Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-chloro-benzyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | (5-(3-aminopropyl)-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)(azetidin-1-yl)methanone | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-(pyridin-3-yl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-phenyl-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Lck --- VEGFR | N-(4-chloro-2-methyl-3-(trifluoromethyl)phenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | Drug Info |
| mTOR --- PI3K gamma | (S)-1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclopentylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Src --- VEGFR | CHEMBL386996 | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)ureido)benzamide | Drug Info |
| Ftase --- FPTase | 2-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-9-(3-chloro-phenyl)-5-methyl-5,9-dihydro-8-thia-5-aza-benzocyclohepten-6-one | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| mTOR --- PI3K gamma | isopropyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-methyl-piperidin-4-yl ester | Drug Info |
| VEGFR2 --- Beta PDGFR | (Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | Drug Info |
| NET --- SERT | SID533836 | Drug Info |
| Ftase --- FPTase | 2-[1-(3-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(4-methoxyphenyl)pyrimidine-5-carbonitrile | Drug Info |
| NET --- SERT | 1-[3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-hydroxy-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 1-(5-(3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N,N-dimethylmethanamine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(piperidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| VEGFR2 --- Ckit | N3-(2-aminopyrimidin-5-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)acrylamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| VEGFR2 --- Cmet | 1-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-benzyl-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- Cmet | SID174006531 | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxy-pyridin-3-ylmethyl ester | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(4-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| FTase --- GTase | 5-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyloxy)methyl)-1H-imidazol-1-yl)methyl)picolinonitrile | Drug Info |
| VEGFR2 --- CSrc | 4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-[(4-morpholin-4-ylphenyl)amino]-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((diethylamino)methyl)furan-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| H3 --- SERT | 3-(4-(1-isopropylpiperidin-4-yloxy)phenyl)-N,N-dimethyl-3-phenoxypropan-1-amine | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-(trans-4-aminocyclohexylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| EGFR3 --- HER2 | N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine | Drug Info |
| PI3K gamma --- PI3K delta | henicosa-4,7,10,12,15,18-hexaenoic acid | Drug Info |
| H3 --- SERT | 7-((1-isopropylpiperidin-4-yl)methoxy)-4-(4-methoxyphenyl)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| VEGFR2 --- CSrc | 4-methyl-3-(1-(6-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-m-tolylbenzamide | Drug Info |
| EGFR3 --- HER2 | 6-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyhexanamide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| VEGFR2 --- EGFR3 | 5-(5,6-Dimethyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2-methyl-phenol | Drug Info |
| EGFR3 --- HER2 | 2-(2-(4-Hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(4-(thiazol-2-yl)piperazin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
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