Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-5-(hydroxymethyl)-N-methyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzo[1,3]dioxol-5-ylmethyl ester | Drug Info |
| MMP2 --- MMP13 | 2-[4-(4-Bromo-benzoylamino)-benzenesulfonylamino]-6-morpholin-4-yl-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(2-fluoro-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-methoxy-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP13 | 1-(3,4-dichlorobenzyl)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-Trifluoromethyl-9H-delta-carboline | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-propan-1-one | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(piperidin-1-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(thiophen-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | SID405162 | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-{4-[3'-(2-methoxy-ethoxy)-2-methyl-biphenyl-4-yl]-piperidine-1-sulfonyl}-2-methyl-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-phenyl]sulfamide | Drug Info |
| Ftase --- FPTase | (1R,8R,9S,13S)-11-[2-(2-methoxyphenyl)prop-2-enoyl]-1-(4-methylphenyl)-11-azatetracyclo[6.5.2.0^{2,7}.0^{9,13}]pentadeca-2,4,6-triene-9-carboxylic acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-(4-morpholinobutylamino)-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methyl-N-(piperidin-4-ylmethyl)benzamide | Drug Info |
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid cyclohexylmethyl-amide | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-4-(2-methoxy-phenyl)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(5-chloro-2-fluoro-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-((R)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(2,4-dimethylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-{(S)-2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-6-phenyl-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (5-(3-aminopropyl)-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)(pyrrolidin-1-yl)methanone | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-(2-methoxy-ethyl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP8 | N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(4-(3-(5-oxa-2-aza-bicyclo[2.2.1]heptan-2-yl)propyl)-1-(2,5-difluorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)ethanone | Drug Info |
| Ftase --- FPTase | 1-[5,6-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N,N-dimethylpropan-1-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(2-pyridin-4-yl-acetyl)-piperazine-2-carboxylic acid cyclopropylmethyl-amide | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methoxy-benzoylamino)-benzenesulfonylamino]-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propan-1-ol | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(3-naphthalen-2-ylmethyl-3H-imidazol-4-yl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(cyclopropylcarbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-isobutyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-trifluoromethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-phenylpropanoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Lck --- VEGFR | 4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(4-(1-methylpiperidin-4-yloxy)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Nitro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-3-methyl-butyramide | Drug Info |
| Src --- VEGFR | Benzofuran-4-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | SID29217559 | Drug Info |
| MMP2 --- MMP9 | (R)-2-(Biphenyl-4-sulfonylamino)-N-hydroxy-3-(1H-indol-3-yl)-propionamide | Drug Info |
| VEGFR1 --- FGFR1 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3,5-Difluoro-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 2-(1,1-Dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide | Drug Info |
| VEGFR2 --- CD135 | (Z)-1-(3,4-Dimethoxyphenyl)-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]urea | Drug Info |
| Ftase --- FPTase | 3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-sulfonic acid dimethylamide | Drug Info |
| MMP2 --- MMP9 | 3-Cyclopentylmethyl-4-oxo-4-((4-phenylethynyl)phenyl)butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-({2'-methyl-5-[((E)-2-thiazol-5-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-butyric acid | Drug Info |
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