Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | [3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Chloro-biphenyl-4-sulfonyl)-6-nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| MMP3 --- MMP8 | 2-[3-(2-Hydroxy-benzoylamino)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | (S)-N-(3-fluoro-4-(2-(4-((N-(1-methoxypropan-2-yl)acetamido)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-4-methylsulfanyl-butan-1-one | Drug Info |
| MMP3 --- MMP8 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl-biphenyl-4-sulfonylamino)-propyl]-phosphonic acid | Drug Info |
| VEGFR2 --- CSrc | CHEMBL198752 | Drug Info |
| Ftase --- FPTase | 4-[(5-chloro-3'-methoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-{(S)-1-((S)-1-phenyl-ethylcarbamoyl)-2-[4-(3-phenyl-ureido)-phenyl]-ethyl}-oxalamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-chloro-6-methoxypyridin-2-yl)-5-isopropoxy-7-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-isopropyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| mTOR --- AKT | N-(5-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | CHEMBL198701 | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 2-(Biphenyl-4-yloxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(3-(4-methylpiperazin-1-yl)propyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methoxybenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)-quinazolin-6-yl]but-2-enamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-pyridazin-4-ylurea | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-{3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}urea | Drug Info |
| Ftase --- FPTase | (R)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-methyl]-benzoylamino}-3-methylsulfanyl-propionic acid | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-hydroxyethyl)phenyl)urea | Drug Info |
| VEGFR2 --- TEK | rac-9-isopropyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | N-Benzo[1,3]dioxol-5-ylmethyl-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NET --- SERT | 2-(1-Ethyl-6-methyl-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| VEGFR2 --- TEK | propyl N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}carbamate | Drug Info |
| Ftase --- FPTase | 1-{4-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-cyclohexyl}-ethanone | Drug Info |
| NET --- SERT | 1-(4-Chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propylamine | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-1-oxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-3-yl)-ethanone | Drug Info |
| NET --- SERT | 2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(3,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | (S)-N-(2-(3-aminopiperidin-1-yl)-5-(trifluoromethyl)phenyl)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluorobenzamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-2-ylmethyl-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(2-chloro-5-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-3-isopropylbenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{(4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino}-3-phenyl-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(6-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | SID124349827 | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-4-methyl-pentanoylamino}-3-hydroxy-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(2-(2-(pyrrolidin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 6-Pyridin-4-yl-3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidine | Drug Info |
| FTase --- GTase | (E)-N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-phenyl-acrylamide | Drug Info |
| CDK1 --- CDK2 | 4-(5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)benzenesulfonamide | Drug Info |
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