Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP3 | (R)-3-(((S)-1-(2-carboxyethylamino)-3-cyclohexyl-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(3-quinolin-2-ylmethyl-3H-imidazol-4-yl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-5-(cyclohexyloxy)-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| MMP2 --- MMP3 | 2-[4-(3'-ethoxy-2-methyl-biphenyl-4-yl)-piperidine-1-sulfonyl]-N-hydroxy-2-methyl-propionamide | Drug Info |
| Ftase --- FPTase | Pseudopeptide derivative | Drug Info |
| VEGFR2 --- CSrc | 2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-benzo[d]imidazol-1-yl)pyrimidin-4-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(3'-trifluoromethyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | SID146411 | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-cyclopropyl-1H-pyrazole-5-carboxamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4-(tetrahydro-furan-2-yl)-phenyl]-hexanoic acid | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo[1,2-a]quinolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| VEGFR2 --- EGFR3 | CHEMBL1277620 | Drug Info |
| MMP-2 --- MMP-3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylpropylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1-methyl-1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}urea | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(2'-methoxy-biphenyl-4-ylmethyl)-succinamide | Drug Info |
| Ftase --- FPTase | 3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| VEGFR2 --- TEK | N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-methyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| VEGFR2 --- TEK | 3-(2-(3H-imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4'-chloro-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)biphenyl-4-sulfonamide | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(aminomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-isopropylthieno[2,3-d]pyrimidin-5-yl)phenyl)-3-m-tolylurea | Drug Info |
| MMP2 --- MMP9 | 2-(4-(2,4,6-Trioxo-5-(4-phenoxyphenyl)hexanhydropyrimidin-5-yl)-1,4-diazepane-1-carbonyl)benzylbenzoate | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazine-1-carboxylic acid tert-butyl ester | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(hydroxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-phenoxyphenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid aminomethyl-amide | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-(2-thiomorpholinoethyl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 1-(((2R,3R)-3-(2,4-dichlorobenzyloxy)-5-fluoro-2,3-dihydrobenzo[b]thiophen-2-yl)methyl)-1H-imidazole | Drug Info |
| VEGFR2 --- TEK | 9-cyclopentyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-phenyl-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-4-ylmethyl)-2-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| MMP2 --- MMP9 | (R)-2-{4-[2-(4-Cyclohexyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | Biphenyl-2-yl-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2-(pyridin-4-yl)ethyl)-N-m-tolylthiazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-2-nitro-benzoyl)-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | epicatechin-(4beta-8)-epicatechin-(4beta-6)-epicatechin | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-methoxy-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(4-{3-Methyl-5-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-ylamino]-benzyl}-piperazin-1-yl)-ethanone | Drug Info |
| MMP3 --- MMP8 | (R)-3-(4-Phenethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | Drug Info |
| Ftase --- FPTase | [(S)-4-[2-(3H-Imidazol-4-yl)-ethyl]-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-2-methoxy-benzoyl)-benzenesulfonamide | Drug Info |
| MMP3 --- MMP8 | 2-(5-Isoxazol-3-yl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 2-(2,3-Dihydroxy-benzoyl)-6-hydroxy-benzene-1,4-dicarbaldehyde | Drug Info |
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