Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MEP --- Cathepsin B | [(S)-1-(2,5-Dioxo-1-phenethyl-piperidin-4-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Erbeta --- ER | 2-(trifluoroacetyl)-tetrahydro-6-isoquinolinol | Drug Info |
| MEP --- Cathepsin B | 9-(3-hydroxypropyl)-6-(3-(thiophen-2-yl)benzylamino)-9H-purine-2-carbonitrile | Drug Info |
| Erbeta --- ER | 10-[4-(2-Piperidin-1-yl-ethoxy)-benzyl]-10H-benzo[4,5]thieno[3,2-b]indol-7-ol | Drug Info |
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| Erbeta --- ER | (2S,3S)-5-Fluoro-7-hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-1-yl)propyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Erbeta --- ER | 4,9-dichloro-3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| MMP1 --- MMP3 | [(S)-3-((R)-2-Hydroxycarbamoylmethyl-decanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester | Drug Info |
| Erbeta --- ER | 3-epicycloeucalenol | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-oxo-1-(3-phenoxy-propyl)-azepan-3-yl]-succinamide | Drug Info |
| Erbeta --- ER | 2-(6-hydroxynaphthalen-2-yl)benzo[d]oxazol-6-ol | Drug Info |
| MMP1 --- MMP3 | 2-[(S)-1-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pentanoylamino)-3-methyl-butyl]-3H-benzoimidazole-5-carboxylic acid methyl ester | Drug Info |
| Erbeta --- ER | 1-cyclopropylmethyl-3-(4-hydroxy-phenyl)-1,2,3,4-tetrahydro-quinolin-7-ol | Drug Info |
| MMP1 --- MMP9 | 11-Isobutyl-3-methyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 8-dimethylcarbamoylmethyl-amide 12-hydroxyamide | Drug Info |
| Erbeta --- ER | SID29215034 | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| MMP13 --- MMP1 | 1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-8-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxamide | Drug Info |
| Erbeta --- ER | 4-{8-Methoxy-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-4-yl}-phenol | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-((1S,5R)-5-hydroxy-2,2,5-trimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-5-carboxamide | Drug Info |
| Erbeta --- ER | (S)-6-chloro-9a-ethyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PR --- mRNA of AR | 5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-cyclohexylmethyl)-phenol | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-(2-methoxy-acetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-4,9a-dimethyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-phenylpropan-1-one | Drug Info |
| MMP13 --- MMP1 | 1-(4-Methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | Anthraflavic acid | Drug Info |
| PR --- mRNA of AR | (R)-3-(4-Hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)-propanamide | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | [4-(2-Benzyl-1-phenyl-but-1-enyl)-phenoxymethyl]-dimethyl-amine | Drug Info |
| PR --- mRNA of AR | 8-Ethyl-8-methyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| MMP13 --- MMP14 | 4-{4-[5-Amino-3-(2-ethoxy-ethyl)-2,4,6-trioxo-piperidin-3-yloxy]-phenoxy}-N-methyl-benzamide | Drug Info |
| Erbeta --- ER | 4-[6-(Methyl-phenethyl-amino)-4-o-tolyl-pyridin-2-yl]-phenol | Drug Info |
| PR --- mRNA of AR | N-(3-Dibenzylamino-2-methyl-phenyl)-methanesulfonamide | Drug Info |
| MMP13 --- MMP8 | 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol | Drug Info |
| Erbeta --- ER | 4-(4-Hydroxyphenyl)-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-8-ol | Drug Info |
| PR --- mRNA of AR | 3-[(4-methoxyphenyl)phenylmethyl]indole | Drug Info |
| MMP2 --- HER2 | (6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino[1,2-a]indol-2(1H)-ylcarbonyl)-5-azaspiro[2.5]octane-7-carboxamide | Drug Info |
| Erbeta --- ER | 4-(5-hydroxybenzo[d]isoxazol-3-yl)benzene-1,3-diol | Drug Info |
| PR --- mRNA of AR | 8-Chloro-6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| Erbeta --- Mcl1 | 3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4H-chromen-4-one | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-2,15-dioxo-4-phenyl-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(4-Benzyloxy-5-ethyl-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-acetylamino-phenyl ester | Drug Info |
| MMP2 --- MMP13 | (R)-2-(N-(2-(dimethylamino)ethyl)naphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
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