627 | Drug Info |
| PPAR gamma --- 5LOX | (R)-2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid | Drug Info |
| HDAC1 --- HD6 | Descladinose Clarithromycin-N-benzyltriazolylhexahydroxamic Acid | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid (1-cyclohexylmethyl-2,4-dihydroxy-hexyl)-amide | Drug Info |
| EGFR3 --- HER2 | methyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | 2-{5-[3-(3-cyano-7-propyl-1H-indol-6-yloxy)propoxy]-indol-1-yl}ethanoic acid | Drug Info |
| HDAC1 --- HD6 | Octanedioic Acid Hydroxyamide-{3-[1-(4-Hydroxymethylphenyl)-1H-[1,2,3]triazol-4-yl]phenyl}amide | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-10,13-Dimethyl-3-nitro-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid diisopropylamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-2-hexynamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-((2,4-bis(trifluoromethyl)benzamido)methyl)phenoxy)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 5-Benzyloxy-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cyclohexyl]-amide | Drug Info |
| EGFR3 --- VEGFR1 | N*4*-(1H-Indol-5-yl)-N*6*-(2-phenylamino-ethyl)-N*6*-pyrrol-1-yl-thieno[3,2-d]pyrimidine-4,6-diamine | Drug Info |
| PPAR gamma --- PPAR delta | (S,Z)-3-(4-(3-(biphenyl-4-yl)-3-phenylallyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-biphenyl-4-yl-thiazol-2-yl)-heptanoic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | N-phenyl-N-((4aR,4bS,6aS,7S,9aS,9bR,11aR)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl)benzamide | Drug Info |
| Erbeta --- ER | SID14746975 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(6-benzoylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 9-[(1H-indol-6-yl)-amide] 1-methylamide | Drug Info |
| S5AR --- SRD5A2 | 1-(Adamantane-2-carbonyl)-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridin-7-one | Drug Info |
| Erbeta --- ER | (1S,4R,5R)-4-(4-Hydroxy-phenyl)-2,2,6-trimethyl-3-oxa-bicyclo[3.3.1]non-6-en-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(4-(naphthalen-2-yl)thiazol-2-yl)heptanamide | Drug Info |
| S5AR --- SRD5A2 | 2-Chloro-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-oxo-9a-phenyl-2,3,9,9a-tetrahydro-1H-fluorene-4-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(((7-fluorobenzo[d]oxazol-2-yl)(3-phenoxypropyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| HDAC1 --- HDAC4 | Octanethioic acid S-[(E)-4-((8S,11S)-8-isopropyl-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraaza-tricyclo[14.2.1.1(2,5)]icosa-1(18),2(20),4,16(19)-tetraen-11-yl)-but-3-enyl]ester | Drug Info |
| S5AR --- SRD5A2 | sodium-3,3-diisopropyltriaz-1-en-1-olate 2-oxide | Drug Info |
| Erbeta --- ER | 4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(4,4-dimethylcyclohexyl)-2-propylphenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC4 | CHEMBL98345 | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-1-(2,4,6-triisopropylbenzoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Erbeta --- ER | 6-[2-(4-Hydroxy-phenyl)-propyl]-pyridin-3-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[3-(3-phenyl-7-propylbenzo[b]furan-6-yloxy)propoxy]-indol-1-yl}ethanoic acid | Drug Info |
| HER2 --- MMP-2 | (5S,6S)-5-(hydroxycarbamoyl)-6-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid diethylamide | Drug Info |
| Erbeta --- ER | 1-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3H-inden-1-yl]-phenyl}-ethanone | Drug Info |
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