Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PR --- mRNA of AR | 5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Ftase --- FPTase | 3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-methyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4'-chloro-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)biphenyl-4-sulfonamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-p-tolylpropan-1-one | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(aminomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| MMP2 --- MMP9 | 2-(4-(2,4,6-Trioxo-5-(4-phenoxyphenyl)hexanhydropyrimidin-5-yl)-1,4-diazepane-1-carbonyl)benzylbenzoate | Drug Info |
| PR --- mRNA of AR | 1-Ethyl-6,8,8-trimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| MMP2 --- MMP9 | 2-[1,1-Dioxo-7-(4-trifluoromethyl-phenoxy)-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| PR --- mRNA of AR | 1,6,8,8-Tetramethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(3-Chloro-4-cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-phenyl-propionic acid | Drug Info |
| PR --- mRNA of AR | 2,2,4-trimethyl-6-(5-nitrothiophen-2-yl)-1,2-dihydroquinoline | Drug Info |
| Ftase --- FPTase | 5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)-2-(methylsulfonyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-3-(quinolin-8-ylsulfonyl)thiazolidine-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 5-(4-(1-(hydroxyimino)-2,2-dimethylpropyl)phenyl)-1-methyl-1H-pyrrole-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphenyl-3-carboxylic acid 37 (FTI-2317) | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-nitro-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-phenyl-1-p-tolylpropan-1-one | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)-N-hydroxyformamide | Drug Info |
| Renin --- Cathepsin D | (S)-4-(2-amino-6-phenoxyquinazolin-3(4H)-yl)-N,4-dicyclohexyl-N-methylbutanamide | Drug Info |
| Ftase --- FPTase | Acetic acid 2-acetoxy-6-(3-acetoxy-2,5-diformyl-benzoyl)-phenyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-2-(cis-2,6-dimethylmorpholino)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | 1-{4-[4,5-Dihydroxy-6-hydroxymethyl-3,4,5,6-tetramethyl-3-(3,4,5-trihydroxy-2,4,5,6,6-pentamethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2,6-dihydroxy-phenyl}-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-chloro-3-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-iodo-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-hydroxy-phenyl)-amide | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-((E)-2-phenyl-ethenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-2-yl ester | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Chloro-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-diethyl-5-isopropyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| MMP3 --- MMP8 | 2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-6-bromo-9a,11a-dimethyl-1-(3-methylbutanoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-butyl]-oxalamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,7R)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Ftase --- FPTase | (S)-2-((2R)-1-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanoyl)-octahydro-1H-indole-2-carboxamido)-4-(methylthio)butanoic acid | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid biphenyl-4-ylamide | Drug Info |
| Ftase --- FPTase | 4-((1-(3-phenoxybenzyl)-1H-imidazol-5-yl)methyl)-1-(4-(trifluoromethyl)phenyl)piperazin-2-one | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| S5AR --- SRD5A2 | (R)-3-{(2S,3S)-3-[2-(2,6-Diethyl-phenoxy)-acetylamino]-2-hydroxy-4-phenyl-butyryl}-thiazolidine-4-carboxylic acid tert-butylamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine | Drug Info |
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