Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP3 | 4-Benzyloxy-N-hydroxy-3-(4-methoxy-benzenesulfonyl)-butyramide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2-hydroxyethanone | Drug Info |
| Ftase --- FPTase | 2-(3-Benzyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-phenethyl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP3 | {(S)-2-[(S)-2-Cyclohexyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-ethylcarbamoyl]-5-phenyl-pentyl}-phosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-2-(p-aminobenzoyl)-6-methyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-5-Benzyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-(pyridin-4-ylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-acetoxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethylester | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-((S)-4-methyl-2-{(S)-3-methyl-2-[(E)-7,11,15-trimethyl-4-(phosphonomethyl-carbamoyl)-hexadeca-6,10,14-trienoylamino]-butyrylamino}-pentanoylamino)-propionic acid | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(2-trifluoromethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-amine | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-3-Methyl-2-(2-phenylmethanesulfinyl-acetylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | {5-[7-(3,5-Dimethoxy-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-5-hydroxycarbamoyl-pentyl}-carbamic acid tert-butyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone | Drug Info |
| Ftase --- FPTase | (S)-4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(pyridin-3-ylmethyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | 1-((4-(4-chlorophenoxy)phenylsulfonyl)methyl)-3-hydroxypyridin-2(1H)-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5-bromo-6-chloro-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-N-{1-(1-methyl-1H-indol-2-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4'-bromo-3,3'-difluoro-4-biphenylyl)urea | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(piperidin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| HER2 --- VEGFR | 6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-3-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[4-(3-methoxy-phenylethynyl)-phenylsulfanyl]-butyric acid | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxypyridin-3-yl)-7-(3-morpholinopropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | (R)-3-Phosphono-2-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienoylamino)-propionic acid | Drug Info |
| MMP2 --- MMP9 | 2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid | Drug Info |
| VEGFR1 --- FGFR1 | 2-(4-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | N-Isopropyl-N-(1-methyl-1H-pyrazol-3-ylmethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- Beta PDGFR | 9-Chloro-2-({3-[3-(dimethylamino)propyl]-4-methoxyphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]-benzazepine-6-thione | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methyl-benzyl ester | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-(4-methylpiperazin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(1H-indol-5-yl)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-6-[4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(3-(2-morpholinoethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(butyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (2S)-2,6-diamino-N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)hexanamide | Drug Info |
| VEGFR2 --- Ckit | 1-cyclohexyl-3-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea | Drug Info |
| Ftase --- FPTase | (4-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| MMP3 --- MMP8 | 2-Benzenesulfonyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamoyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 15,16-dibenzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP3 --- MMP8 | (S)-N-[3-Hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-3-phenylacetylamino-succinamic acid tert-butyl ester | Drug Info |
| VEGFR2 --- Cmet | 3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluoro-N-phenylbutanamide | Drug Info |
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