Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-3-yl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| PR --- mRNA of AR | N-(1-Difluoromethoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(4-Acetylpiperazin-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile | Drug Info |
| PR --- mRNA of AR | (5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-morpholinoethoxy)phenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyano-3-fluorophenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide | Drug Info |
| PR --- mRNA of AR | Acetic acid 5-bromo-4-methoxy-2-(5,5,7-trimethyl-spiro[2.5]oct-7-en-4-ylmethyl)-phenyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(methylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4-carboxylic acid | Drug Info |
| PR --- mRNA of AR | 6'-trifluoromethylspiro[cyclohexane-1,2'-(1',2',3',4',8',9'-hexahydropyrido[3,2-g]quinoline)]-8'-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid [6-(4-chloro-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| PR --- mRNA of AR | racemic-5-chloro-6-(1H-indol-3-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-hydroxypiperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| H3 --- SERT | 7-(3-(4-ethylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyano-3-methoxyphenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine | Drug Info |
| PR --- mRNA of AR | 6-(3-chloro-4-fluorophenyl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one | Drug Info |
| EGFR3 --- HER2 | 1-(4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yloxy)ethyl)piperazin-1-yl)ethanone | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645107 | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| Renin --- Cathepsin D | (1S,5S)-7-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(4-Chlorophenylsulfonyl)-2-(4-fluorophenyl)acetamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 3-(3-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| S5AR --- SRD5A2 | Bexlosteride | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-aminopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| HD6 --- HDAC4 | 2,2,2-trifluoro-1-(5-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid phenyl ester | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(3-(morpholinomethyl)phenyl)pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-(4-hydroxy-benzyl)-cyclopentyl ester | Drug Info |
| HDAC1 --- HD6 | 1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)-2,2,2-trifluoroethanone | Drug Info |
| S5AR --- SRD5A2 | 17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,6-dione | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(1-methyl-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PKCA --- NPKC delta | 3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-[4-(N-4-methoxy-phenyl-N-methyl-sulfamoyl)-phenyl]-2-oxoethyl trithiocarbonate | Drug Info |
| S5AR --- SRD5A2 | (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-4-fluoro-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(quinolin-4-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PKCA --- NPKC delta | 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-isobutyl-5-methyl-hex-(E)-ylidene]-5-thioxo-tetrahydro-furan-2-ylmethyl ester | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)-N-hydroxyhexanamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid p-tolylamide | Drug Info |
| EGFR3 --- HER2 | {6-[2-(2-Methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-amine | Drug Info |
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