Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (R)-2-(phenylsulfonyl)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-(4'-chloro-2-methylbiphenyl-3-yl)-N-propylsulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | 1-(oct-7-enyl)-3-{12-[3-(pent-4-enyl)pyridinium-1-yl]dodecyl}-pyridinium chloride iodide | Drug Info |
| Erbeta --- ER | 3-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propionic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-Methyl-2-{3-[4-(3-phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenoxy}-propionic acid | Drug Info |
| HER2 --- CD221 | N-(3-(5-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-phenylacetamide | Drug Info |
| Erbeta --- ER | 8-bromo-3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(oxazol-4-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 2-Hydroxy-5-({2-[(3-{4-[1-(4-hydroxy-phenyl)-2-phenyl-butyl]-phenoxy}-propyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide | Drug Info |
| PPAR gamma --- PPAR delta | 4'-methoxy-3'-((4-phenoxybenzamido)methyl)biphenyl-3-carboxylic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-(piperazin-1-yl)phenoxy)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzoic acid methyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(2-((4-(trifluoromethyl)benzyl)(benzo[d]thiazol-2-yl)amino)ethoxy)phenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | trans-N-methyl-4-(9-((S)-tetrahydrofuran-3-yl)-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylamino)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-3-propyl-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[3-(2-phenyl-7-propylbenzo[b]furan-6-yloxy)propoxy]-indol-1-yl}ethanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-chlorophenyl)-4-bromothiazole-2-carboxamide | Drug Info |
| Erbeta --- ER | 6-(4-(methylsulfonyl)cyclohex-1-enyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)-5-fluorobenzoic acid | Drug Info |
| JNK1 --- JNK3 | 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid | Drug Info |
| Erbeta --- ER | 8-Ethynyl-6-(3-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(1,2,3,4-Tetrahydro-quinolin-7-yloxy)-ethoxy]-benzyl}-malonamic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-chlorophenyl)-1H-pyrrole-2-carboxamide | Drug Info |
| Erbeta --- ER | 3-Chloro-4-{(4S,5R)-5-[2-chloro-4-(2-dimethylamino-ethoxy)-phenyl]-4,5-dihydro-1H-imidazol-4-yl}-phenol | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclobutylamino)picolinamide | Drug Info |
| Erbeta --- ER | {6-Hydroxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}-phenyl-methanone | Drug Info |
| JNK1 --- JNK3 | 4-(8-(2-fluorophenylamino)-2-(4-methoxyphenylamino)-9H-purin-9-yl)cyclohexanol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(3-(2-(4-chlorophenyl)-4-methylthiazole-5-carboxamido)piperidin-1-yl)benzoic acid | Drug Info |
| Erbeta --- ER | SID49676928 | Drug Info |
| JNK1 --- JNK3 | 9-cyclopentyl-N8-(2-fluorophenyl)-N2-(4-methoxyphenyl)-9H-purine-2,8-diamine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(4-(2-hydroxyethyl)-1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| Erbeta --- ER | 4-[6-(Methyl-phenethyl-amino)-4-phenyl-pyridin-2-yl]-phenol | Drug Info |
| JNK1 --- JNK3 | CHEMBL203059 | Drug Info |
| PR --- mRNA of AR | 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid amide | Drug Info |
| MEP --- Cathepsin B | 2-(3-phenyl-1-(3-(trifluoromethyl)phenyl)allylidene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 2'-hydroxy-3-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| Erbeta --- ER | 1-[4-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-2-(naphthalene-1-sulfonylamino)-3-phenyl-propionamide | Drug Info |
| PR --- mRNA of AR | 1,2,3,6-tetrahydro-1-propyl-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| Erbeta --- ER | 4,7-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| MEP --- Cathepsin B | 2-((3,5-dichlorophenyl)(thiophen-2-yl)methylene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | 4'-Isoxazol-5-yl-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | rac 2-((4-cyano-3-(trifluoromethyl)phenyl)(2,2,2-trifluoroethyl)amino)-N,N-dimethylacetamide | Drug Info |
| Erbeta --- ER | 2-(4-(ethylsulfonyl)phenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)benzo[b]thiophen-6-ol | Drug Info |
| MEP --- Cathepsin B | (E)-methyl4-(2-((R,Z)-3-((4-chloro-2-(trifluoromethyl)phenylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate | Drug Info |
| PR --- mRNA of AR | 1,6,8,8,10-Pentamethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
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