Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(3-fluoroazetidin-1-yl)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylpropylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-hydroxy-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-[2-(3H-imidazol-4-yl)-ethyl]-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(2'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-((2R,4aS,5R,10bS)-2-((methylamino)methyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol | Drug Info |
| Ftase --- FPTase | 7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-3-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(cyclobutanecarbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4'-(trifluoromethyl)-4-biphenylyl]methanesulfonamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-(2,2,2-trifluoro-ethyl)-benzyl ester | Drug Info |
| MMP2 --- MMP9 | methyl 4-(3-(N-hydroxyformamido)-4-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butyl)benzoate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-Ethyl 1-(3-hydroxyphenyl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Cyclopropyl-10-methoxy-8-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(isopropylamino)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-(3-hydroxyphenyl)-N,N-dimethyl-2,3,6,7-tetrahydrofuro[3,2-h]isoquinoline-8(9H)-carboxamide | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-cyclopropylmethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 6-Benzyloxy-2-(2,5-dichloro-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-chlorobenzamide | Drug Info |
| Ftase --- FPTase | methyl 10-cyano-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaene-4-carboxylate | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| Src --- VEGFR | CHEMBL425209 | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-phenethyl-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-[4-(2-Bromo-ethyl)-piperazin-1-yl]-5-[4-(4-bromo-phenoxy)-phenyl]-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-5-[4-(4-iodo-phenoxy)-phenyl]-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- AuroraA | 4-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[((E)-2-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- CD135 | (Z)-(5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl}-2,4-dimethyl-1H-pyrrol-3-yl)acetic acid | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(2-methoxy-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-1-(1-Methyl-1H-imidazole-4-sulfonyl)-piperidine-3,4-dicarboxylic acid 3-hydroxyamide 4-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide} | Drug Info |
| VEGFR2 --- CDK1 | N-((5-(3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)methyl)propan-1-amine | Drug Info |
| Ftase --- FPTase | (S)-2-(4-((R)-2-amino-3-mercaptopropylamino)benzamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- CDK2 | 1-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-6,7-dihydro-2H-pyrano[3,4-c]pyrrol-4-one | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)benzamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(furan-3-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Benzoyl-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(Hexadecane-1-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-1,2,4-triazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP3 --- MMP8 | 2-(5-Dimethylamino-naphthalene-1-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 1-(3-fluoro-4-(2-(furan-2-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| MMP3 --- MMP8 | [2-(4-Methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-3-cyclopentylpropanamide | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.