Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| S5AR --- SRD5A2 | (7aS,8R)-7a-Methyl-2-oxo-2,3,4,7,7a,8,9,10,10a,10b,11,12-dodecahydro-indeno[4,5-c]quinolizine-8-carboxylic acid tert-butylamide | Drug Info |
| Erbeta --- ER | geldanamycin-estradiol hybrid | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-methoxyphenyl)acetamide | Drug Info |
| S5AR --- SRD5A2 | 1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-one | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-pyridin-3-ylmethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MMP13 --- MMP1 | 3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2-tert-butyl-5-chloro-phenyl)-amide | Drug Info |
| Erbeta --- ER | (S)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | Drug Info |
| MMP13 --- MMP1 | 1-(4-Methoxy-benzenesulfonylamino)-cyclopentanecarboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,10R)-7-(1,5-Dimethyl-hexyl)-1,4a,6a,10-tetramethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-phenyl-pyrrolo[2,1,5-cd]indolizin-5-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-6-(2-(diethylamino)ethyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | SID144206545 | Drug Info |
| Erbeta --- ER | 5'-(2-hexahydro-1-pyridinylethoxy)-2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
| MMP13 --- MMP1 | 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3,5-dimethyl-benzamide | Drug Info |
| ABL --- Src | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3aS,4R,9bR)-4-(4-hydroxyphenyl)-2-(trifluoromethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| MMP13 --- MMP1 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-3-methylbutanamide | Drug Info |
| ABL --- Src | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(2-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(2H-pyrazol-3-yl)-phenoxy]-phenoxy}-piperidine-2,4,6-trione | Drug Info |
| FGFR --- Src | 6-(2,6-Dichloro-phenyl)-N*2*-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine | Drug Info |
| Erbeta --- ER | 4-[4-Phenyl-6-(propyl-pyridin-2-ylmethyl-amino)-pyridin-2-yl]-phenol | Drug Info |
| MMP13 --- MMP9 | 1-butyl-N-hydroxy-4-(4-methoxyphenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | Drug Info |
| Erbeta --- ER | SID57262455 | Drug Info |
| MMP2 --- MMP1 | trans-2-hydroxycyclopentyl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Erbeta --- Mcl1 | 2,3-di(furan-2-yl)quinoxaline | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(2,5-dimethylthiazol-4-ylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3'-nitro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| FGFR --- PDGFR | 5-Methoxy-1-thiophen-2-yl-1H-benzoimidazole | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(3,5-dimethylpiperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID24831583 | Drug Info |
| Ftase --- FPTase | 7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1-methyl-1,5-dihydro-benzo[e][1,4]oxazepin-2-one | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-[3-(4-trifluoromethyl-phenoxy)-pyrrolidine-1-sulfonyl]-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-benzyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3,5-Difluoro-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(1-methyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-fluoro-2-methyl-9H-carbazole | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-phenylamino-phenoxy)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-({3-[(4-methoxybenzoyl)amino]pyrrolidin-1-yl}sulfonyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-2-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | 1-acetyl-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-(methoxy)-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | 4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid (3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP14 | N-((2S,4S)-1-(4-(2,5-dimethylphenethyl)piperidin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl)-N-hydroxyformamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-isobutyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 3-methyl-benzyl ester | Drug Info |
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