Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methylbenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(phenylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-[2-(2-methoxy-phenyl)-1H-indol-3-yl]-acetamide | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[4-morpholin-4-yl-3-(trifluoromethyl)phenyl]urea | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-(6-(morpholinomethyl)pyridin-2-yl)vinyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 2-[1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-sulfonyl]-benzoic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3,4-dimethoxyphenyl)-4-(6-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | pentapotassium ({[(6E,10E,15E,19E)-2,6,10,16,20,24-hexamethyl-13-phosphonatopentacosa-2,6,10,15,19,23-hexaen-13-yl]phosphinato}methyl)phosphonate | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-(pyrrolidine-1-carbonyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({(4-Cyano-benzyl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-fluoro-4-sulfamoyl-phenyl)-acetamide | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(ethoxyimino)-2-methylpropyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperazin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-nitrophenoxy)-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(trifluoromethoxy)quinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| VEGFR2 --- TEK | 1-[4-(dimethylamino)phenyl]-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-(2-(dimethylamino)ethyl)-N-methylacrylamide | Drug Info |
| H3 --- SERT | 1-(4-ethylphenyl)-3-methyl-6-(4-(4-(1-phenylvinyl)cyclohexyl)butyl)-1,2,3,4-tetrahydronaphthalene | Drug Info |
| EGFR3 --- HER2 | 1-(5-Bromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| VEGFR2 --- TEK | N-(3-(2-aminoquinazolin-6-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzenesulfonyl-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | (5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(4-benzylamino-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 7-(3-(3,3-difluoropyrrolidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-{6-[5-(1-oxo-1lambda*4*-thiomorpholin-4-ylmethyl)-furan-2-yl]-quinazolin-4-yl}-amine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(3-(2-(pyridin-4-yl)ethyl)pyridin-4-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-imidazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| HDAC --- VEGFR | N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)pyridine-2,5-dicarboxamide | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dichloro-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylthiourea | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-5-(pyridin-4-ylmethylamino)-N-(quinolin-3-yl)isoxazole-4-carboxamide | Drug Info |
| PKCA --- NPKC delta | N1-(3-(pyridin-4-yl)-2,6-naphthyridin-1-yl)ethane-1,2-diamine | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-[3-(2-phenoxy-ethylcarbamoyl)-phenyl]-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2,4-difluoro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| VEGFR2 --- VEGFR1 | [4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 1-methyl-piperidin-4-yl ester | Drug Info |
| PKCA --- NPKC delta | 4-(2-Ethoxycarbonyl-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-(4-bromophenyl)acrylate | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-N-(3-methyl-4-(trifluoromethyl)phenyl)-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (2R,3R)-3-(4-hydroxy-benzoylamino)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester | Drug Info |
| HDAC1 --- HD6 | 2-(3-Benzenesulfonylamino-phenyl)-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | tyrphostin AG-825 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chlorophenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.