Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP3 --- MMP8 | Oxo-{2-[4-(phenyl-lambda*4*-sulfanyl)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-benzyl-7-(6,7-dimethoxyquinolin-4-yloxy)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(2-cyclohexyl-1-ethynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-2-(4-hydroxy-phenyl)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3-(methoxy)-4-(4-methyl-1-piperazinyl)phenyl)-amino)pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | (+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1R,8R,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR115135) | Drug Info |
| mTOR --- AKT | N-(6-(6-(4-Methoxyphenylsulfonamido)pyrazin-2-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | 2,6-dimethylphenyl (2,5-bis(methyloxy)phenyl)methyl(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)carbamate | Drug Info |
| Ftase --- FPTase | N-Benzo[1,3]dioxol-5-yl-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N,N-dimethylbenzamide | Drug Info |
| VEGFR2 --- CSrc | Benzo[1,3]dioxol-4-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Hydroxy-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-{7-ethoxy-4-[(4-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)amino]quinazolin-6-yl}but-2-enamide | Drug Info |
| Ftase --- FPTase | 6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-phenyl]-3-{4-[(4-methylpiperazine-1-yl)carbonyl]phenyl}urea Hydrochloride | Drug Info |
| VEGFR2 --- FGFR1 | N2-(3,5-dimorpholinophenyl)-N4-methyl-N4-m-tolylpyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-cyclohexylmethyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(1-((6-morpholinopyridin-3-yl)methyl)piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Acetyl-benzyl-amino)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 2-((5-bromo-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | CHEMBL499864 | Drug Info |
| Ftase --- FPTase | 1-[4-(2-Bromo-8-chloro-11H-10-oxa-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| NET --- SERT | 8-Cyclopropylmethyl-3-(4-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | 5-(4-(dimethylamino)phenyl)-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxymethyl-biphenyl-3-carbonitrile | Drug Info |
| NET --- SERT | 2-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2,5-difluorophenyl)aminocarbonylamino)-phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 3-vGGPP | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-(5-(piperidin-1-ylmethyl)pyridin-2-yl)vinyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-{3-butyl-19-methyl-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(4-methoxyphenyl)urea | Drug Info |
| Ftase --- FPTase | 11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-methoxycarboxamide (RPR113401) | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 1-[1-[(Z)-ethylidene]-5,9-dimethyl-(4E)-4,8-decadienyl]benzene1-diphosphate (3-phFPP) | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-4-morpholin-4-ylbut-1-en-1-yl]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(2-methylpropyl)-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(benzo[b]thiophen-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-1-methyl-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 19-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3,4-dimethoxyphenyl)-4-(4-fluoro-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-4-ylmethyl)-2-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-thiomorpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-{[4-methoxy-phenylimino]-methyl}-pyrimidine-4,6-diamine | Drug Info |
| PDE --- TNF alpha | (R)-Rolipram | Drug Info |
| VEGFR2 --- VEGFR1 | GW627834A | Drug Info |
| H3 --- SERT | 7-(3-(4-isopropylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
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