Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | 2-(5-chloro-2-(4-methoxyphenoxy)pyridin-4-ylamino)-N-methylbenzamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid o-tolylamide | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | (R)-2-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)-2-phenyl-1H-indol-3-yl)-N-(4-(4-hydroxyphenyl)butan-2-yl)acetamide | Drug Info |
| S5AR --- SRD5A2 | 8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| JNK1 --- JNK3 | 4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid | Drug Info |
| Erbeta --- ER | broussonin A | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-10,13-Dimethyl-3-oxo-4-trifluoromethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid tert-butylamide | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-dichlorophenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 3-(5-bromo-6-hydroxynaphthalen-2-yl)benzo[d]isoxazol-6-ol | Drug Info |
| ABL --- Src | 4-(2-Bromo-4-chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[2,5-Dioxo-1-(3-phenyl-propyl)-piperidin-4-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester | Drug Info |
| Erbeta --- ER | 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| ABL --- Src | 4-(2-Bromo-3,4,5-trimethoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| MEP --- Cathepsin B | 2-(p-tolyl(3-(trifluoromethyl)phenyl)methylene)hydrazinecarbothioamide | Drug Info |
| Erbeta --- ER | (2-Cyclopentyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| FGFR --- Src | 1-Phenyl-1H-benzoimidazole-4,5-diol | Drug Info |
| MEP --- Cathepsin B | 2-tert-Butyloxycarbonylamino-6,7-methylenedioxy-1-(4-methoxyphenyl)-2H-isoquinolin-3-one | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(R)-8-chloro-3-(3-morpholin-4-yl-propyl)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | 2-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-1-phenyl-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4'-(trifluoromethyl)-3-biphenylyl]methanesulfonamide | Drug Info |
| Met --- VEGFR | (S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | 3,8-dihydroxy-1,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(6-benzyl-3-methyl-7-oxo-6,7-dihydroisothiazolo[4,5-d]pyrimidin-5-yl)propyl)-4-methylbenzamide | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide | Drug Info |
| Erbeta --- ER | 5-[4-(2-dimethylamino-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{4'-[(trifluoromethyl)thio]-4-biphenyl}urea | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Chloro-4H-thieno[3,2-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Erbeta --- ER | 2-Phenyl-1-thiophen-2-yl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-Dimethylenastron | Drug Info |
| MMP1 --- MMP3 | (4-Benzyloxycarbonylamino-butyl)-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| Erbeta --- ER | N-(3-hydroxy-4,7-dimethyl-6-oxo-6H-benzo[c]chromen-8-yl)methanesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP1 --- MMP3 | Phosphinic acid derivative | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-3,3-dimethyl-butan-2-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-trifluoromethyl-biphenyl-4-ylamine | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-4-dimethylamino-benzamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-thiophen-2-yl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-isonicotinamide | Drug Info |
| Erbeta --- ER | 3-(4-(3-butyl-6-hydroxy-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-dimethyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| MMP13 --- MMP1 | 9-(4-But-2-ynyloxy-benzenesulfonyl)-6-thia-9-aza-spiro[4.5]decane-10-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 1-Isopropyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-8-fluoro-3-(3-hydroxy-propyl)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| MMP13 --- MMP1 | 4-{(R)-Carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic Acid Propyl Ester | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(3-Hydroxy-phenyl)-2-{4-[2-(4-methyl-piperidin-1-yl)-ethoxy]-phenyl}-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
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