Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP3 | (R)-2-[(S)-10-Amino-1-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-decylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-(piperidine-1-carbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thiophene-2-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2'-Methyl-5-pyrimidin-5-ylethynyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-2-(3-biphenyl-4-yl-propyl)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(1,1-diphenylbutylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,4-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP8 | cyclooctylcarbamoylphosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(methylamino)-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-pentanedioic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(dimethylamino)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-({2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-indane-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(isopropyl(methyl)amino)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-Ethyl 1-(3-hydroxyphenyl)-2-isobutyryl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(4-chlorobenzyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-cyanobenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | (5-(3-aminopropyl)-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)(azetidin-1-yl)methanone | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-butyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP9 | 3-hydroxy-1-((5-(4-methoxyphenyl)thiophen-2-ylsulfonyl)methyl)pyridin-2(1H)-one | Drug Info |
| Lck --- VEGFR | N-(4-chloro-2-methyl-3-(trifluoromethyl)phenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-2-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(p-tolyloxy)phenyl)phenylsulfonamido)propanamide | Drug Info |
| Src --- VEGFR | CHEMBL386996 | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-cyclopentanecarbonyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP9 | (R)-5-(4-chlorophenyl)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)thiophene-2-sulfonamide | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxymethyl-benzyl ester | Drug Info |
| MMP2 --- MMP9 | 4-(3-(N-hydroxyformamido)-4-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butyl)benzoic acid | Drug Info |
| VEGFR2 --- Beta PDGFR | (Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | Drug Info |
| Ftase --- FPTase | (S)-2-((R)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2,3-dimethylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Benzyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(4-methoxyphenyl)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxopiperidin-3-yl)benzenesulfonamide | Drug Info |
| VEGFR2 --- CDK1 | 1-(5-(3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N,N-dimethylmethanamine | Drug Info |
| Ftase --- FPTase | 10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodecatriene1-diphosphate (3-tbFPP) | Drug Info |
| MMP2 --- MMP9 | (ethylamino)carbonylphosphonic acid | Drug Info |
| VEGFR2 --- Ckit | N3-(2-aminopyrimidin-5-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(4-Methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 1-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methanesulfonyl-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP3 --- MMP8 | 2-(4-Butoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | SID174006531 | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(6-methyl-pyridin-3-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| MMP3 --- MMP8 | 2-(4-Acetylamino-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-6-(3-chloro-phenyl)-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-2-naphthalen-2-yl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-oxalamide | Drug Info |
| VEGFR2 --- CSrc | 4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info |
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