Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | Cyclic peptide analogue | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-cyclohexylacetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmethyl-acetamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Bis-trifluoromethyl-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | (R)-5-(4-chlorophenyl)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholinoethyl)thiophene-2-sulfonamide | Drug Info |
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3,5-diethoxybenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-methoxyphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-N-(3-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethoxy)phenoxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-chloro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 1-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)azepan-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-3-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-Furan-3-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylazo-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | (2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylmethyl-amide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| MMP3 --- MMP8 | [(R)-6-Amino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenylamide | Drug Info |
| MMP9 --- MMP3 | (R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic acid [(S)-1-(2-ethylamino-4-methyl-pentanoylaminocarbonyl)-3-methyl-butyl]-amide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| mTOR --- DNPK1 | 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 2-(N-Methylindol-3-ylmethylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-(4-morpholin-4-ylphenyl)urea | Drug Info |
| Ftase --- FPTase | 2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-methoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| Ftase --- FPTase | 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| NET --- SERT | 3-methoxy-5,6-dihydrobenzo[c]acridin-7-amine | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-tetradecanoic acid | Drug Info |
| NET --- SERT | 3-Piperidin-4-ylmethyl-1H-indole | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
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